Development Level

Tbio 1,250 | 10,625
Tchem 528 | 1,890
Tdark 515 | 7,003
Tclin 222 | 602

Collection

GPCR: IDG Consortium (Targets) 64 | 127
Kinase: IDG Consortium (Targets) 14 | 125
GPCR: IDG Consortium (Complete/Control) 13 | 26
Kinase: IDG Consortium (Complete/Control) 5 | 37

IMPC Phenotype

preweaning lethality, complete... 102 | 633
decreased lean body mass 43 | 195
preweaning lethality, incomple... 42 | 260
decreased bone mineral content 36 | 157
decreased body weight 34 | 174
embryonic lethality prior to t... 33 | 187
abnormal behavior 29 | 226
decreased total body fat amoun... 28 | 186
abnormal bone structure 25 | 131
abnormal embryo size 24 | 112
enlarged heart 21 | 111
abnormal retina morphology 20 | 100
decreased grip strength 20 | 123
increased circulating alkaline... 20 | 119
decreased bone mineral density 19 | 126
decreased circulating glucose ... 17 | 121
hypoactivity 17 | 89
decreased mean corpuscular vol... 16 | 50
embryonic lethality prior to o... 16 | 148
increased or absent threshold ... 16 | 128
decreased body length 14 | 108
decreased circulating choleste... 14 | 85
decreased circulating triglyce... 14 | 83
increased mean corpuscular hem... 14 | 93
increased mean corpuscular vol... 14 | 91
abnormal bone mineralization 13 | 55
abnormal retinal pigmentation 13 | 61
decreased circulating HDL chol... 13 | 77
decreased circulating serum al... 13 | 79
increased circulating HDL chol... 13 | 63
decreased circulating insulin ... 12 | 75
decreased fasted circulating g... 12 | 49
decreased prepulse inhibition 12 | 52
improved glucose tolerance 12 | 56
increased blood urea nitrogen ... 12 | 44
increased grip strength 12 | 83
increased total body fat amoun... 12 | 57
short tibia 12 | 82
abnormal lens morphology 11 | 73
decreased circulating fructosa... 11 | 31
hyperactivity 11 | 108
impaired glucose tolerance 11 | 52
increased bone mineral content 11 | 92
increased lean body mass 11 | 107
decreased hemoglobin content 10 | 53
decreased lumbar vertebrae num... 10 | 62
increased leukocyte cell numbe... 10 | 37
abnormal coat-hair pigmentatio... 9 | 54
abnormal sleep behavior 9 | 63
decreased caudal vertebrae num... 9 | 49
decreased circulating alanine ... 9 | 53
decreased mean corpuscular hem... 9 | 34
decreased startle reflex 9 | 48
increased circulating calcium ... 9 | 32
male infertility 9 | 62
small testis 9 | 37
tremors 9 | 34
abnormal heart morphology 8 | 51
abnormal neural tube closure 8 | 37
abnormal testis morphology 8 | 30
decreased circulating amylase ... 8 | 24
decreased circulating total pr... 8 | 41
increased body weight 8 | 42
increased fasted circulating g... 8 | 68
increased hemoglobin content 8 | 45
thrombocytopenia 8 | 46
decreased circulating LDL chol... 7 | 37
decreased circulating iron lev... 7 | 25
decreased heart weight 7 | 44
decreased leukocyte cell numbe... 7 | 54
impaired righting response 7 | 19
increased circulating LDL chol... 7 | 15
increased circulating choleste... 7 | 53
increased circulating phosphat... 7 | 24
increased circulating sodium l... 7 | 71
increased heart weight 7 | 37
increased sacral vertebrae num... 7 | 62
persistence of hyaloid vascula... 7 | 22
prenatal lethality prior to he... 7 | 64
abnormal behavioral response t... 6 | 52
abnormal cornea morphology 6 | 24
abnormal epididymis morphology 6 | 31
abnormal kidney morphology 6 | 30
abnormal rib morphology 6 | 28
abnormal seminal vesicle morph... 6 | 47
cardiovascular system phenotyp... 6 | 35
decreased T cell number 6 | 31
decreased blood urea nitrogen ... 6 | 31
decreased circulating calcium ... 6 | 33
decreased circulating chloride... 6 | 32
decreased circulating creatini... 6 | 31
decreased circulating sodium l... 6 | 18
decreased hematocrit 6 | 25
decreased rib number 6 | 59
enlarged epididymis 6 | 27
increased body length 6 | 20
increased circulating iron lev... 6 | 25
increased circulating potassiu... 6 | 31
limb grasping 6 | 35
vertebral fusion 6 | 23

