Development Level

Tbio 44 | 11,445
Tchem 13 | 1,598
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to t... 6 | 278
abnormal embryo size 4 | 220
abnormal bone structure 3 | 187
abnormal retinal vasculature m... 3 | 27
cataract 3 | 92
abnormal lens morphology 2 | 81
abnormal retinal blood vessel ... 2 | 26
decreased bone mineral content 2 | 151
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
impaired pupillary reflex 2 | 26
impaired righting response 2 | 26
increased circulating choleste... 2 | 66
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal limb bud morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased circulating sodium l... 1 | 22
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
fused cornea and lens 1 | 5
hemorrhage 1 | 23
increased body length 1 | 32
increased body temperature 1 | 9
increased circulating HDL chol... 1 | 80
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 37 | 11,493
ovarian cancer 36 | 8,520
osteosarcoma 32 | 7,950
Cancer 31 | 2,499
lung cancer 31 | 4,740
atypical teratoid / rhabdoid tumor 23 | 5,112
psoriasis 23 | 6,694
Breast cancer 22 | 3,578
glioblastoma 21 | 5,792
Kidney cancer 18 | 2,613
ependymoma 18 | 4,679
medulloblastoma, large-cell 18 | 6,241
group 3 medulloblastoma 17 | 4,104
invasive ductal carcinoma 17 | 2,951
malignant mesothelioma 17 | 3,232
non-small cell lung cancer 17 | 2,890
breast carcinoma 15 | 1,638
lung adenocarcinoma 14 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
ductal carcinoma in situ 12 | 1,745
Autosomal recessive predisposition 11 | 1,442
Orbital separation excessive 11 | 244
Short stature 11 | 531
Astrocytoma, Pilocytic 10 | 3,081
Breast Neoplasms 10 | 445
Byzanthine arch palate 10 | 194
Cleft Palate 10 | 271
Downward slant of palpebral fissure 10 | 158
Intellectual disability 10 | 1,016
Mammary Neoplasms 10 | 425
Multiple myeloma 10 | 1,332
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
oligodendroglioma 10 | 2,850
Cleft Lip 9 | 141
Cryptorchidism 9 | 296
Delayed bone age 9 | 136
Depressive disorder 9 | 409
Frontal bossing 9 | 157
Generalized osteopenia 9 | 99
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Osteopenia 9 | 99
Rheumatoid arthritis 9 | 1,191
adult high grade glioma 9 | 3,801
pancreatic cancer 9 | 2,398
primitive neuroectodermal tumor 9 | 3,035
subependymal giant cell astrocytoma 9 | 2,287
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Seizures 8 | 596
Strabismus 8 | 270
Telecanthus 8 | 62
astrocytic glioma 8 | 2,597
astrocytoma 8 | 1,146
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
pituitary cancer 8 | 1,972
Achondroplasia 7 | 21
Acquired scoliosis 7 | 281
Blepharoptosis 7 | 231
Carcinoma, Hepatocellular 7 | 228
Cognitive delay 7 | 608
Concave bridge of nose 7 | 195
Curvature of spine 7 | 282
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Endometrial cancer 7 | 311
Epilepsy 7 | 792
Global developmental delay 7 | 608
High forehead 7 | 102
Joint hyperflexibility 7 | 78
Liver carcinoma 7 | 240
Lung Neoplasms 7 | 232
Mental and motor retardation 7 | 608
Pick disease 7 | 1,894
Stomach Neoplasms 7 | 300
Tall forehead 7 | 102
interstitial cystitis 7 | 2,312
juvenile dermatomyositis 7 | 1,187
lung carcinoma 7 | 2,843
Bipolar Disorder 6 | 666
Broad forehead 6 | 59
Craniosynostosis 6 | 74
Exophthalmos 6 | 112
Increased head circumference 6 | 147
Isolated cases 6 | 72
Liver Cirrhosis 6 | 181
Prominent eyes 6 | 96
Prominent globes 6 | 96
Protruding eyes 6 | 96
Schizophrenia 6 | 1,160
acute quadriplegic myopathy 6 | 1,158
pancreatic carcinoma 6 | 562
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
ulcerative colitis 6 | 1,819

Tissue

Endocrine System 61 | 18,159
Digestive Tract 60 | 17,369
Nervous System 60 | 16,725
Female tissues 59 | 17,400
Male tissues 59 | 17,142
Skin and soft tissues 59 | 17,230
Urinary Tract 59 | 16,678
Blood and immune system 58 | 16,909
Liver and Pancreas 58 | 16,750
Respiratory system 57 | 16,393
Cardiovascular System 55 | 15,192

Target Family

Non-IDG 35 | 12,091
Enzyme 16 | 4,145
Kinase 6 | 634
Transcription Factor 5 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Signaling by FGFR in disease 63 | 63
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
Transcription intermediary factor 1-alpha TRIM24 Tchem Epigenetic -2.15509 143.0 372
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.75464 57.5 162