Development Level

Tbio 30 | 10,625
Tchem 16 | 1,890
Tclin 3 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to t... 4 | 187
abnormal embryo size 3 | 112
decreased kidney weight 2 | 7
abnormal behavior 1 | 226
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal motor learning 1 | 4
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
abnormal tail morphology 1 | 17
cataract 1 | 26
cleft palate 1 | 6
corneal opacity 1 | 25
decreased bone mineral content 1 | 157
decreased grip strength 1 | 123
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
immune system phenotype 1 | 17
impaired pupillary reflex 1 | 14
increased circulating HDL chol... 1 | 63
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
narrow eye opening 1 | 15
no spontaneous movement 1 | 1
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 30 | 8,484
Cancer 29 | 2,346
osteosarcoma 25 | 7,933
lung cancer 22 | 4,466
glioblastoma 21 | 5,572
medulloblastoma, large-cell 21 | 6,234
psoriasis 17 | 6,685
Breast cancer 15 | 3,094
atypical teratoid / rhabdoid tumor 15 | 4,369
Carcinoma 13 | 2,147
lung adenocarcinoma 12 | 2,713
astrocytoma 11 | 1,493
ependymoma 11 | 2,514
invasive ductal carcinoma 11 | 2,950
astrocytic glioma 10 | 2,241
pediatric high grade glioma 10 | 2,712
Lung Neoplasms 9 | 171
Noonan Syndrome 9 | 33
Pick disease 9 | 1,893
non-small cell lung cancer 9 | 2,798
oligodendroglioma 9 | 2,849
Mammary Neoplasms 8 | 410
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
juvenile dermatomyositis 8 | 1,189
lung carcinoma 8 | 2,844
pancreatic cancer 8 | 2,300
pituitary cancer 8 | 1,972
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 2,087
Cleft Lip 7 | 91
Cleft palate 7 | 125
breast carcinoma 7 | 1,614
cystic fibrosis 7 | 1,665
ductal carcinoma in situ 7 | 1,745
group 3 medulloblastoma 7 | 2,254
interstitial cystitis 7 | 2,299
malignant mesothelioma 7 | 3,162
tuberculosis 7 | 1,557
Cardiofaciocutaneous syndrome 6 | 15
Multiple myeloma 6 | 1,327
Parkinson's disease 6 | 364
Rheumatoid Arthritis 6 | 1,160
Squamous cell carcinoma 6 | 94
Stomach Neoplasms 6 | 282
diabetes mellitus 6 | 1,663
group 4 medulloblastoma 6 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
medulloblastoma 6 | 1,524
non-small cell lung carcinoma 6 | 413
pilocytic astrocytoma 6 | 3,086
Adenoma 5 | 165
Craniosynostosis 5 | 47
Cryptorchidism 5 | 67
Immune system cancer 5 | 38
Intellectual disability 5 | 573
Kallmann Syndrome 5 | 33
Kidney cancer 5 | 118
Klinefelter's syndrome 5 | 59
Liver carcinoma 5 | 217
Papillary thyroid carcinoma 5 | 37
Vascular disease 5 | 281
primary pancreatic ductal adenocarcinoma 5 | 1,271
primitive neuroectodermal tumor 5 | 3,031
progressive supranuclear palsy 5 | 674
Achondroplasia 4 | 20
Alzheimer's disease 4 | 644
Arthritis 4 | 248
Cardio-facio-cutaneous syndrome 4 | 6
Colorectal Neoplasms 4 | 217
Connective tissue cancer 4 | 9
Costello syndrome 4 | 16
Costello syndrome (disorder) 4 | 7
Craniofacial Abnormalities 4 | 147
Down syndrome 4 | 548
Endometrial cancer 4 | 25
Heart disease 4 | 279
Juvenile Myelomonocytic Leukemia 4 | 21
Kidney disease 4 | 396
LADD syndrome 4 | 9
LEOPARD Syndrome 4 | 20
Lymphoid leukemia 4 | 69
Neoplasm Invasiveness 4 | 127
Neuroblastoma 4 | 78
Prostatic Neoplasms 4 | 471
Renal Cell Carcinoma 4 | 199
Thyroid cancer 4 | 25
colon cancer 4 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,988
ovarian neoplasm 4 | 97
tuberculosis and treatment for 6 months 4 | 686
Myocardial Ischemia 3 | 169
Polycystic Ovary Syndrome 3 | 332
Synostosis 3 | 18
acute myeloid leukemia 3 | 780
adrenocortical carcinoma 3 | 1,427
adult high grade glioma 3 | 2,148
dermatomyositis 3 | 933
nasopharyngeal carcinoma 3 | 1,056
pancreatic carcinoma 3 | 567
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795

Tissue

Endocrine System 50 | 18,512
Female tissues 50 | 18,647
Nervous System 50 | 18,561
Skin and soft tissues 50 | 18,115
Blood and immune system 49 | 17,995
Cardiovascular System 49 | 17,958
Digestive Tract 49 | 18,473
Liver and Pancreas 49 | 18,136
Male tissues 49 | 17,969
Urinary Tract 49 | 18,444
Respiratory system 45 | 17,484

Target Family

Non-IDG 32 | 11,971
Enzyme 10 | 4,146
Kinase 8 | 634

Reactome Pathway

Signaling by FGFR1 50 | 50
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.51373 345.1 271
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Anosmin-1 ANOS1 Tbio Non-IDG -2.61285 410.8 140
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.07424 1194.2 1600
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -3.97848 10115.4 658
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424