Development Level

Tbio 42 | 10,625
Tchem 17 | 1,890
Tdark 14 | 7,003
Tclin 3 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal embryo size 4 | 112
embryonic growth retardation 3 | 28
abnormal lens morphology 2 | 73
anophthalmia 2 | 20
cataract 2 | 26
increased lean body mass 2 | 107
microphthalmia 2 | 15
abnormal behavior 1 | 226
abnormal cornea morphology 1 | 24
abnormal craniofacial morpholo... 1 | 12
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal forebrain morphology 1 | 4
abnormal head shape 1 | 4
abnormal heart morphology 1 | 51
abnormal hindbrain morphology 1 | 2
abnormal midbrain morphology 1 | 2
abnormal neural tube closure 1 | 37
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal skin coloration 1 | 18
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
corneal opacity 1 | 25
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
edema 1 | 11
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased leukocyte cell numbe... 1 | 37
increased mean platelet volume 1 | 19
increased neutrophil cell numb... 1 | 15
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
pallor 1 | 13
prenatal lethality 1 | 16
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 43 | 8,484
Cancer 36 | 2,346
psoriasis 35 | 6,685
lung cancer 32 | 4,466
glioblastoma 29 | 5,572
osteosarcoma 27 | 7,933
Breast cancer 22 | 3,094
medulloblastoma, large-cell 21 | 6,234
atypical teratoid / rhabdoid tumor 19 | 4,369
lung adenocarcinoma 18 | 2,713
malignant mesothelioma 18 | 3,162
invasive ductal carcinoma 17 | 2,950
pancreatic cancer 17 | 2,300
non-small cell lung cancer 16 | 2,798
ductal carcinoma in situ 15 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
ulcerative colitis 15 | 2,087
Multiple myeloma 14 | 1,327
pituitary cancer 14 | 1,972
Mammary Neoplasms 13 | 410
ependymoma 13 | 2,514
lung carcinoma 13 | 2,844
Stomach Neoplasms 12 | 282
breast carcinoma 12 | 1,614
cystic fibrosis 12 | 1,665
diabetes mellitus 12 | 1,663
oligodendroglioma 12 | 2,849
pilocytic astrocytoma 12 | 3,086
astrocytoma 11 | 1,493
colon cancer 11 | 1,475
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
medulloblastoma 11 | 1,524
primitive neuroectodermal tumor 11 | 3,031
group 4 medulloblastoma 10 | 1,875
Brain Ischemia 9 | 87
Liver carcinoma 9 | 217
Lung Neoplasms 9 | 171
non-small cell lung carcinoma 9 | 413
primary pancreatic ductal adenocarcinoma 9 | 1,271
tuberculosis 9 | 1,557
Arthritis 8 | 248
Endometriosis 8 | 535
Reperfusion Injury 8 | 84
Rheumatoid Arthritis 8 | 1,160
Vascular disease 8 | 281
acute myeloid leukemia 8 | 780
adrenocortical carcinoma 8 | 1,427
adult high grade glioma 8 | 2,148
astrocytic glioma 8 | 2,241
cutaneous lupus erythematosus 8 | 1,056
Kidney disease 7 | 396
Obesity 7 | 616
Prostatic Neoplasms 7 | 471
Waldenstrons macroglobulinemia 7 | 765
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
posterior fossa group A ependymoma 7 | 1,511
Alzheimer's disease 6 | 644
Eye disease 6 | 55
Heat Stroke 6 | 12
Hyperalgesia 6 | 71
Neoplasm Invasiveness 6 | 127
Neoplasm Metastasis 6 | 138
acute quadriplegic myopathy 6 | 1,157
nasopharyngeal carcinoma 6 | 1,056
ovarian neoplasm 6 | 97
pediatric high grade glioma 6 | 2,712
sonic hedgehog group medulloblastoma 6 | 1,482
Asthma 5 | 349
Carcinoma 5 | 2,147
Cardiomyopathies 5 | 90
Colonic Neoplasms 5 | 126
Heart disease 5 | 279
Inflammatory bowel disease 5 | 142
Juvenile arthritis 5 | 124
Multiple Sclerosis 5 | 498
Neoplastic Cell Transformation 5 | 81
Squamous cell carcinoma 5 | 94
active Crohn's disease 5 | 918
gastric cancer 5 | 430
hepatocellular carcinoma 5 | 532
inflammatory breast cancer 5 | 404
juvenile dermatomyositis 5 | 1,189
non primary Sjogren syndrome sicca 5 | 840
subependymal giant cell astrocytoma 5 | 2,287
Adenoma 4 | 165
Amyotrophic Lateral Sclerosis 4 | 431
Atherosclerosis 4 | 275
Atopic dermatitis 4 | 944
Dermatitis 4 | 107
Down syndrome 4 | 548
Hypersensitivity reaction type II disease 4 | 235
Lung disease 4 | 132
Peripheral Neuropathy 4 | 303
Pick disease 4 | 1,893
Schizophrenia 4 | 501
chronic lymphosyte leukemia 4 | 232
dermatomyositis 4 | 933
esophageal adenocarcinoma 4 | 737
periodontitis 4 | 269

Tissue

Endocrine System 75 | 18,512
Female tissues 75 | 18,647
Male tissues 75 | 17,969
Blood and immune system 74 | 17,995
Cardiovascular System 74 | 17,958
Digestive Tract 74 | 18,473
Nervous System 74 | 18,561
Urinary Tract 74 | 18,444
Liver and Pancreas 73 | 18,136
Respiratory system 73 | 17,484
Skin and soft tissues 67 | 18,115

Target Family

Non-IDG 43 | 11,971
Enzyme 16 | 4,146
Kinase 9 | 634
Transcription Factor 6 | 1,400
Epigenetic 2 | 242

Reactome Pathway

Senescence-Associated Secretor... 76 | 76
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Ubiquitin-conjugating enzyme E2 E1 UBE2E1 Tbio Non-IDG -1.18305 12.0 72
Anaphase-promoting complex subunit 15 ANAPC15 Tdark Enzyme -0.41378 2.22 21
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43357 2997.4 1177
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Anaphase-promoting complex subunit CDC26 CDC26 Tbio Enzyme -0.67669 4.56 45
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.46968 311.2 390
Fizzy-related protein homolog FZR1 Tbio Non-IDG -1.74457 58.7 182