Development Level

Tbio 63 | 11,445
Tchem 15 | 1,598
Tclin 7 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to t... 5 | 278
abnormal embryo size 3 | 220
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
embryonic lethality prior to o... 2 | 239
impaired pupillary reflex 2 | 26
increased circulating choleste... 2 | 66
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased circulating sodium l... 1 | 22
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased heart left ventricle... 1 | 4
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Carcinoma 50 | 11,493
ovarian cancer 49 | 8,520
osteosarcoma 39 | 7,950
Cancer 38 | 2,499
lung cancer 34 | 4,740
glioblastoma 33 | 5,792
psoriasis 29 | 6,694
medulloblastoma, large-cell 28 | 6,241
Breast cancer 27 | 3,578
atypical teratoid / rhabdoid tumor 24 | 5,112
ependymoma 22 | 4,679
group 3 medulloblastoma 22 | 4,104
Kidney cancer 21 | 2,613
invasive ductal carcinoma 21 | 2,951
lung adenocarcinoma 20 | 2,716
non-small cell lung cancer 19 | 2,890
breast carcinoma 18 | 1,638
adult high grade glioma 16 | 3,801
astrocytic glioma 16 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
Multiple myeloma 15 | 1,332
Orbital separation excessive 15 | 244
diabetes mellitus 15 | 1,728
malignant mesothelioma 15 | 3,232
oligodendroglioma 15 | 2,850
Downward slant of palpebral fissure 14 | 158
ductal carcinoma in situ 14 | 1,745
pancreatic cancer 14 | 2,398
Cleft Palate 13 | 271
Cryptorchidism 13 | 296
Hypoplastic mandible condyle 13 | 275
Mandibular hypoplasia 13 | 275
Micrognathism 13 | 275
astrocytoma 13 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
subependymal giant cell astrocytoma 13 | 2,287
Autosomal recessive predisposition 12 | 1,442
Pick disease 12 | 1,894
Seizures 12 | 596
Short stature 12 | 531
Astrocytoma, Pilocytic 11 | 3,081
Blepharoptosis 11 | 231
Cleft Lip 11 | 141
Cognitive delay 11 | 608
Delayed bone age 11 | 136
Epilepsy 11 | 792
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
interstitial cystitis 11 | 2,312
Byzanthine arch palate 10 | 194
Depressive disorder 10 | 409
Dull intelligence 10 | 645
Frontal bossing 10 | 157
High forehead 10 | 102
Intellectual disability 10 | 1,016
Low intelligence 10 | 645
Lung Neoplasms 10 | 232
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Muscle hypotonia 10 | 571
Poor school performance 10 | 645
Stomach Neoplasms 10 | 300
Strabismus 10 | 270
Tall forehead 10 | 102
group 4 medulloblastoma 10 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
juvenile dermatomyositis 10 | 1,187
pituitary cancer 10 | 1,972
primitive neuroectodermal tumor 10 | 3,035
Breast Neoplasms 9 | 445
Concave bridge of nose 9 | 195
Congenital Epicanthus 9 | 177
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Exophthalmos 9 | 112
Hypogonadism, Isolated Hypogonadotropic 9 | 71
Hypogonadotropic hypogonadism 9 | 89
Low set ears 9 | 181
Mammary Neoplasms 9 | 425
Noonan syndrome 9 | 34
Pectus excavatum 9 | 100
Prominent eyes 9 | 96
Prominent globes 9 | 96
Protruding eyes 9 | 96
Wide spaced nipples 9 | 46
lung carcinoma 9 | 2,843
ulcerative colitis 9 | 1,819
Acquired scoliosis 8 | 281
Curvature of spine 8 | 282
Joint hyperflexibility 8 | 78
Prostatic Neoplasms 8 | 495
Rheumatoid arthritis 8 | 1,191
Schizophrenia 8 | 1,160
Ventricular Septal Defects 8 | 119
colon cancer 8 | 1,478
cystic fibrosis 8 | 1,696
dermatomyositis 8 | 966
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primary pancreatic ductal adenocarcinoma 8 | 1,109
tuberculosis 8 | 2,010

Tissue

Endocrine System 85 | 18,159
Digestive Tract 84 | 17,369
Nervous System 84 | 16,725
Female tissues 83 | 17,400
Male tissues 83 | 17,142
Skin and soft tissues 83 | 17,230
Urinary Tract 83 | 16,678
Blood and immune system 82 | 16,909
Liver and Pancreas 82 | 16,750
Respiratory system 80 | 16,393
Cardiovascular System 78 | 15,192

Target Family

Non-IDG 51 | 12,091
Enzyme 24 | 4,145
Kinase 11 | 634

Reactome Pathway

Signaling by FGFR 86 | 86
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Leucine-rich repeat transmembrane protein FLRT2 FLRT2 Tbio Non-IDG -1.09240 12.6 50
Heterogeneous nuclear ribonucleoprotein M HNRNPM Tbio Non-IDG -1.64443 45.9 331
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Fibroblast growth factor-binding protein 2 FGFBP2 Tbio Non-IDG -0.80217 7.36 63
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574