Development Level

Tbio 1,250 | 10,625
Tchem 529 | 1,890
Tdark 515 | 7,003
Tclin 222 | 602

Collection

Eligible non-olfactory GPCR Proteins 68 | 143
Eligible Kinase Proteins 16 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 102 | 633
decreased lean body mass 43 | 195
preweaning lethality, incomple... 42 | 260
decreased bone mineral content 36 | 157
decreased body weight 34 | 174
embryonic lethality prior to t... 33 | 187
abnormal behavior 29 | 226
decreased total body fat amoun... 28 | 186
abnormal bone structure 25 | 131
abnormal embryo size 24 | 112
enlarged heart 21 | 111
abnormal retina morphology 20 | 100
decreased grip strength 20 | 123
increased circulating alkaline... 20 | 119
decreased bone mineral density 19 | 126
decreased circulating glucose ... 17 | 121
hypoactivity 17 | 89
decreased mean corpuscular vol... 16 | 50
embryonic lethality prior to o... 16 | 148
increased or absent threshold ... 16 | 128
decreased body length 14 | 108
decreased circulating choleste... 14 | 85
decreased circulating triglyce... 14 | 83
increased mean corpuscular hem... 14 | 93
increased mean corpuscular vol... 14 | 91
abnormal bone mineralization 13 | 55
abnormal retinal pigmentation 13 | 61
decreased circulating HDL chol... 13 | 77
decreased circulating serum al... 13 | 79
increased circulating HDL chol... 13 | 63
decreased circulating insulin ... 12 | 75
decreased fasted circulating g... 12 | 49
decreased prepulse inhibition 12 | 52
improved glucose tolerance 12 | 56
increased blood urea nitrogen ... 12 | 44
increased grip strength 12 | 83
increased total body fat amoun... 12 | 57
short tibia 12 | 82
abnormal lens morphology 11 | 73
decreased circulating fructosa... 11 | 31
hyperactivity 11 | 108
impaired glucose tolerance 11 | 52
increased bone mineral content 11 | 92
increased lean body mass 11 | 107
decreased hemoglobin content 10 | 53
decreased lumbar vertebrae num... 10 | 62
increased leukocyte cell numbe... 10 | 37
abnormal coat/hair pigmentatio... 9 | 54
abnormal sleep behavior 9 | 63
decreased caudal vertebrae num... 9 | 49
decreased circulating alanine ... 9 | 53
decreased mean corpuscular hem... 9 | 34
decreased startle reflex 9 | 48
increased circulating calcium ... 9 | 32
male infertility 9 | 62
small testis 9 | 37
tremors 9 | 34
abnormal heart morphology 8 | 51
abnormal neural tube closure 8 | 37
abnormal testis morphology 8 | 30
decreased circulating amylase ... 8 | 24
decreased circulating total pr... 8 | 41
increased body weight 8 | 42
increased fasted circulating g... 8 | 68
increased hemoglobin content 8 | 45
thrombocytopenia 8 | 46
decreased circulating LDL chol... 7 | 37
decreased circulating iron lev... 7 | 25
decreased heart weight 7 | 44
decreased leukocyte cell numbe... 7 | 54
impaired righting response 7 | 19
increased circulating LDL chol... 7 | 15
increased circulating choleste... 7 | 53
increased circulating phosphat... 7 | 24
increased circulating sodium l... 7 | 71
increased heart weight 7 | 37
increased sacral vertebrae num... 7 | 62
persistence of hyaloid vascula... 7 | 22
prenatal lethality prior to he... 7 | 64
abnormal behavioral response t... 6 | 52
abnormal cornea morphology 6 | 24
abnormal epididymis morphology 6 | 31
abnormal kidney morphology 6 | 30
abnormal rib morphology 6 | 28
abnormal seminal vesicle morph... 6 | 47
cardiovascular system phenotyp... 6 | 35
decreased T cell number 6 | 31
decreased blood urea nitrogen ... 6 | 31
decreased circulating calcium ... 6 | 33
decreased circulating chloride... 6 | 32
decreased circulating creatini... 6 | 31
decreased circulating sodium l... 6 | 18
decreased hematocrit 6 | 25
decreased rib number 6 | 59
enlarged epididymis 6 | 27
increased body length 6 | 20
increased circulating iron lev... 6 | 25
increased circulating potassiu... 6 | 31
limb grasping 6 | 35
vertebral fusion 6 | 23

