Development Level

Tbio 26 | 11,445
Tchem 15 | 1,598
Tclin 8 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 2 | 220
abnormal pericardium morpholog... 2 | 26
edema 2 | 59
prenatal lethality 2 | 28
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal eyelid fusion 1 | 3
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 4
abnormal skin appearance 1 | 3
abnormal skin coloration 1 | 25
abnormal snout morphology 1 | 23
abnormal urinary bladder morph... 1 | 11
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased leukocyte cell numbe... 1 | 73
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
thrombocytosis 1 | 27

Disease

Carcinoma 37 | 11,493
Cancer 31 | 2,499
ovarian cancer 31 | 8,520
osteosarcoma 30 | 7,950
lung cancer 25 | 4,740
glioblastoma 23 | 5,792
medulloblastoma, large-cell 21 | 6,241
psoriasis 21 | 6,694
Breast cancer 20 | 3,578
atypical teratoid / rhabdoid tumor 19 | 5,112
pancreatic cancer 17 | 2,398
ependymoma 16 | 4,679
Kidney cancer 15 | 2,613
interstitial cystitis 14 | 2,312
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
lung adenocarcinoma 13 | 2,716
invasive ductal carcinoma 12 | 2,951
Autosomal recessive predisposition 11 | 1,442
Schizophrenia 11 | 1,160
group 3 medulloblastoma 11 | 4,104
ulcerative colitis 11 | 1,819
Astrocytoma, Pilocytic 10 | 3,081
Rheumatoid arthritis 10 | 1,191
Stomach Neoplasms 10 | 300
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
juvenile dermatomyositis 10 | 1,187
oligodendroglioma 10 | 2,850
primary pancreatic ductal adenocarcinoma 10 | 1,109
Seizures 9 | 596
group 4 medulloblastoma 9 | 1,855
lung carcinoma 9 | 2,843
primitive neuroectodermal tumor 9 | 3,035
spina bifida 9 | 1,074
Bipolar Disorder 8 | 666
Epilepsy 8 | 792
Hypoplastic mandible condyle 8 | 275
Lung Neoplasms 8 | 232
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
adult high grade glioma 8 | 3,801
astrocytoma 8 | 1,146
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
nasopharyngeal carcinoma 8 | 1,058
pancreatic carcinoma 8 | 562
pituitary cancer 8 | 1,972
Multiple myeloma 7 | 1,332
Neoplasm Metastasis 7 | 168
astrocytic glioma 7 | 2,597
cystic fibrosis 7 | 1,696
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 2,010
Adenocarcinoma 6 | 122
Adenoma 6 | 167
Colorectal Neoplasms 6 | 243
Disease Progression 6 | 136
Heart disease 6 | 306
Liver cancer 6 | 604
Melanoma 6 | 711
Neoplasm Invasiveness 6 | 161
Noonan syndrome 6 | 34
Orbital separation excessive 6 | 244
Prostatic Neoplasms 6 | 495
Ventricular Septal Defects 6 | 119
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
pediatric high grade glioma 6 | 1,064
Adenocarcinoma of lung 5 | 142
Bladder Neoplasm 5 | 112
Byzanthine arch palate 5 | 194
Carcinoma, Hepatocellular 5 | 228
Concave bridge of nose 5 | 195
Delayed bone age 5 | 136
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Diarrhea 5 | 253
Endometrial cancer 5 | 311
Endometriosis 5 | 540
Failure to gain weight 5 | 365
Frontal bossing 5 | 157
Hepatomegaly 5 | 285
Joint hyperflexibility 5 | 78
Liver Cirrhosis, Experimental 5 | 769
Liver carcinoma 5 | 240
Major Depressive Disorder 5 | 301
Pediatric failure to thrive 5 | 365
Telecanthus 5 | 62
Unipolar Depression 5 | 250
Urinary Bladder Neoplasms 5 | 114
acute myeloid leukemia 5 | 783
fibroadenoma 5 | 559
hepatocellular carcinoma 5 | 547
mucosa-associated lymphoid tissue lymphoma 5 | 484
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
progressive supranuclear palsy 5 | 676

Tissue

Blood and immune system 49 | 16,909
Digestive Tract 49 | 17,369
Endocrine System 49 | 18,159
Female tissues 49 | 17,400
Liver and Pancreas 49 | 16,750
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Respiratory system 49 | 16,393
Skin and soft tissues 49 | 17,230
Urinary Tract 49 | 16,678
Cardiovascular System 48 | 15,192

Target Family

Non-IDG 23 | 12,091
Kinase 16 | 634
Enzyme 10 | 4,145

Reactome Pathway

Signaling by ERBB2 49 | 49
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Tyrosine-protein phosphatase non-receptor type 18 PTPN18 Tbio Enzyme -0.77241 5.46 77
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181