Development Level

Tbio 141 | 11,445
Tchem 12 | 1,598
Tdark 11 | 6,588
Tclin 6 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 28 | 979
embryonic lethality prior to o... 7 | 239
embryonic growth retardation 6 | 106
embryonic lethality prior to t... 6 | 278
abnormal embryo size 5 | 220
decreased circulating choleste... 4 | 93
preweaning lethality, incomple... 4 | 499
increased circulating HDL chol... 3 | 80
increased fasted circulating g... 3 | 76
abnormal behavior 2 | 298
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal craniofacial morpholo... 2 | 33
abnormal heart morphology 2 | 162
abnormal placenta morphology 2 | 5
abnormal placenta size 2 | 20
abnormal seminal vesicle morph... 2 | 114
abnormal skin coloration 2 | 25
abnormal tail morphology 2 | 25
anophthalmia 2 | 33
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased heart left ventricle... 2 | 28
decreased mean corpuscular hem... 2 | 31
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
edema 2 | 59
impaired glucose tolerance 2 | 75
increased circulating chloride... 2 | 41
increased hematocrit 2 | 46
increased mean corpuscular vol... 2 | 92
microphthalmia 2 | 26
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small testis 2 | 58
syndactyly 2 | 23
abnormal forebrain morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal midbrain morphology 1 | 10
abnormal motor learning 1 | 3
abnormal neural tube closure 1 | 46
abnormal placenta vasculature 1 | 2
abnormal testis morphology 1 | 43
brachydactyly 1 | 19
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased heart weight 1 | 62
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
long tibia 1 | 25
male infertility 1 | 123
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small kidney 1 | 16
small spleen 1 | 19

Disease

ovarian cancer 114 | 8,520
Carcinoma 95 | 11,493
glioblastoma 83 | 5,792
lung cancer 82 | 4,740
medulloblastoma, large-cell 79 | 6,241
psoriasis 79 | 6,694
osteosarcoma 76 | 7,950
atypical teratoid / rhabdoid tumor 68 | 5,112
group 3 medulloblastoma 68 | 4,104
Breast cancer 60 | 3,578
primitive neuroectodermal tumor 54 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 51 | 3,291
non-small cell lung cancer 50 | 2,890
ependymoma 47 | 4,679
adult high grade glioma 46 | 3,801
malignant mesothelioma 46 | 3,232
Multiple myeloma 43 | 1,332
adrenocortical carcinoma 43 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,989
invasive ductal carcinoma 42 | 2,951
lung adenocarcinoma 36 | 2,716
Cancer 29 | 2,499
Kidney cancer 28 | 2,613
oligodendroglioma 28 | 2,850
Waldenstrons macroglobulinemia 26 | 765
breast carcinoma 26 | 1,638
pancreatic cancer 26 | 2,398
colon cancer 25 | 1,478
ductal carcinoma in situ 25 | 1,745
dermatomyositis 24 | 966
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,962
Atopic dermatitis 22 | 952
Endometriosis 22 | 540
Pick disease 20 | 1,894
astrocytic glioma 20 | 2,597
nasopharyngeal carcinoma 19 | 1,058
Astrocytoma, Pilocytic 17 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
Intellectual disability 16 | 1,016
subependymal giant cell astrocytoma 16 | 2,287
HIV Infections 15 | 102
acute quadriplegic myopathy 15 | 1,158
astrocytoma 14 | 1,146
Rheumatoid arthritis 12 | 1,191
juvenile dermatomyositis 12 | 1,187
pediatric high grade glioma 12 | 1,064
primary Sjogren syndrome 12 | 735
tuberculosis 12 | 2,010
ulcerative colitis 12 | 1,819
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Small head 11 | 374
active Crohn's disease 11 | 922
non primary Sjogren syndrome sicca 11 | 891
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
diabetes mellitus 10 | 1,728
group 4 medulloblastoma 10 | 1,855
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
acute myeloid leukemia 9 | 783
interstitial cystitis 9 | 2,312
lung carcinoma 9 | 2,843
pituitary cancer 9 | 1,972
Epilepsy 8 | 792
Seizures 8 | 596
Short stature 8 | 531
Microcephaly 7 | 166
gastric carcinoma 7 | 807
Acquired metabolic disease 6 | 336
Alzheimer's disease 6 | 658
Anteverted nostril 6 | 191
Autosomal recessive predisposition 6 | 1,442
Cornelia de Lange syndrome 6 | 21
Dilated ventricles (finding) 6 | 121
Downward slant of palpebral fissure 6 | 158
Lissencephaly 6 | 69
Osteoporosis 6 | 363
Roberts syndrome 6 | 15
aldosterone-producing adenoma 6 | 665
esophageal adenocarcinoma 6 | 737
hereditary spastic paraplegia 6 | 318
posterior fossa group A ependymoma 6 | 468
progressive supranuclear palsy 6 | 676
Cerebellar Hypoplasia 5 | 61
Fetal Growth Retardation 5 | 189
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Orbital separation excessive 5 | 244
Schizophrenia 5 | 1,160
Short neck 5 | 140
Short nose 5 | 132
Small nose 5 | 132
cutaneous lupus erythematosus 5 | 1,057
hepatocellular carcinoma 5 | 547

Tissue

Endocrine System 169 | 18,159
Blood and immune system 167 | 16,909
Digestive Tract 167 | 17,369
Female tissues 167 | 17,400
Male tissues 167 | 17,142
Nervous System 167 | 16,725
Respiratory system 167 | 16,393
Urinary Tract 167 | 16,678
Liver and Pancreas 166 | 16,750
Skin and soft tissues 166 | 17,230
Cardiovascular System 162 | 15,192

Target Family

Non-IDG 100 | 12,091
Enzyme 64 | 4,145
Kinase 5 | 634
Epigenetic 1 | 242

Reactome Pathway

Separation of Sister Chromatid... 170 | 170
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Centromere protein K CENPK Tbio Non-IDG -1.21832 16.6 130
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Kinesin-like protein KIF2C KIF2C Tbio Non-IDG -2.12404 136.3 256
Spindle and kinetochore-associated protein 2 SKA2 Tbio Non-IDG -1.23206 10.2 108
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169