Development Level

Tbio 33 | 11,445
Tchem 14 | 1,598
Tclin 8 | 613
Tdark 2 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 4 | 207
preweaning lethality, incomple... 3 | 499
decreased body weight 2 | 161
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased prepulse inhibition 1 | 82
enlarged heart 1 | 210
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
prenatal lethality 1 | 28
vertebral transformation 1 | 12

Disease

Carcinoma 48 | 11,493
osteosarcoma 37 | 7,950
ovarian cancer 35 | 8,520
Cancer 30 | 2,499
glioblastoma 28 | 5,792
lung cancer 27 | 4,740
atypical teratoid / rhabdoid tumor 26 | 5,112
ependymoma 22 | 4,679
medulloblastoma, large-cell 22 | 6,241
psoriasis 22 | 6,694
Kidney cancer 21 | 2,613
Breast cancer 18 | 3,578
adult high grade glioma 18 | 3,801
astrocytic glioma 17 | 2,597
group 3 medulloblastoma 16 | 4,104
Astrocytoma, Pilocytic 15 | 3,081
malignant mesothelioma 14 | 3,232
oligodendroglioma 14 | 2,850
pancreatic cancer 14 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
lung adenocarcinoma 13 | 2,716
primitive neuroectodermal tumor 13 | 3,035
tuberculosis 13 | 2,010
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
invasive ductal carcinoma 12 | 2,951
subependymal giant cell astrocytoma 12 | 2,287
Multiple myeloma 11 | 1,332
Short stature 11 | 531
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
ulcerative colitis 11 | 1,819
Autosomal recessive predisposition 10 | 1,442
Blepharoptosis 10 | 231
Byzanthine arch palate 10 | 194
Intellectual disability 10 | 1,016
Muscle hypotonia 10 | 571
Schizophrenia 10 | 1,160
Strabismus 10 | 270
diabetes mellitus 10 | 1,728
interstitial cystitis 10 | 2,312
lung carcinoma 10 | 2,843
non-small cell lung cancer 10 | 2,890
Bleeding tendency 9 | 37
juvenile dermatomyositis 9 | 1,187
Acquired scoliosis 8 | 281
Cardiomyopathy 8 | 116
Cognitive delay 8 | 608
Curvature of spine 8 | 282
Dull intelligence 8 | 645
Gastrointestinal Hemorrhage 8 | 52
Global developmental delay 8 | 608
Hepatomegaly 8 | 285
Liver Cirrhosis, Experimental 8 | 769
Low intelligence 8 | 645
Lung Neoplasms 8 | 232
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Noonan syndrome 8 | 34
Orbital separation excessive 8 | 244
Osteoporosis 8 | 363
Poor school performance 8 | 645
primary pancreatic ductal adenocarcinoma 8 | 1,109
Abnormal dermatoglyphic pattern 7 | 24
Aortic coarctation 7 | 30
Chubby cheeks 7 | 50
Cryptorchidism 7 | 296
Downward slant of palpebral fissure 7 | 158
Epistaxis 7 | 43
Full cheeks 7 | 50
Hyperplasia of cheeks 7 | 50
Hypertrophic Cardiomyopathy 7 | 117
Hypertrophy of cheeks 7 | 50
Hypoplastic mandible condyle 7 | 275
Joint hyperflexibility 7 | 78
Large auricle 7 | 87
Large dysplastic ears 7 | 87
Large pinnae 7 | 87
Large prominent ears 7 | 87
Large protruding ears 7 | 87
Large, floppy ears 7 | 87
Low set ears 7 | 181
Macrotia 7 | 87
Mammary Neoplasms 7 | 425
Mandibular hypoplasia 7 | 275
Melanoma 7 | 711
Micrognathism 7 | 275
Neck webbing 7 | 35
Pick disease 7 | 1,894
Premature Birth 7 | 77
Premature birth of newborn 7 | 67
Puffy cheeks 7 | 50
Renal Cell Carcinoma 7 | 214
Stomach Neoplasms 7 | 300
ductal carcinoma in situ 7 | 1,745
Failure to gain weight 6 | 365
acute quadriplegic myopathy 6 | 1,158
astrocytoma 6 | 1,146
cystic fibrosis 6 | 1,696
dermatomyositis 6 | 966

Tissue

Blood and immune system 57 | 16,909
Digestive Tract 57 | 17,369
Endocrine System 57 | 18,159
Female tissues 57 | 17,400
Liver and Pancreas 57 | 16,750
Male tissues 57 | 17,142
Respiratory system 57 | 16,393
Skin and soft tissues 57 | 17,230
Urinary Tract 57 | 16,678
Cardiovascular System 56 | 15,192
Nervous System 55 | 16,725

Target Family

Non-IDG 27 | 12,091
Enzyme 13 | 4,145
Kinase 13 | 634
Epigenetic 3 | 242
Ion Channel 1 | 344

Reactome Pathway

Signaling by BRAF and RAF fusi... 57 | 57
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Connector enhancer of kinase suppressor of ras 2 CNKSR2 Tbio Enzyme -1.11551 14.5 71
Staphylococcal nuclease domain-containing protein 1 SND1 Tbio Epigenetic -2.35812 225.9 175
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Transcription intermediary factor 1-alpha TRIM24 Tchem Epigenetic -2.15509 143.0 372
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328