Disease

ovarian cancer 1,079 | 8,484
osteosarcoma 1,025 | 7,933
psoriasis 956 | 6,685
medulloblastoma, large-cell 857 | 6,234
glioblastoma 831 | 5,572
lung cancer 662 | 4,466
Cancer 634 | 2,346
atypical teratoid / rhabdoid tumor 631 | 4,369
Breast cancer 488 | 3,094
pilocytic astrocytoma 488 | 3,086
invasive ductal carcinoma 484 | 2,950
malignant mesothelioma 484 | 3,162
primitive neuroectodermal tumor 470 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 453 | 3,289
pediatric high grade glioma 445 | 2,712
lung carcinoma 438 | 2,844
lung adenocarcinoma 437 | 2,713
non-small cell lung cancer 434 | 2,798
oligodendroglioma 433 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 425 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 398 | 2,956
interstitial cystitis 387 | 2,299
Carcinoma 385 | 2,147
ependymoma 384 | 2,514
subependymal giant cell astrocytoma 347 | 2,287
pancreatic cancer 345 | 2,300
ulcerative colitis 345 | 2,087
diabetes mellitus 337 | 1,663
astrocytic glioma 305 | 2,241
pituitary cancer 298 | 1,972
ductal carcinoma in situ 295 | 1,745
adult high grade glioma 288 | 2,148
breast carcinoma 285 | 1,614
group 4 medulloblastoma 277 | 1,875
Pick disease 275 | 1,893
astrocytoma 272 | 1,493
group 3 medulloblastoma 268 | 2,254
cystic fibrosis 265 | 1,665
colon cancer 251 | 1,475
tuberculosis 229 | 1,557
posterior fossa group A ependymoma 227 | 1,511
medulloblastoma 226 | 1,524
adrenocortical carcinoma 208 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 208 | 1,795
sonic hedgehog group medulloblastoma 207 | 1,482
Multiple myeloma 199 | 1,327
Rheumatoid Arthritis 195 | 1,160
primary pancreatic ductal adenocarcinoma 195 | 1,271
Obesity 182 | 616
juvenile dermatomyositis 177 | 1,189
posterior fossa group B ependymoma 174 | 1,530
cutaneous lupus erythematosus 169 | 1,056
acute quadriplegic myopathy 163 | 1,157
atypical teratoid/rhabdoid tumor 159 | 1,095
dermatomyositis 154 | 933
Schizophrenia 145 | 501
spina bifida 143 | 1,064
Atopic dermatitis 141 | 944
primary Sjogren syndrome 141 | 789
Alzheimer's disease 136 | 644
Mammary Neoplasms 136 | 410
nasopharyngeal carcinoma 133 | 1,056
gastric carcinoma 131 | 832
Endometriosis 117 | 535
Waldenstrons macroglobulinemia 113 | 765
active Crohn's disease 113 | 918
esophageal adenocarcinoma 113 | 737
Kidney disease 111 | 396
Asthma 109 | 349
Prostatic Neoplasms 108 | 471
Parkinson's disease 105 | 364
Multiple Sclerosis 102 | 498
Duchenne muscular dystrophy 100 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 100 | 499
fibroadenoma 98 | 557
non-small cell lung carcinoma 95 | 413
acute myeloid leukemia 94 | 780
Hypertension 93 | 287
pancreatic carcinoma 93 | 567
non primary Sjogren syndrome sicca 92 | 840
Down syndrome 91 | 548
Vascular disease 88 | 281
aldosterone-producing adenoma 87 | 664
Atherosclerosis 84 | 275
Intellectual disability 84 | 573
IGA Glomerulonephritis 79 | 454
mucosa-associated lymphoid tissue lymphoma 79 | 480
Cerebrovascular disease 78 | 231
Hypertensive disease 78 | 193
hepatocellular carcinoma 78 | 532
progressive supranuclear palsy 78 | 674
tuberculosis and treatment for 6 months 78 | 686
Amyotrophic Lateral Sclerosis 76 | 431
Heart disease 75 | 279
Polycystic Ovary Syndrome 75 | 332
Osteoporosis 73 | 257
Stomach Neoplasms 73 | 282
Bipolar Disorder 72 | 266
Autistic Disorder 70 | 320
Coronary artery disease 70 | 240

Tissue

Female tissues 2,390 | 18,647
Urinary Tract 2,356 | 18,444
Nervous System 2,313 | 18,561
Endocrine System 2,303 | 18,512
Digestive Tract 2,279 | 18,473
Skin and soft tissues 2,217 | 18,115
Liver and Pancreas 2,169 | 18,136
Blood and immune system 2,143 | 17,995
Cardiovascular System 2,134 | 17,958
Male tissues 2,100 | 17,969
Respiratory system 2,057 | 17,484

Target Family

Non-IDG 1,010 | 11,971
Enzyme 460 | 4,146
oGPCR 416 | 421
GPCR 303 | 406
Kinase 200 | 634
Transcription Factor 67 | 1,400
Epigenetic 26 | 242
Ion Channel 15 | 341
Nuclear Receptor 12 | 48
Transporter 6 | 473
TF/Epigenetic 1 | 38

Reactome Pathway

Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Taste receptor type 1 member 3 TAS1R3 Tbio GPCR -2.19758 165.4 232
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165
VPS10 domain-containing receptor SorCS3 SORCS3 Tbio Non-IDG -0.54622 5.51 46
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729