Development Level

Tbio 26 | 11,178
Tchem 13 | 1,885
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased leukocyte cell numbe... 2 | 73
embryonic lethality prior to t... 2 | 278
short tibia 2 | 97
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal tail morphology 1 | 25
abnormal vibrissa morphology 1 | 25
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating serum al... 1 | 82
decreased mean corpuscular hem... 1 | 50
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased heart left ventricle... 1 | 4
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
prenatal lethality 1 | 28

Disease

Carcinoma 33 | 11,192
ovarian cancer 30 | 8,297
glioblastoma 27 | 5,635
osteosarcoma 27 | 7,766
Cancer 24 | 2,388
medulloblastoma, large-cell 20 | 6,086
atypical teratoid / rhabdoid tumor 19 | 4,971
lung cancer 19 | 4,607
psoriasis 19 | 6,514
Kidney cancer 15 | 2,548
oligodendroglioma 15 | 2,768
astrocytic glioma 14 | 2,530
Breast cancer 13 | 3,469
ependymoma 13 | 4,559
group 3 medulloblastoma 12 | 4,002
Pick disease 11 | 1,856
adult high grade glioma 11 | 3,701
subependymal giant cell astrocytoma 11 | 2,230
Astrocytoma, Pilocytic 10 | 3,006
primitive neuroectodermal tumor 10 | 2,957
juvenile dermatomyositis 9 | 1,147
malignant mesothelioma 9 | 3,135
pediatric high grade glioma 9 | 1,035
pituitary cancer 9 | 1,915
Hypoplastic mandible condyle 8 | 273
Mandibular hypoplasia 8 | 273
Micrognathism 8 | 273
Rheumatoid arthritis 8 | 1,156
breast carcinoma 8 | 1,589
group 4 medulloblastoma 8 | 1,806
interstitial cystitis 8 | 2,237
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,204
invasive ductal carcinoma 8 | 2,867
non-small cell lung cancer 8 | 2,799
pancreatic cancer 8 | 2,322
Downward slant of palpebral fissure 7 | 158
Muscle hypotonia 7 | 562
Noonan syndrome 7 | 34
Orbital separation excessive 7 | 240
primary pancreatic ductal adenocarcinoma 7 | 1,071
tuberculosis 7 | 1,963
Autosomal recessive predisposition 6 | 1,407
Blepharoptosis 6 | 229
Breast Neoplasms 6 | 423
Byzanthine arch palate 6 | 194
Congenital Epicanthus 6 | 175
Cryptorchidism 6 | 287
Delayed bone age 6 | 132
Frontal bossing 6 | 154
Intellectual disability 6 | 998
Joint hyperflexibility 6 | 76
Mammary Neoplasms 6 | 403
Melanoma 6 | 689
Multiple myeloma 6 | 1,296
Neck webbing 6 | 35
Pectus excavatum 6 | 100
Schizophrenia 6 | 1,136
Stomach Neoplasms 6 | 287
Triangular face 6 | 57
dermatomyositis 6 | 941
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,872
lung adenocarcinoma 6 | 2,627
lung carcinoma 6 | 2,755
progressive supranuclear palsy 6 | 656
ulcerative colitis 6 | 1,765
Acquired scoliosis 5 | 274
Adenocarcinoma of lung 5 | 140
Carcinoma, Hepatocellular 5 | 217
Cardiac Arrhythmia 5 | 101
Cardiac conduction abnormalities 5 | 78
Colorectal Neoplasms 5 | 235
Concave bridge of nose 5 | 191
Conduction disorder of the heart 5 | 79
Curvature of spine 5 | 275
Depressed nasal bridge 5 | 191
Depressed nasal root/bridge 5 | 191
EKG abnormalities 5 | 78
Electrocardiogram abnormal 5 | 81
Electrocardiogram change 5 | 78
Epilepsy 5 | 775
High forehead 5 | 101
Immune system cancer 5 | 136
Liver carcinoma 5 | 229
Low set ears 5 | 178
Lung Neoplasms 5 | 217
Melanocytic nevus 5 | 43
Neoplasm Metastasis 5 | 160
Noncancerous mole 5 | 28
Seizures 5 | 584
Short neck 5 | 139
Short stature 5 | 514
Squamous cell carcinoma 5 | 125
Strabismus 5 | 265
Tall forehead 5 | 101
Ventricular Septal Defects 5 | 113
acute quadriplegic myopathy 5 | 1,133
astrocytoma 5 | 1,113
hepatocellular carcinoma 5 | 536
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,911

Tissue

Blood and immune system 42 | 16,909
Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Male tissues 42 | 17,142
Nervous System 42 | 16,725
Respiratory system 42 | 16,393
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678
Cardiovascular System 41 | 15,192
Liver and Pancreas 41 | 16,750

Target Family

Non-IDG 23 | 12,091
Enzyme 14 | 4,145
Kinase 5 | 634

Reactome Pathway

Signaling by EGFR 42 | 42
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Disintegrin and metalloproteinase domain-containing protein 12 ADAM12 Tchem Enzyme -2.28901 214.1 347
Tyrosine-protein phosphatase non-receptor type 3 PTPN3 Tbio Enzyme -1.40961 29.1 162
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
GTPase KRas KRAS Tbio Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Endophilin-A2 SH3GL1 Tbio Non-IDG -2.15479 134.2 257