Development Level

Tbio 1,449 | 11,445
Tdark 498 | 6,588
Tchem 480 | 1,598
Tclin 230 | 613

Collection

GPCR: IDG Consortium (Targets) 63 | 126
RFA-RM-18-021 51 | 328
Kinase: IDG Consortium (Target... 14 | 125
GPCR: IDG Consortium (Complete... 13 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 176 | 979
preweaning lethality, incomple... 77 | 499
embryonic lethality prior to t... 51 | 278
abnormal behavior 46 | 298
enlarged heart 45 | 210
abnormal embryo size 41 | 220
decreased vertical activity 39 | 208
decreased total body fat amoun... 37 | 207
abnormal bone structure 36 | 187
decreased body weight 36 | 161
abnormal heart morphology 32 | 162
embryonic lethality prior to o... 32 | 239
decreased bone mineral content 29 | 151
increased total body fat amoun... 29 | 134
decreased lean body mass 26 | 135
hypoactivity 26 | 132
increased lean body mass 26 | 172
increased startle reflex 25 | 112
hyperactivity 22 | 148
embryonic growth retardation 20 | 106
decreased circulating choleste... 19 | 93
increased circulating alkaline... 19 | 122
abnormal seminal vesicle morph... 18 | 114
cataract 18 | 92
decreased mean corpuscular vol... 18 | 79
decreased bone mineral density 17 | 126
decreased circulating glucose ... 17 | 126
increased mean corpuscular vol... 17 | 92
short tibia 17 | 97
decreased circulating serum al... 16 | 82
decreased lymphocyte cell numb... 16 | 83
decreased prepulse inhibition 16 | 82
edema 16 | 59
impaired glucose tolerance 15 | 75
improved glucose tolerance 15 | 79
increased bone mineral content 15 | 108
increased circulating HDL chol... 15 | 80
male infertility 15 | 123
abnormal kidney morphology 14 | 65
abnormal retina morphology 14 | 71
prenatal lethality prior to he... 14 | 87
decreased circulating insulin ... 13 | 76
decreased fasted circulating g... 13 | 65
decreased grip strength 13 | 116
decreased hemoglobin content 13 | 68
decreased startle reflex 13 | 75
increased blood urea nitrogen ... 13 | 48
increased neutrophil cell numb... 13 | 46
small superior vagus ganglion 13 | 74
decreased body length 12 | 101
increased circulating sodium l... 12 | 71
increased circulating triglyce... 12 | 42
increased monocyte cell number 12 | 63
small testis 12 | 58
abnormal gait 11 | 69
abnormal lens morphology 11 | 81
abnormal neural tube closure 11 | 46
abnormal skin morphology 11 | 50
abnormal testis morphology 11 | 43
decreased circulating amylase ... 11 | 28
decreased circulating triglyce... 11 | 79
decreased neutrophil cell numb... 11 | 42
increased circulating choleste... 11 | 66
increased fasted circulating g... 11 | 76
increased mean corpuscular hem... 11 | 96
limb grasping 11 | 41
microphthalmia 11 | 26
persistence of hyaloid vascula... 11 | 33
thrombocytopenia 11 | 56
abnormal coat-hair pigmentatio... 10 | 64
abnormal eye morphology 10 | 68
abnormal pericardium morpholog... 10 | 26
decreased caudal vertebrae num... 10 | 53
decreased circulating HDL chol... 10 | 68
decreased circulating LDL chol... 10 | 38
decreased circulating total pr... 10 | 49
decreased hematocrit 10 | 46
decreased mean corpuscular hem... 10 | 50
female infertility 10 | 60
increased circulating calcium ... 10 | 34
increased hemoglobin content 10 | 45
increased leukocyte cell numbe... 10 | 47
increased lymphocyte cell numb... 10 | 32
increased mean platelet volume 10 | 45
increased or absent threshold ... 10 | 101
prolonged QT interval 10 | 38
prolonged ST segment 10 | 36
abnormal sleep behavior 9 | 70
decreased circulating creatini... 9 | 39
decreased circulating iron lev... 9 | 32
decreased leukocyte cell numbe... 9 | 73
impaired righting response 9 | 26
increased circulating creatini... 9 | 38
increased heart weight 9 | 62
abnormal cornea morphology 8 | 31
anophthalmia 8 | 33
decreased circulating alanine ... 8 | 47
decreased circulating fructosa... 8 | 30
impaired pupillary reflex 8 | 26
pallor 8 | 34

