Development Level

Tbio 22 | 11,445
Tchem 13 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to t... 5 | 278
abnormal embryo size 3 | 220
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
abnormal body wall morphology 1 | 9
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal skin coloration 1 | 25
cleft palate 1 | 8
decreased bone mineral content 1 | 151
decreased hematocrit 1 | 46
decreased mean corpuscular vol... 1 | 79
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased body temperature 1 | 9
increased circulating glucose ... 1 | 24
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
limb grasping 1 | 41
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 29 | 11,493
Cancer 26 | 2,499
ovarian cancer 25 | 8,520
osteosarcoma 24 | 7,950
lung cancer 21 | 4,740
atypical teratoid / rhabdoid tumor 20 | 5,112
glioblastoma 18 | 5,792
Breast cancer 16 | 3,578
psoriasis 16 | 6,694
ependymoma 15 | 4,679
medulloblastoma, large-cell 15 | 6,241
Kidney cancer 13 | 2,613
invasive ductal carcinoma 13 | 2,951
group 3 medulloblastoma 12 | 4,104
malignant mesothelioma 11 | 3,232
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Delayed bone age 9 | 136
Short stature 9 | 531
breast carcinoma 9 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
lung adenocarcinoma 9 | 2,716
non-small cell lung cancer 9 | 2,890
Astrocytoma, Pilocytic 8 | 3,081
Autosomal recessive predisposition 8 | 1,442
Byzanthine arch palate 8 | 194
Depressive disorder 8 | 409
Generalized osteopenia 8 | 99
Intellectual disability 8 | 1,016
Orbital separation excessive 8 | 244
Osteopenia 8 | 99
Rheumatoid arthritis 8 | 1,191
astrocytic glioma 8 | 2,597
primitive neuroectodermal tumor 8 | 3,035
Breast Neoplasms 7 | 445
Cryptorchidism 7 | 296
Frontal bossing 7 | 157
Hypoplastic mandible condyle 7 | 275
Mammary Neoplasms 7 | 425
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Pick disease 7 | 1,894
diabetes mellitus 7 | 1,728
group 4 medulloblastoma 7 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
juvenile dermatomyositis 7 | 1,187
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
pituitary cancer 7 | 1,972
subependymal giant cell astrocytoma 7 | 2,287
Acquired scoliosis 6 | 281
Carcinoma, Hepatocellular 6 | 228
Curvature of spine 6 | 282
Downward slant of palpebral fissure 6 | 158
Dull intelligence 6 | 645
Endometrial cancer 6 | 311
Hypogonadism, Isolated Hypogonadotropic 6 | 71
Hypogonadotropic hypogonadism 6 | 89
Joint hyperflexibility 6 | 78
Liver carcinoma 6 | 240
Low intelligence 6 | 645
Lung Neoplasms 6 | 232
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Seizures 6 | 596
Strabismus 6 | 270
Wide spaced nipples 6 | 46
adult high grade glioma 6 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Abnormally small eyeball 5 | 97
Bipolar Disorder 5 | 666
Blepharoptosis 5 | 231
Cognitive delay 5 | 608
Concave bridge of nose 5 | 195
Congenital Epicanthus 5 | 177
Decreased size of eyeball 5 | 97
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Epilepsy 5 | 792
Global developmental delay 5 | 608
High forehead 5 | 102
Increased fracture rate 5 | 53
Isolated cases 5 | 72
Low set ears 5 | 181
Mental and motor retardation 5 | 608
Multiple myeloma 5 | 1,332
Osteoporosis 5 | 363
Parkinson's disease 5 | 392
Schizophrenia 5 | 1,160
Stomach Neoplasms 5 | 300
Tall forehead 5 | 102
Telecanthus 5 | 62
Varying degree of multiple fractures 5 | 53
astrocytoma 5 | 1,146
cystic fibrosis 5 | 1,696
interstitial cystitis 5 | 2,312
nasopharyngeal carcinoma 5 | 1,058
pancreatic carcinoma 5 | 562
ulcerative colitis 5 | 1,819

Tissue

Endocrine System 37 | 18,159
Digestive Tract 36 | 17,369
Nervous System 36 | 16,725
Blood and immune system 35 | 16,909
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Male tissues 35 | 17,142
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678
Respiratory system 34 | 16,393
Cardiovascular System 32 | 15,192

Target Family

Non-IDG 25 | 12,091
Transcription Factor 5 | 1,400
Enzyme 4 | 4,145
Kinase 3 | 634
Epigenetic 1 | 242

Reactome Pathway

Signaling by FGFR1 in disease 38 | 38
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Transcription intermediary factor 1-alpha TRIM24 Tchem Epigenetic -2.15509 143.0 372
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Breakpoint cluster region protein BCR Tclin Non-IDG -2.99605 934.2 437
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.07061 109.8 192
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.13063 1294.7 1785
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Homeobox protein cut-like 1 CUX1 Tbio Non-IDG -2.43505 487.9 295