Development Level

Tbio 7 | 11,445
Tclin 7 | 613
Tchem 6 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

decreased body weight 2 | 161
preweaning lethality, complete... 2 | 979
abnormal anxiety-related respo... 1 | 1
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal social-conspecific in... 1 | 3
decreased bone mineral content 1 | 151
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased blood urea nitrogen ... 1 | 48
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
thin ventricular wall 1 | 24

Disease

Carcinoma 18 | 11,493
Cancer 16 | 2,499
osteosarcoma 16 | 7,950
ovarian cancer 14 | 8,520
glioblastoma 13 | 5,792
Astrocytoma, Pilocytic 9 | 3,081
atypical teratoid / rhabdoid tumor 9 | 5,112
Carcinoma, Squamous Cell 8 | 110
Squamous cell carcinoma 8 | 129
tuberculosis 8 | 2,010
Breast cancer 7 | 3,578
Kidney cancer 7 | 2,613
ependymoma 7 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung cancer 7 | 4,740
malignant mesothelioma 7 | 3,232
oligodendroglioma 7 | 2,850
primitive neuroectodermal tumor 7 | 3,035
subependymal giant cell astrocytoma 7 | 2,287
Neoplasm Invasiveness 6 | 161
Schizophrenia 6 | 1,160
adult high grade glioma 6 | 3,801
astrocytic glioma 6 | 2,597
group 3 medulloblastoma 6 | 4,104
medulloblastoma, large-cell 6 | 6,241
Dull intelligence 5 | 645
Gliosis 5 | 56
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mental Depression 5 | 333
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Neoplasm Metastasis 5 | 168
Pick disease 5 | 1,894
Poor school performance 5 | 645
Short stature 5 | 531
colon cancer 5 | 1,478
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
psoriasis 5 | 6,694
Arthritis 4 | 290
Bipolar Disorder 4 | 666
Cognitive delay 4 | 608
Depressive disorder 4 | 409
Global developmental delay 4 | 608
Lung Neoplasms 4 | 232
Major Depressive Disorder 4 | 301
Melanoma 4 | 711
Mental and motor retardation 4 | 608
Multiple Sclerosis 4 | 540
Prostatic Neoplasms 4 | 495
Renal Cell Carcinoma 4 | 214
Stomach Neoplasms 4 | 300
Strabismus 4 | 270
Unipolar Depression 4 | 250
Vascular disease 4 | 319
breast carcinoma 4 | 1,638
gastric carcinoma 4 | 807
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
non-small cell lung carcinoma 4 | 317
pediatric high grade glioma 4 | 1,064
Anemia 3 | 365
Anteverted nostril 3 | 191
Blepharoptosis 3 | 231
Brain Ischemia 3 | 110
Byzanthine arch palate 3 | 194
Cardiomyopathy, Dilated 3 | 83
Cerebrovascular accident 3 | 63
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Endometriosis 3 | 540
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Failure to thrive in infancy 3 | 32
Frontal bossing 3 | 157
High forehead 3 | 102
Liver Cirrhosis, Experimental 3 | 769
Long philtrum 3 | 137
Multiple myeloma 3 | 1,332
Pediatric failure to thrive 3 | 365
Premature Birth 3 | 77
Premature birth of newborn 3 | 67
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Short nose 3 | 132
Skin cancer 3 | 469
Small nose 3 | 132
Stroke 3 | 33
Tall forehead 3 | 102
ductal carcinoma in situ 3 | 1,745
hereditary spastic paraplegia 3 | 318
lung adenocarcinoma 3 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972

Tissue

Blood and immune system 20 | 16,909
Cardiovascular System 20 | 15,192
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678

Target Family

Non-IDG 10 | 12,091
Kinase 9 | 634
Enzyme 1 | 4,145

Reactome Pathway

Signal transduction by L1 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.13063 1294.7 1785
Integrin alpha-5 ITGA5 Tbio Non-IDG -2.29130 169.1 826
Integrin alpha-IIb ITGA2B Tclin Non-IDG -3.52120 3309.8 1170
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Casein kinase II subunit beta CSNK2B Tbio Kinase -2.72925 527.4 422
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Integrin alpha-9 ITGA9 Tbio Non-IDG -1.46619 29.0 124