Development Level

Tbio 30 | 10,625
Tchem 16 | 1,890
Tclin 3 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 633
embryonic lethality prior to t... 4 | 187
abnormal embryo size 3 | 112
decreased kidney weight 2 | 7
abnormal behavior 1 | 226
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal motor learning 1 | 4
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
abnormal tail morphology 1 | 17
cataract 1 | 26
cleft palate 1 | 6
corneal opacity 1 | 25
decreased bone mineral content 1 | 157
decreased grip strength 1 | 123
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
immune system phenotype 1 | 17
impaired pupillary reflex 1 | 14
increased circulating HDL chol... 1 | 63
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
narrow eye opening 1 | 15
no spontaneous movement 1 | 1
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 31 | 8,491
Cancer 29 | 2,346
osteosarcoma 25 | 7,933
lung cancer 22 | 4,473
glioblastoma 21 | 5,572
medulloblastoma, large-cell 21 | 6,234
psoriasis 17 | 6,685
Breast cancer 15 | 3,098
atypical teratoid / rhabdoid tumor 15 | 4,369
Carcinoma 13 | 2,147
lung adenocarcinoma 12 | 2,714
astrocytoma 11 | 1,493
ependymoma 11 | 2,514
invasive ductal carcinoma 11 | 2,950
astrocytic glioma 10 | 2,241
pediatric high grade glioma 10 | 2,712
Lung Neoplasms 9 | 171
Noonan Syndrome 9 | 33
Pick disease 9 | 1,893
non-small cell lung cancer 9 | 2,798
oligodendroglioma 9 | 2,849
Mammary Neoplasms 8 | 410
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
juvenile dermatomyositis 8 | 1,189
lung carcinoma 8 | 2,844
pancreatic cancer 8 | 2,300
pituitary cancer 8 | 1,972
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 2,087
Cleft Lip 7 | 91
Cleft palate 7 | 125
breast carcinoma 7 | 1,614
cystic fibrosis 7 | 1,670
ductal carcinoma in situ 7 | 1,745
group 3 medulloblastoma 7 | 2,254
interstitial cystitis 7 | 2,299
malignant mesothelioma 7 | 3,163
tuberculosis 7 | 1,563
Cardiofaciocutaneous syndrome 6 | 15
Costello Syndrome 6 | 18
Multiple myeloma 6 | 1,327
Parkinson's disease 6 | 364
Rheumatoid Arthritis 6 | 1,170
Squamous cell carcinoma 6 | 96
Stomach Neoplasms 6 | 282
diabetes mellitus 6 | 1,663
group 4 medulloblastoma 6 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
medulloblastoma 6 | 1,524
non-small cell lung carcinoma 6 | 413
pilocytic astrocytoma 6 | 3,086
Adenoma 5 | 165
Craniosynostosis 5 | 47
Cryptorchidism 5 | 67
Immune system cancer 5 | 38
Intellectual disability 5 | 573
Kallmann Syndrome 5 | 33
Kidney cancer 5 | 121
Klinefelter's syndrome 5 | 59
Liver carcinoma 5 | 217
Papillary thyroid carcinoma 5 | 37
Vascular disease 5 | 281
primary pancreatic ductal adenocarcinoma 5 | 1,271
primitive neuroectodermal tumor 5 | 3,031
progressive supranuclear palsy 5 | 674
Achondroplasia 4 | 20
Alzheimer's disease 4 | 644
Arthritis 4 | 248
Carcinoma of colon 4 | 32
Cardio-facio-cutaneous syndrome 4 | 6
Colorectal Neoplasms 4 | 217
Connective tissue cancer 4 | 9
Costello syndrome (disorder) 4 | 7
Craniofacial Abnormalities 4 | 147
Down syndrome 4 | 548
Endometrial cancer 4 | 32
Heart disease 4 | 279
Hypogonadotropic hypogonadism 4 | 20
Juvenile Myelomonocytic Leukemia 4 | 21
Kidney disease 4 | 397
LADD syndrome 4 | 9
LEOPARD Syndrome 4 | 20
Lymphoid leukemia 4 | 69
Neoplasm Invasiveness 4 | 127
Neuroblastoma 4 | 78
Nevus, Epidermal 4 | 5
Prostatic Neoplasms 4 | 471
Renal Cell Carcinoma 4 | 199
Thyroid cancer 4 | 25
colon cancer 4 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
ovarian neoplasm 4 | 97
tuberculosis and treatment for 6 months 4 | 686
Myocardial Ischemia 3 | 169
Polycystic Ovary Syndrome 3 | 334
Synostosis 3 | 18
adrenocortical carcinoma 3 | 1,427
adult high grade glioma 3 | 2,148
nasopharyngeal carcinoma 3 | 1,056
pancreatic carcinoma 3 | 567

Tissue

Endocrine System 50 | 18,511
Female tissues 50 | 18,646
Nervous System 50 | 18,560
Skin and soft tissues 50 | 18,114
Blood and immune system 49 | 17,994
Cardiovascular System 49 | 17,957
Digestive Tract 49 | 18,472
Liver and Pancreas 49 | 18,135
Male tissues 49 | 17,968
Urinary Tract 49 | 18,443
Respiratory system 45 | 17,483

Target Family

Non-IDG 32 | 11,969
Enzyme 10 | 4,146
Kinase 8 | 634

Reactome Pathway

Signaling by FGFR1 50 | 50
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Leucine-rich repeat transmembrane protein FLRT2 FLRT2 Tbio Non-IDG -1.05975 10.9 48
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.89335 9.09 133
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
GTPase NRas NRAS Tchem Enzyme -2.98048 880.4 265
Protein sprouty homolog 2 SPRY2 Tbio Non-IDG -1.86730 81.5 178
Leucine-rich repeat transmembrane protein FLRT3 FLRT3 Tbio Non-IDG -1.26677 19.4 49
Leucine-rich repeat transmembrane protein FLRT1 FLRT1 Tdark Non-IDG -0.47366 1.66 80
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform PPP2R1A Tbio Enzyme -1.40388 25.3 259