Development Level

Tbio 9 | 10,625
Tchem 9 | 1,890
Tclin 1 | 602

IMPC Term

abnormal snout morphology 1 | 18
decreased caudal vertebrae num... 1 | 49
decreased leukocyte cell numbe... 1 | 54
increased grip strength 1 | 83
male infertility 1 | 62
preweaning lethality, incomple... 1 | 260

Disease

Cancer 14 | 2,346
ovarian cancer 14 | 8,484
lung cancer 12 | 4,466
osteosarcoma 12 | 7,933
Carcinoma 10 | 2,147
glioblastoma 9 | 5,572
Breast cancer 8 | 3,094
medulloblastoma, large-cell 8 | 6,234
atypical teratoid / rhabdoid tumor 7 | 4,369
juvenile dermatomyositis 7 | 1,189
pancreatic cancer 7 | 2,300
psoriasis 7 | 6,685
Mammary Neoplasms 6 | 410
Kidney cancer 5 | 118
Liver carcinoma 5 | 217
Noonan Syndrome 5 | 33
Rheumatoid Arthritis 5 | 1,160
lung adenocarcinoma 5 | 2,713
pancreatic carcinoma 5 | 567
primary pancreatic ductal adenocarcinoma 5 | 1,271
Adenocarcinoma 4 | 115
Adenoma 4 | 165
Colorectal Neoplasms 4 | 217
Lung Neoplasms 4 | 171
Multiple myeloma 4 | 1,327
Neoplasm Metastasis 4 | 138
Pick disease 4 | 1,893
Squamous cell carcinoma 4 | 94
Stomach Neoplasms 4 | 282
astrocytic glioma 4 | 2,241
invasive ductal carcinoma 4 | 2,950
non-small cell lung carcinoma 4 | 413
pediatric high grade glioma 4 | 2,712
ulcerative colitis 4 | 2,087
Adenocarcinoma in situ 3 | 15
Adenocarcinoma of lung (disorder) 3 | 48
Animal Mammary Neoplasms 3 | 136
Autistic Disorder 3 | 320
Bladder Neoplasm 3 | 109
Cardiofaciocutaneous syndrome 3 | 15
Connective tissue cancer 3 | 9
Diarrhea 3 | 155
Disease Progression 3 | 125
Endometrial cancer 3 | 25
Exanthem 3 | 39
Hemangiosarcoma 3 | 18
Immune system cancer 3 | 38
Juvenile Myelomonocytic Leukemia 3 | 21
Mammary Neoplasms, Experimental 3 | 150
Mouth Neoplasms 3 | 42
NEVUS, EPIDERMAL (disorder) 3 | 4
Neoplasm Invasiveness 3 | 127
Neoplasms, Experimental 3 | 33
Neuroblastoma 3 | 78
Neutropenia 3 | 78
Papillary thyroid carcinoma 3 | 37
Paronychia 3 | 7
Penile Neoplasms 3 | 4
Prostatic Neoplasms 3 | 471
Thyroid cancer 3 | 25
astrocytoma 3 | 1,493
dermatomyositis 3 | 933
ductal carcinoma in situ 3 | 1,745
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
medulloblastoma 3 | 1,524
non-small cell lung cancer 3 | 2,798
oligodendroglioma 3 | 2,849
ovarian neoplasm 3 | 97
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pilocytic astrocytoma 3 | 3,086
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 674
subependymal giant cell astrocytoma 3 | 2,287
Adenoid Cystic Carcinoma 2 | 99
Cholangiocarcinoma 2 | 32
Colon Carcinoma 2 | 25
Colonic Neoplasms 2 | 126
Endometriosis 2 | 535
Familial adenomatous polyposis 2 | 31
Growth Disorders 2 | 33
Head and neck squamous cell carcinoma 2 | 12
Hepatitis C 2 | 90
IGA Glomerulonephritis 2 | 454
Juvenile arthritis 2 | 124
Liver Cirrhosis 2 | 101
Liver neoplasms 2 | 109
Lymphoma 2 | 56
Lynch syndrome 2 | 33
Pancreatitis 2 | 97
Parkinson's disease 2 | 364
Precancerous Conditions 2 | 69
Thyroid Neoplasm 2 | 33
Vascular disease 2 | 281
acute quadriplegic myopathy 2 | 1,157
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
hepatocellular carcinoma 2 | 532
nasopharyngeal carcinoma 2 | 1,056
spina bifida 2 | 1,064

Tissue

Blood and immune system 19 | 17,995
Cardiovascular System 19 | 17,958
Digestive Tract 19 | 18,473
Endocrine System 19 | 18,512
Female tissues 19 | 18,647
Liver and Pancreas 19 | 18,136
Male tissues 19 | 17,969
Nervous System 19 | 18,561
Respiratory system 19 | 17,484
Skin and soft tissues 19 | 18,115
Urinary Tract 19 | 18,444

Target Family

Non-IDG 11 | 11,971
Enzyme 5 | 4,146
Kinase 3 | 634

Reactome Pathway

Signaling by EGFR in Cancer 19 | 19
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
GTPase HRas HRAS Tchem Enzyme -3.97914 9497.9 312
GTPase NRas NRAS Tchem Enzyme -2.95682 880.4 265
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74376 4837.7 851
Polyubiquitin-C UBC Tbio Non-IDG -2.87012 56.7 130
Polyubiquitin-B UBB Tbio Non-IDG 92.3 370