Development Level

Tbio 192 | 10,625
Tchem 104 | 1,890
Tclin 53 | 602
Tdark 7 | 7,003

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 17 | 633
decreased body weight 12 | 174
decreased total body fat amoun... 11 | 186
abnormal behavior 7 | 226
decreased lean body mass 7 | 195
embryonic lethality prior to t... 7 | 187
abnormal embryo size 6 | 112
decreased body length 6 | 108
decreased circulating choleste... 6 | 85
abnormal bone structure 5 | 131
decreased bone mineral content 5 | 157
decreased circulating HDL chol... 5 | 77
decreased lumbar vertebrae num... 5 | 62
enlarged heart 5 | 111
abnormal retina morphology 4 | 100
abnormal retinal pigmentation 4 | 61
decreased circulating LDL chol... 4 | 37
decreased circulating alanine ... 4 | 53
decreased grip strength 4 | 123
increased mean corpuscular hem... 4 | 93
thrombocytopenia 4 | 46
abnormal forebrain development 3 | 18
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 121
decreased circulating total pr... 3 | 41
decreased circulating triglyce... 3 | 83
decreased kidney weight 3 | 7
hypoactivity 3 | 89
increased circulating HDL chol... 3 | 63
increased circulating LDL chol... 3 | 15
increased circulating alkaline... 3 | 119
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal lens morphology 2 | 73
abnormal seminal vesicle morph... 2 | 47
abnormal tail morphology 2 | 17
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
decreased caudal vertebrae num... 2 | 49
decreased circulating chloride... 2 | 32
decreased circulating creatini... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased leukocyte cell numbe... 2 | 54
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
impaired pupillary reflex 2 | 14
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating phosphat... 2 | 24
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
increased startle reflex 2 | 38
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal coat appearance 1 | 25
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased mean corpuscular hem... 1 | 34
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
female infertility 1 | 34
impaired righting response 1 | 19
increased body length 1 | 20
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
thrombocytosis 1 | 23
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 205 | 7,933
ovarian cancer 203 | 8,484
glioblastoma 160 | 5,572
medulloblastoma, large-cell 155 | 6,234
psoriasis 154 | 6,685
Cancer 147 | 2,346
lung cancer 133 | 4,466
atypical teratoid / rhabdoid tumor 113 | 4,369
oligodendroglioma 92 | 2,849
pilocytic astrocytoma 90 | 3,086
malignant mesothelioma 89 | 3,162
Breast cancer 88 | 3,094
pediatric high grade glioma 85 | 2,712
Carcinoma 80 | 2,147
invasive ductal carcinoma 80 | 2,950
subependymal giant cell astrocytoma 80 | 2,287
ependymoma 79 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 76 | 3,289
primitive neuroectodermal tumor 74 | 3,031
interstitial cystitis 71 | 2,299
astrocytic glioma 70 | 2,241
lung adenocarcinoma 69 | 2,713
lung carcinoma 66 | 2,844
non-small cell lung cancer 63 | 2,798
ulcerative colitis 63 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 62 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 61 | 2,988
pancreatic cancer 58 | 2,300
Pick disease 55 | 1,893
Multiple myeloma 53 | 1,327
pituitary cancer 53 | 1,972
diabetes mellitus 52 | 1,663
tuberculosis 52 | 1,557
group 4 medulloblastoma 51 | 1,875
group 3 medulloblastoma 49 | 2,254
astrocytoma 48 | 1,493
medulloblastoma 47 | 1,524
Rheumatoid Arthritis 46 | 1,160
cystic fibrosis 46 | 1,665
adult high grade glioma 42 | 2,148
breast carcinoma 40 | 1,614
ductal carcinoma in situ 40 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,795
juvenile dermatomyositis 37 | 1,189
colon cancer 34 | 1,475
Schizophrenia 33 | 501
primary pancreatic ductal adenocarcinoma 33 | 1,271
atypical teratoid/rhabdoid tumor 31 | 1,095
Mammary Neoplasms 30 | 410
cutaneous lupus erythematosus 30 | 1,056
Prostatic Neoplasms 29 | 471
adrenocortical carcinoma 29 | 1,427
dermatomyositis 29 | 933
primary Sjogren syndrome 29 | 789
Parkinson's disease 28 | 364
spina bifida 28 | 1,064
posterior fossa group B ependymoma 27 | 1,530
Alzheimer's disease 26 | 644
gastric carcinoma 26 | 832
posterior fossa group A ependymoma 26 | 1,511
Intellectual disability 25 | 573
Obesity 25 | 616
Waldenstrons macroglobulinemia 25 | 765
acute quadriplegic myopathy 24 | 1,157
non-small cell lung carcinoma 24 | 413
Lung Neoplasms 23 | 171
Vascular disease 22 | 281
HIV Infections 21 | 100
esophageal adenocarcinoma 21 | 737
pancreatic carcinoma 21 | 567
Liver carcinoma 20 | 217
Polycystic Ovary Syndrome 20 | 332
non primary Sjogren syndrome sicca 20 | 840
Asthma 19 | 349
Renal Cell Carcinoma 19 | 199
progressive supranuclear palsy 19 | 674
sonic hedgehog group medulloblastoma 19 | 1,482
tuberculosis and treatment for 6 months 19 | 686
Anemia 18 | 252
Autistic Disorder 18 | 320
Down syndrome 18 | 548
Multiple Sclerosis 18 | 498
Stomach Neoplasms 18 | 282
Melanoma 17 | 261
sarcoidosis 17 | 358
Adenoma 16 | 165
Animal Mammary Neoplasms 16 | 136
Duchenne muscular dystrophy 16 | 602
Kidney disease 16 | 396
Mammary Neoplasms, Experimental 16 | 150
Osteoporosis 16 | 257
acute myeloid leukemia 16 | 780
fibroadenoma 16 | 557
hepatocellular carcinoma 16 | 532
nasopharyngeal carcinoma 16 | 1,056
Heart disease 15 | 279
Neoplasm Invasiveness 15 | 127
Noonan Syndrome 15 | 33
Peripheral Neuropathy 15 | 303
gastric cancer 15 | 430

Tissue

Endocrine System 356 | 18,512
Female tissues 356 | 18,647
Nervous System 356 | 18,561
Digestive Tract 355 | 18,473
Urinary Tract 355 | 18,444
Liver and Pancreas 354 | 18,136
Blood and immune system 353 | 17,995
Cardiovascular System 352 | 17,958
Skin and soft tissues 352 | 18,115
Male tissues 351 | 17,969
Respiratory system 346 | 17,484

Target Family

Non-IDG 155 | 11,971
Enzyme 120 | 4,146
Kinase 67 | 634
Ion Channel 8 | 341
Transcription Factor 5 | 1,400
Nuclear Receptor 1 | 48

Reactome Pathway

Signaling by EGFR 356 | 356
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416