Development Level

Tbio 54 | 11,445
Tchem 15 | 1,598
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
impaired pupillary reflex 2 | 26
increased circulating choleste... 2 | 66
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased circulating sodium l... 1 | 22
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased heart left ventricle... 1 | 4
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

ovarian cancer 42 | 8,520
Carcinoma 38 | 11,493
Cancer 33 | 2,499
osteosarcoma 33 | 7,950
lung cancer 28 | 4,740
glioblastoma 27 | 5,792
psoriasis 26 | 6,694
medulloblastoma, large-cell 23 | 6,241
Breast cancer 20 | 3,578
atypical teratoid / rhabdoid tumor 20 | 5,112
group 3 medulloblastoma 20 | 4,104
Kidney cancer 17 | 2,613
ependymoma 16 | 4,679
invasive ductal carcinoma 16 | 2,951
lung adenocarcinoma 16 | 2,716
breast carcinoma 14 | 1,638
Multiple myeloma 13 | 1,332
adult high grade glioma 12 | 3,801
diabetes mellitus 12 | 1,728
non-small cell lung cancer 12 | 2,890
subependymal giant cell astrocytoma 12 | 2,287
Downward slant of palpebral fissure 11 | 158
Orbital separation excessive 11 | 244
astrocytoma 11 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
Cleft Palate 10 | 271
Hypoplastic mandible condyle 10 | 275
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
astrocytic glioma 10 | 2,597
oligodendroglioma 10 | 2,850
primitive neuroectodermal tumor 10 | 3,035
Autosomal recessive predisposition 9 | 1,442
Cryptorchidism 9 | 296
Depressive disorder 9 | 409
Pick disease 9 | 1,894
Stomach Neoplasms 9 | 300
ductal carcinoma in situ 9 | 1,745
juvenile dermatomyositis 9 | 1,187
malignant mesothelioma 9 | 3,232
pancreatic cancer 9 | 2,398
Breast Neoplasms 8 | 445
Cleft Lip 8 | 141
Delayed bone age 8 | 136
Lung Neoplasms 8 | 232
Mammary Neoplasms 8 | 425
Muscle hypotonia 8 | 571
Seizures 8 | 596
Short stature 8 | 531
dermatomyositis 8 | 966
group 4 medulloblastoma 8 | 1,855
Astrocytoma, Pilocytic 7 | 3,081
Blepharoptosis 7 | 231
Byzanthine arch palate 7 | 194
Cognitive delay 7 | 608
Congenital Epicanthus 7 | 177
Dull intelligence 7 | 645
Epilepsy 7 | 792
Frontal bossing 7 | 157
Global developmental delay 7 | 608
Intellectual disability 7 | 1,016
Low intelligence 7 | 645
Low set ears 7 | 181
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Noonan syndrome 7 | 34
Pectus excavatum 7 | 100
Poor school performance 7 | 645
Rheumatoid arthritis 7 | 1,191
Schizophrenia 7 | 1,160
Wide spaced nipples 7 | 46
acute quadriplegic myopathy 7 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung carcinoma 7 | 2,843
pituitary cancer 7 | 1,972
primary pancreatic ductal adenocarcinoma 7 | 1,109
progressive supranuclear palsy 7 | 676
Concave bridge of nose 6 | 195
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Endometrial cancer 6 | 311
Generalized osteopenia 6 | 99
High forehead 6 | 102
Hypogonadotropic hypogonadism 6 | 89
Joint hyperflexibility 6 | 78
Melanocytic nevus 6 | 43
Neck webbing 6 | 35
Noncancerous mole 6 | 28
Osteopenia 6 | 99
Parkinson's disease 6 | 392
Squamous cell carcinoma 6 | 129
Strabismus 6 | 270
Tall forehead 6 | 102
Telecanthus 6 | 62
Triangular face 6 | 58
Ventricular Septal Defects 6 | 119
colon cancer 6 | 1,478
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989

Tissue

Endocrine System 71 | 18,159
Digestive Tract 70 | 17,369
Nervous System 70 | 16,725
Female tissues 69 | 17,400
Male tissues 69 | 17,142
Skin and soft tissues 69 | 17,230
Urinary Tract 69 | 16,678
Blood and immune system 68 | 16,909
Liver and Pancreas 68 | 16,750
Respiratory system 67 | 16,393
Cardiovascular System 64 | 15,192

Target Family

Non-IDG 44 | 12,091
Enzyme 21 | 4,145
Kinase 7 | 634

Reactome Pathway

Signaling by FGFR2 72 | 72
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Heterogeneous nuclear ribonucleoprotein M HNRNPM Tbio Non-IDG -1.64443 45.9 331
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Fibroblast growth factor-binding protein 2 FGFBP2 Tbio Non-IDG -0.80217 7.36 63
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328