Development Level

Tclin 2 | 612
Tbio 1 | 11,651
Tchem 1 | 1,388

Disease

Bipolar Disorder 4 | 666
Carcinoma 3 | 11,493
Depressive disorder 3 | 409
Major Depressive Disorder 3 | 301
Mental Depression 3 | 333
Schizophrenia 3 | 1,160
Unipolar Depression 3 | 250
Alcohol dependence 2 | 107
Attention deficit hyperactivity disorder 2 | 278
Autistic Disorder 2 | 364
Autoimmune polyendocrine syndrome 2 | 6
Constipation 2 | 181
Diarrhea 2 | 253
Mood Disorders 2 | 184
Paranoid Schizophrenia 2 | 18
Psychotic Disorders 2 | 151
Sudden infant death syndrome 2 | 32
lung carcinoma 2 | 2,843
medulloblastoma, large-cell 2 | 6,241
psoriasis 2 | 6,694
ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 1 | 1
Abnormality of the face 1 | 10
Alcohol abuse 1 | 50
Alcoholic Intoxication, Chronic 1 | 289
Anxiety disorder 1 | 23
Aromatic amino acid decarboxylase deficiency 1 | 1
Attention Deficit Disorder with Hyperactivity 1 | 21
Axial hypotonia 1 | 46
Babinski Reflex 1 | 100
Blepharoptosis 1 | 231
Chordoid glioma 1 | 4
Choreoathetoid movements 1 | 32
Choreoathetosis 1 | 32
Cocaine Dependence 1 | 51
Congenital anomaly of face 1 | 56
Decreased CSF homovanillic acid 1 | 3
Deficiency of aromatic-L-amino-acid decarboxylase 1 | 1
Depression, Bipolar 1 | 12
Depressive Disorder, Major 1 | 19
Disorder of face 1 | 10
Drug-induced depressive state 1 | 14
Dyschezia 1 | 135
Dystonia 1 | 164
Dystonia, Limb 1 | 9
Fever 1 | 138
Gastroesophageal reflux disease 1 | 110
Heartburn 1 | 78
Hepatolenticular Degeneration 1 | 24
Hyperhidrosis disorder 1 | 81
Hyperprolactinemia 1 | 27
Hyperreflexia 1 | 209
Hypertension, Pulmonary 1 | 37
Hypotension 1 | 82
Idiopathic scoliosis 1 | 31
Increased sweating 1 | 81
Infantile onset 1 | 238
Intermittent hypothermia 1 | 2
Irritable bowel syndrome 1 | 60
Irritation - emotion 1 | 68
Kidney Neoplasms 1 | 37
Kidney cancer 1 | 2,613
Limb hypertonia 1 | 5
Liver Cirrhosis, Experimental 1 | 769
Lymphoid leukemia 1 | 160
MAJOR AFFECTIVE DISORDER 2 1 | 22
Malaria 1 | 160
Mental disorders 1 | 12
Miosis disorder 1 | 6
Mood swings 1 | 77
Myoclonus 1 | 74
Nerve Degeneration 1 | 121
Oppositional defiant disorder 1 | 17
Panic disorder 1 | 61
Parkinson Disease 1 | 64
Parkinson's disease 1 | 392
Parkinsonian Disorders 1 | 56
Parkinsonism 1 | 18
Personality disorder 1 | 25
Pheochromocytoma 1 | 24
Pineal gland cancer 1 | 2
Postencephalitic parkinsonism 1 | 12
Ptosis 1 | 48
Pulmonary hypertension 1 | 86
Seasonal affective disorder 1 | 28
Severe major depression with psychotic features 1 | 9
Single major depressive episode 1 | 8
Sleep disturbances 1 | 37
Substance Use Disorders 1 | 1
Substance abuse 1 | 59
Sweating 1 | 81
alcohol use disorder 1 | 12
aldosterone-producing adenoma 1 | 665
colon cancer 1 | 1,478
cutaneous lupus erythematosus 1 | 1,057
esophageal adenocarcinoma 1 | 737
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
nephrosclerosis 1 | 333
osteosarcoma 1 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
ulcerative colitis 1 | 1,819

Tissue

Endocrine System 4 | 18,159
Nervous System 4 | 16,725
Blood and immune system 3 | 16,909
Digestive Tract 3 | 17,369
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Cardiovascular System 2 | 15,192
Urinary Tract 2 | 16,678

Target Family

Enzyme 4 | 4,145

Reactome Pathway

Serotonin and melatonin biosyn... 4 | 4
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tryptophan 5-hydroxylase 2 TPH2 Tchem Enzyme -2.44646 308.6 361
Tryptophan 5-hydroxylase 1 TPH1 Tclin Enzyme -2.93036 772.3 415
Acetylserotonin O-methyltransferase ASMT Tbio Enzyme -2.40166 255.0 111
Aromatic-L-amino-acid decarboxylase DDC Tclin Enzyme -2.78263 593.3 412