Disease

Carcinoma 1,859 | 11,493
ovarian cancer 1,177 | 8,520
osteosarcoma 1,089 | 7,950
psoriasis 1,011 | 6,694
glioblastoma 934 | 5,792
medulloblastoma, large-cell 912 | 6,241
atypical teratoid / rhabdoid tumor 793 | 5,112
lung cancer 784 | 4,740
Cancer 727 | 2,499
ependymoma 710 | 4,679
Breast cancer 617 | 3,578
adult high grade glioma 607 | 3,801
group 3 medulloblastoma 570 | 4,104
malignant mesothelioma 546 | 3,232
Astrocytoma, Pilocytic 514 | 3,081
invasive ductal carcinoma 514 | 2,951
primitive neuroectodermal tumor 501 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 487 | 3,291
non-small cell lung cancer 485 | 2,890
lung adenocarcinoma 467 | 2,716
lung carcinoma 466 | 2,843
Kidney cancer 463 | 2,613
oligodendroglioma 458 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 454 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 422 | 2,955
interstitial cystitis 417 | 2,312
astrocytic glioma 392 | 2,597
pancreatic cancer 385 | 2,398
subependymal giant cell astrocytoma 372 | 2,287
diabetes mellitus 367 | 1,728
ulcerative colitis 326 | 1,819
breast carcinoma 319 | 1,638
Schizophrenia 316 | 1,160
pituitary cancer 316 | 1,972
ductal carcinoma in situ 315 | 1,745
tuberculosis 306 | 2,010
group 4 medulloblastoma 301 | 1,855
Pick disease 293 | 1,894
cystic fibrosis 278 | 1,696
colon cancer 265 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 249 | 1,962
astrocytoma 229 | 1,146
adrenocortical carcinoma 228 | 1,428
Rheumatoid arthritis 224 | 1,191
Autosomal recessive predisposition 218 | 1,442
Multiple myeloma 212 | 1,332
Obesity 211 | 678
Bipolar Disorder 204 | 666
juvenile dermatomyositis 191 | 1,187
acute quadriplegic myopathy 183 | 1,158
cutaneous lupus erythematosus 179 | 1,057
pediatric high grade glioma 177 | 1,064
Intellectual disability 172 | 1,016
primary pancreatic ductal adenocarcinoma 172 | 1,109
Depressive disorder 164 | 409
dermatomyositis 164 | 966
Breast Neoplasms 159 | 445
Liver Cirrhosis, Experimental 158 | 769
spina bifida 155 | 1,074
Mammary Neoplasms 153 | 425
Atopic dermatitis 151 | 952
Epilepsy 146 | 792
Alzheimer's disease 145 | 658
Hypertension 144 | 396
nasopharyngeal carcinoma 143 | 1,058
primary Sjogren syndrome 138 | 735
Melanoma 134 | 711
Endometriosis 133 | 540
Seizures 132 | 596
Mental Depression 128 | 333
gastric carcinoma 127 | 807
Prostatic Neoplasms 126 | 495
Waldenstrons macroglobulinemia 125 | 765
Asthma 123 | 385
Kidney disease 120 | 430
medulloblastoma 119 | 720
Short stature 118 | 531
esophageal adenocarcinoma 118 | 737
Hypertensive disease 116 | 292
Dull intelligence 115 | 645
Low intelligence 115 | 645
Mental Retardation 115 | 645
Mental deficiency 115 | 645
Multiple Sclerosis 115 | 540
Poor school performance 115 | 645
active Crohn's disease 115 | 922
Major Depressive Disorder 114 | 301
non primary Sjogren syndrome sicca 114 | 891
Parkinson's disease 113 | 392
Osteoporosis 111 | 363
autosomal dominant Emery-Dreifuss muscular dystrophy 111 | 510
Liver cancer 110 | 604
Alcoholic Intoxication, Chronic 108 | 289
acute myeloid leukemia 108 | 783
active ulcerative colitis 106 | 764
fibroadenoma 106 | 559
Duchenne muscular dystrophy 103 | 601
Down syndrome 102 | 499
Vascular disease 100 | 319
aldosterone-producing adenoma 99 | 665

Tissue

Endocrine System 2,301 | 18,159
Female tissues 2,174 | 17,400
Digestive Tract 2,167 | 17,369
Male tissues 2,147 | 17,142
Skin and soft tissues 2,137 | 17,230
Nervous System 2,131 | 16,725
Blood and immune system 2,128 | 16,909
Urinary Tract 2,097 | 16,678
Liver and Pancreas 2,092 | 16,750
Respiratory system 2,056 | 16,393
Cardiovascular System 1,925 | 15,192

Target Family

Non-IDG 1,078 | 12,091
Enzyme 480 | 4,145
oGPCR 415 | 421
GPCR 304 | 408
Kinase 204 | 634
Transcription Factor 97 | 1,400
Epigenetic 39 | 242
Nuclear Receptor 16 | 48
Ion Channel 15 | 344
Transporter 7 | 473
TF/Epigenetic 2 | 38

Reactome Pathway

Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Tyrosine-protein phosphatase non-receptor type 18 PTPN18 Tbio Enzyme -0.77241 5.46 77
Heterogeneous nuclear ribonucleoprotein M HNRNPM Tbio Non-IDG -1.64443 45.9 331
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Olfactory receptor 51B2 OR51B2 Tdark oGPCR 0.12 0.65 26
Olfactory receptor 51B4 OR51B4 Tdark oGPCR 0.05 1.19 4