Development Level

Tbio 22 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
decreased circulating creatini... 2 | 39
decreased startle reflex 2 | 75
hypoactivity 2 | 132
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal placement of pupils 1 | 6
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lymphocyte cell numb... 1 | 32
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 12
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

ovarian cancer 18 | 8,520
Carcinoma 17 | 11,493
medulloblastoma, large-cell 14 | 6,241
osteosarcoma 13 | 7,950
atypical teratoid / rhabdoid tumor 10 | 5,112
ependymoma 10 | 4,679
oligodendroglioma 10 | 2,850
psoriasis 10 | 6,694
Cancer 9 | 2,499
Pick disease 9 | 1,894
glioblastoma 9 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
invasive ductal carcinoma 9 | 2,951
lung carcinoma 8 | 2,843
non-small cell lung cancer 8 | 2,890
Breast cancer 7 | 3,578
astrocytic glioma 7 | 2,597
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Fibrodysplasia ossificans progressiva 6 | 17
Hereditary hemorrhagic telangiectasia 6 | 13
adult high grade glioma 6 | 3,801
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
breast carcinoma 6 | 1,638
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
juvenile dermatomyositis 6 | 1,187
lung adenocarcinoma 6 | 2,716
primitive neuroectodermal tumor 6 | 3,035
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Astrocytoma, Pilocytic 5 | 3,081
Brachydactyly 5 | 156
Duchenne muscular dystrophy 5 | 601
active Crohn's disease 5 | 922
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis 5 | 1,696
lung cancer 5 | 4,740
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972
Atopic dermatitis 4 | 952
Craniofacial Abnormalities 4 | 151
Hypoplastic feet 4 | 66
Myopia 4 | 176
Primary pulmonary hypertension 4 | 14
Rheumatoid arthritis 4 | 1,191
Short stature 4 | 531
Simple syndactyly of toes, first web space 4 | 23
Telangiectasis 4 | 36
colon cancer 4 | 1,478
ductal carcinoma in situ 4 | 1,745
pediatric high grade glioma 4 | 1,064
Anemia 3 | 365
Aplasia/Hypoplasia of the middle phalanges of the toes 3 | 5
Autosomal recessive predisposition 3 | 1,442
Bilateral fifth finger clinodactyly 3 | 110
Cholecystitis 3 | 18
Craniosynostosis 3 | 74
Curvature of little finger 3 | 110
Decreased projection of maxilla 3 | 66
Deficiency of upper jaw bones 3 | 66
Epilepsy 3 | 792
Epistaxis 3 | 43
Failure to gain weight 3 | 365
Familial primary pulmonary hypertension 3 | 11
Female Urogenital Diseases 3 | 18
Hemangioma, Cavernous 3 | 20
Hemoglobin low 3 | 124
Hypertension, Portal 3 | 22
Hypertensive disease 3 | 292
Hypoplasia of the maxilla 3 | 66
Hypotrophic maxilla 3 | 66
Increase in blood pressure 3 | 119
Intermittent migraine headaches 3 | 68
Iron-Refractory Iron Deficiency Anemia 3 | 15
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Maxillary retrognathia 3 | 66
Microstomia 3 | 78
Migraine Disorders 3 | 76
Multiple myeloma 3 | 1,332
Multiple synostoses syndrome 3 | 9
Pediatric failure to thrive 3 | 365
Pulmonary hypertension 3 | 85
Radially deviated fingers 3 | 38
Retrusion of upper jaw bones 3 | 66
Seizures 3 | 596
Spontaneous haematoma 3 | 8
Strabismus 3 | 270
Telangiectasia of the skin 3 | 39
Visceral angiomatosis 3 | 13
aldosterone-producing adenoma 3 | 665
astrocytoma 3 | 1,146
interstitial cystitis 3 | 2,312
limb girdle muscular dystrophy 2A 3 | 213
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primary pancreatic ductal adenocarcinoma 3 | 1,109
pulmonary arterial hypertension 3 | 75

Tissue

Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Digestive Tract 25 | 17,369
Skin and soft tissues 25 | 17,230
Male tissues 24 | 17,142
Urinary Tract 24 | 16,678
Blood and immune system 23 | 16,909
Cardiovascular System 23 | 15,192
Nervous System 23 | 16,725
Respiratory system 23 | 16,393

Target Family

Non-IDG 13 | 12,091
Kinase 6 | 634
Transcription Factor 6 | 1,400
Enzyme 2 | 4,145

Reactome Pathway

Signaling by BMP 27 | 27
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Growth/differentiation factor 2 GDF2 Tbio Non-IDG -2.16825 176.4 239
Follistatin-related protein 1 FSTL1 Tbio Non-IDG -1.98038 117.5 265
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.43406 2729.3 264
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.65728 4647.9 684
Bone morphogenetic protein receptor type-1B BMPR1B Tchem Kinase -2.00303 86.8 498
Bone morphogenetic protein receptor type-1A BMPR1A Tchem Kinase -2.34984 211.0 622
Zinc finger FYVE domain-containing protein 16 ZFYVE16 Tbio Non-IDG -0.84581 9.36 116
Bone morphogenetic protein 10 BMP10 Tbio Non-IDG -1.43436 26.2 268