Development Level

Tbio 21 | 11,651
Tdark 4 | 6,593
Tchem 3 | 1,388
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
abnormal behavior 1 | 298
abnormal femur morphology 1 | 14
abnormal spleen morphology 1 | 55
decreased lean body mass 1 | 135
enlarged heart 1 | 210
enlarged spleen 1 | 41
preweaning lethality, complete... 1 | 979
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

glioblastoma 19 | 5,792
medulloblastoma, large-cell 19 | 6,241
ovarian cancer 17 | 8,519
osteosarcoma 16 | 7,950
Carcinoma 15 | 11,493
atypical teratoid / rhabdoid tumor 15 | 5,112
ependymoma 15 | 4,679
psoriasis 12 | 6,694
Breast cancer 11 | 3,577
group 3 medulloblastoma 11 | 4,104
Astrocytoma, Pilocytic 10 | 3,081
primitive neuroectodermal tumor 10 | 3,035
adult high grade glioma 9 | 3,801
invasive ductal carcinoma 9 | 2,950
subependymal giant cell astrocytoma 9 | 2,287
Pick disease 8 | 1,894
group 4 medulloblastoma 8 | 1,855
lung carcinoma 8 | 2,843
non-small cell lung cancer 8 | 2,890
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
active Crohn's disease 7 | 922
lung cancer 7 | 4,740
breast carcinoma 6 | 1,637
ductal carcinoma in situ 6 | 1,744
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,954
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
juvenile dermatomyositis 6 | 1,187
lung adenocarcinoma 6 | 2,716
tuberculosis 6 | 2,010
Rheumatoid arthritis 5 | 1,191
active ulcerative colitis 5 | 764
astrocytic glioma 5 | 2,597
colon cancer 5 | 1,478
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,290
malignant mesothelioma 5 | 3,232
pituitary cancer 5 | 1,972
ulcerative colitis 5 | 1,819
Cancer 4 | 2,499
Duchenne muscular dystrophy 4 | 601
Liver Cirrhosis, Experimental 4 | 769
acute quadriplegic myopathy 4 | 1,158
astrocytoma 4 | 1,146
pediatric high grade glioma 4 | 1,064
primary Sjogren syndrome 4 | 735
sarcoidosis 4 | 370
Breast Neoplasms 3 | 445
Colorectal Neoplasms 3 | 243
Coronary artery disease 3 | 268
Intellectual disability 3 | 1,016
Mammary Neoplasms 3 | 425
Multiple myeloma 3 | 1,332
Schizophrenia 3 | 1,160
adrenocortical carcinoma 3 | 1,428
cystic fibrosis 3 | 1,695
gastric cancer 3 | 459
pancreatic carcinoma 3 | 562
primary pancreatic ductal adenocarcinoma 3 | 1,108
Alzheimer's disease 2 | 658
Amnesia 2 | 17
Arthritis 2 | 290
Asthma 2 | 385
Big calvaria 2 | 147
Bipolar Disorder 2 | 666
Blastic phase chronic myeloid leukemia 2 | 58
Blood Platelet Disorders 2 | 3
Cerebrovascular disease 2 | 238
Charcot-Marie-Tooth disease dominant intermediate F 2 | 3
Chronic Myelocytic Leukemia Accelerated Phase 2 | 59
Chronic phase chronic myeloid leukemia 2 | 45
Depressive disorder 2 | 409
Epilepsy 2 | 792
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Mental Depression 2 | 333
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 2 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 2 | 47
Seizures 2 | 596
Thrombosis 2 | 46
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
hepatocellular carcinoma 2 | 547
mucosa-associated lymphoid tissue lymphoma 2 | 484
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
progressive supranuclear palsy 2 | 676
spina bifida 2 | 1,074
Acute coronary syndrome 1 | 39
Albuminuria 1 | 21
Bloom syndrome 1 | 29
Noonan syndrome 1 | 34
Papule 1 | 43
Patellar tendinitis 1 | 2
Polycystic Kidney, Autosomal Recessive 1 | 9
Sensory peripheral neuropathy 1 | 10

Tissue

Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Blood and immune system 30 | 16,909
Female tissues 29 | 17,400
Male tissues 29 | 17,142
Nervous System 29 | 16,725
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678
Cardiovascular System 28 | 15,192
Liver and Pancreas 28 | 16,750
Respiratory system 28 | 16,393

Target Family

Non-IDG 25 | 12,091
GPCR 3 | 408
Kinase 2 | 634
Enzyme 1 | 4,145

Reactome Pathway

Signal amplification 31 | 31
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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