Development Level

Tbio 9 | 11,651
Tchem 7 | 1,388
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal snout morphology 1 | 23
decreased leukocyte cell numbe... 1 | 73
increased circulating glucose ... 1 | 24
increased grip strength 1 | 41
male infertility 1 | 123
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Carcinoma 14 | 11,493
ovarian cancer 14 | 8,520
Cancer 13 | 2,499
lung cancer 13 | 4,740
osteosarcoma 11 | 7,950
Breast cancer 9 | 3,578
glioblastoma 9 | 5,792
Hypoplastic mandible condyle 7 | 275
Kidney cancer 7 | 2,613
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
atypical teratoid / rhabdoid tumor 7 | 5,112
juvenile dermatomyositis 7 | 1,187
medulloblastoma, large-cell 7 | 6,241
pancreatic cancer 7 | 2,398
psoriasis 7 | 6,694
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
Adenocarcinoma of lung 5 | 142
Adenocarcinoma of lung (disorder) 5 | 60
Autosomal recessive predisposition 5 | 1,442
Byzanthine arch palate 5 | 194
Carcinoma, Hepatocellular 5 | 228
Delayed bone age 5 | 136
Downward slant of palpebral fissure 5 | 158
Epilepsy 5 | 792
Frontal bossing 5 | 157
Joint hyperflexibility 5 | 78
Liver carcinoma 5 | 240
Muscle hypotonia 5 | 571
Neoplasm Metastasis 5 | 168
Noonan syndrome 5 | 34
Orbital separation excessive 5 | 244
Seizures 5 | 596
Stomach Neoplasms 5 | 300
Upper respiratory tract disease 5 | 15
lung adenocarcinoma 5 | 2,716
pancreatic carcinoma 5 | 562
primary pancreatic ductal adenocarcinoma 5 | 1,109
Abnormally small eyeball 4 | 97
Acquired scoliosis 4 | 281
Adenocarcinoma 4 | 122
Adenoma 4 | 167
Asymmetric growth 4 | 5
Basal cell carcinoma 4 | 54
Big calvaria 4 | 147
Blepharoptosis 4 | 231
Carcinoma, Squamous Cell 4 | 110
Cardiac Arrhythmia 4 | 103
Cardiac conduction abnormalities 4 | 78
Cerebellar hypoplasia and atrophy 4 | 41
Colorectal Neoplasms 4 | 243
Concave bridge of nose 4 | 195
Conduction disorder of the heart 4 | 79
Congenital Epicanthus 4 | 177
Curvature of spine 4 | 282
DOID:2627 4 | 94
Decreased size of eyeball 4 | 97
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Diarrhea 4 | 253
Disease Progression 4 | 136
EKG abnormalities 4 | 78
Electrocardiogram abnormal 4 | 81
Electrocardiogram change 4 | 78
Endometrial cancer 4 | 311
Failure to gain weight 4 | 365
Fetal overgrowth 4 | 16
Full lower lip 4 | 64
Generalized overgrowth 4 | 16
Hemangioma, Cavernous 4 | 20
High forehead 4 | 102
Hyperplasia of cheeks 4 | 50
Hypertrophy of cheeks 4 | 50
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Isolated cases 4 | 72
Lung Neoplasms 4 | 232
Melanocytic nevus 4 | 43
Melanoma 4 | 711
Multiple myeloma 4 | 1,332
Noncancerous mole 4 | 28
Overgrowth 4 | 16
Pectus excavatum 4 | 100
Pediatric failure to thrive 4 | 365
Prominent lower lip 4 | 64
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Sebaceous adenoma 4 | 26
Squamous cell carcinoma 4 | 129
Strabismus 4 | 270
Tall forehead 4 | 102
Telecanthus 4 | 62
Triangular face 4 | 58
Ventricular Septal Defects 4 | 119
astrocytic glioma 4 | 2,597
breast carcinoma 4 | 1,638
group 3 medulloblastoma 4 | 4,104
invasive ductal carcinoma 4 | 2,951

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 11 | 12,091
Enzyme 4 | 4,145
Kinase 3 | 634

Reactome Pathway

Signaling by EGFR in Cancer 18 | 18
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 PLCG1 Tchem Enzyme -2.90339 786.2 846
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
GTPase KRas KRAS Tbio Enzyme -3.80300 6069.9 574
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328