Disease

ovarian cancer 1,080 | 8,491
osteosarcoma 1,025 | 7,933
psoriasis 956 | 6,685
medulloblastoma, large-cell 857 | 6,234
glioblastoma 831 | 5,572
lung cancer 663 | 4,473
Cancer 634 | 2,346
atypical teratoid / rhabdoid tumor 631 | 4,369
Breast cancer 488 | 3,098
pilocytic astrocytoma 488 | 3,086
invasive ductal carcinoma 484 | 2,950
malignant mesothelioma 484 | 3,163
primitive neuroectodermal tumor 470 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 453 | 3,289
pediatric high grade glioma 445 | 2,712
lung carcinoma 438 | 2,844
lung adenocarcinoma 437 | 2,714
non-small cell lung cancer 434 | 2,798
oligodendroglioma 433 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 425 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 398 | 2,956
interstitial cystitis 387 | 2,299
Carcinoma 385 | 2,147
ependymoma 384 | 2,514
subependymal giant cell astrocytoma 347 | 2,287
pancreatic cancer 345 | 2,300
ulcerative colitis 345 | 2,087
diabetes mellitus 337 | 1,663
astrocytic glioma 305 | 2,241
pituitary cancer 298 | 1,972
ductal carcinoma in situ 295 | 1,745
adult high grade glioma 288 | 2,148
breast carcinoma 285 | 1,614
group 4 medulloblastoma 277 | 1,875
Pick disease 275 | 1,893
astrocytoma 272 | 1,493
group 3 medulloblastoma 268 | 2,254
cystic fibrosis 266 | 1,670
colon cancer 251 | 1,475
tuberculosis 229 | 1,563
posterior fossa group A ependymoma 227 | 1,511
medulloblastoma 226 | 1,524
adrenocortical carcinoma 208 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 208 | 1,795
sonic hedgehog group medulloblastoma 207 | 1,482
Multiple myeloma 198 | 1,327
primary pancreatic ductal adenocarcinoma 195 | 1,271
Rheumatoid Arthritis 194 | 1,170
Obesity 182 | 616
juvenile dermatomyositis 177 | 1,189
posterior fossa group B ependymoma 174 | 1,530
cutaneous lupus erythematosus 169 | 1,056
acute quadriplegic myopathy 163 | 1,157
atypical teratoid/rhabdoid tumor 159 | 1,095
dermatomyositis 153 | 966
Schizophrenia 145 | 503
spina bifida 143 | 1,064
Atopic dermatitis 141 | 944
primary Sjogren syndrome 140 | 788
Alzheimer's disease 136 | 644
Mammary Neoplasms 136 | 410
nasopharyngeal carcinoma 133 | 1,056
gastric carcinoma 131 | 832
Endometriosis 117 | 535
active Crohn's disease 113 | 918
esophageal adenocarcinoma 113 | 737
Waldenstrons macroglobulinemia 112 | 764
Kidney disease 111 | 397
Asthma 109 | 349
Prostatic Neoplasms 108 | 471
Parkinson's disease 105 | 364
Multiple Sclerosis 102 | 498
Duchenne muscular dystrophy 100 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 100 | 499
fibroadenoma 98 | 557
acute myeloid leukemia 95 | 785
non-small cell lung carcinoma 95 | 413
Hypertension 94 | 293
pancreatic carcinoma 93 | 567
non primary Sjogren syndrome sicca 92 | 840
Down syndrome 91 | 548
Vascular disease 88 | 281
aldosterone-producing adenoma 87 | 664
hepatocellular carcinoma 87 | 550
Atherosclerosis 84 | 275
Intellectual disability 84 | 573
IGA Glomerulonephritis 79 | 454
mucosa-associated lymphoid tissue lymphoma 79 | 480
Cerebrovascular disease 78 | 231
Hypertensive disease 78 | 193
progressive supranuclear palsy 78 | 674
tuberculosis and treatment for 6 months 78 | 686
Polycystic Ovary Syndrome 77 | 334
Amyotrophic Lateral Sclerosis 76 | 432
Heart disease 75 | 279
Osteoporosis 74 | 259
Stomach Neoplasms 73 | 282
Bipolar Disorder 72 | 266
Autistic Disorder 70 | 320
Coronary artery disease 70 | 240

Tissue

Female tissues 2,389 | 18,646
Urinary Tract 2,355 | 18,443
Nervous System 2,312 | 18,560
Endocrine System 2,302 | 18,511
Digestive Tract 2,278 | 18,472
Skin and soft tissues 2,216 | 18,114
Liver and Pancreas 2,168 | 18,135
Blood and immune system 2,142 | 17,994
Cardiovascular System 2,133 | 17,957
Male tissues 2,099 | 17,968
Respiratory system 2,056 | 17,483

Target Family

Non-IDG 1,010 | 11,969
Enzyme 459 | 4,146
oGPCR 416 | 421
GPCR 303 | 408
Kinase 200 | 634
Transcription Factor 67 | 1,400
Epigenetic 26 | 242
Ion Channel 15 | 341
Nuclear Receptor 12 | 48
Transporter 6 | 473
TF/Epigenetic 1 | 38

Reactome Pathway

Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
Somatostatin receptor type 1 SSTR1 Tclin GPCR -2.13194 126.3 290
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
Somatostatin receptor type 2 SSTR2 Tclin GPCR -2.51625 341.8 227
Tyrosine-protein kinase Fer FER Tchem Kinase -1.84299 53.1 358
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
High affinity nerve growth factor receptor NTRK1 Tchem Kinase -3.03552 1003.4 1000