Development Level

Tbio 46 | 11,651
Tchem 15 | 1,388
Tdark 11 | 6,593
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal embryo size 5 | 220
abnormal heart morphology 3 | 162
embryonic growth retardation 3 | 106
embryonic lethality prior to t... 3 | 278
abnormal lens morphology 2 | 81
abnormal placenta size 2 | 20
anophthalmia 2 | 33
cataract 2 | 92
decreased mean corpuscular hem... 2 | 31
edema 2 | 59
enlarged heart 2 | 210
microphthalmia 2 | 26
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal forebrain morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal joint morphology 1 | 23
abnormal lung morphology 1 | 26
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal placenta morphology 1 | 5
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
brachydactyly 1 | 19
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased red blood cell distr... 1 | 41
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
irregularly shaped pupil 1 | 7
male infertility 1 | 123
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23

Disease

ovarian cancer 44 | 8,519
Cancer 36 | 2,499
psoriasis 35 | 6,694
Carcinoma 33 | 11,493
lung cancer 32 | 4,740
glioblastoma 28 | 5,792
Breast cancer 27 | 3,577
osteosarcoma 27 | 7,950
atypical teratoid / rhabdoid tumor 22 | 5,112
medulloblastoma, large-cell 21 | 6,241
malignant mesothelioma 19 | 3,232
lung adenocarcinoma 18 | 2,716
ependymoma 17 | 4,679
invasive ductal carcinoma 17 | 2,950
non-small cell lung cancer 17 | 2,890
pancreatic cancer 17 | 2,398
ductal carcinoma in situ 15 | 1,744
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,290
Multiple myeloma 14 | 1,332
adult high grade glioma 14 | 3,801
group 3 medulloblastoma 14 | 4,104
pituitary cancer 14 | 1,972
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
diabetes mellitus 13 | 1,728
lung carcinoma 13 | 2,843
Astrocytoma, Pilocytic 12 | 3,081
Stomach Neoplasms 12 | 300
breast carcinoma 12 | 1,637
cystic fibrosis 12 | 1,695
oligodendroglioma 12 | 2,850
Schizophrenia 11 | 1,160
astrocytoma 11 | 1,146
colon cancer 11 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,954
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
primitive neuroectodermal tumor 11 | 3,035
tuberculosis 11 | 2,010
ulcerative colitis 11 | 1,819
Carcinoma, Hepatocellular 10 | 228
Liver carcinoma 10 | 240
Brain Ischemia 9 | 110
Lung Neoplasms 9 | 232
astrocytic glioma 9 | 2,597
group 4 medulloblastoma 9 | 1,855
primary pancreatic ductal adenocarcinoma 9 | 1,108
Arthritis 8 | 290
Endometriosis 8 | 540
Kidney disease 8 | 430
Reperfusion Injury 8 | 86
Rheumatoid arthritis 8 | 1,191
Vascular disease 8 | 319
acute myeloid leukemia 8 | 783
adrenocortical carcinoma 8 | 1,428
cutaneous lupus erythematosus 8 | 1,057
non-small cell lung carcinoma 8 | 317
Cell Transformation, Neoplastic 7 | 97
Depressive disorder 7 | 409
Diarrhea 7 | 253
Hyperalgesia 7 | 83
Obesity 7 | 678
Prostatic Neoplasms 7 | 495
Waldenstrons macroglobulinemia 7 | 765
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Alzheimer's disease 6 | 658
Anemia 6 | 365
Asthma 6 | 385
Carcinoma, Squamous Cell 6 | 110
Cholestasis, Extrahepatic 6 | 25
Eye disease 6 | 62
Heat Stroke 6 | 13
Hypercalcemia 6 | 59
Inflammatory bowel disease 6 | 151
Intellectual disability 6 | 1,016
Kidney cancer 6 | 2,613
Melanoma 6 | 711
Mental Depression 6 | 333
Mesothelioma, Malignant 6 | 105
Neoplasm Invasiveness 6 | 161
Neoplasm Metastasis 6 | 168
Neoplastic Cell Transformation 6 | 89
Ovarian Neoplasms 6 | 102
Squamous cell carcinoma 6 | 129
acute quadriplegic myopathy 6 | 1,158
gastric cancer 6 | 459
medulloblastoma 6 | 720
nasopharyngeal carcinoma 6 | 1,058
ovarian neoplasm 6 | 99
Acromegaly 5 | 51
Arthritis, Juvenile 5 | 126
Atherosclerosis 5 | 291
Heart disease 5 | 306
Hypertension 5 | 396
Juvenile arthritis 5 | 126
Multiple Sclerosis 5 | 540
active Crohn's disease 5 | 922
active ulcerative colitis 5 | 764
hepatocellular carcinoma 5 | 547
juvenile dermatomyositis 5 | 1,187
subependymal giant cell astrocytoma 5 | 2,287

Tissue

Endocrine System 74 | 18,159
Blood and immune system 73 | 16,909
Digestive Tract 73 | 17,369
Female tissues 73 | 17,400
Skin and soft tissues 73 | 17,230
Liver and Pancreas 72 | 16,750
Male tissues 72 | 17,142
Nervous System 72 | 16,725
Respiratory system 72 | 16,393
Urinary Tract 72 | 16,678
Cardiovascular System 70 | 15,192

Target Family

Non-IDG 43 | 12,091
Enzyme 15 | 4,145
Kinase 9 | 634
Transcription Factor 6 | 1,400
Epigenetic 2 | 242

Reactome Pathway

Senescence-Associated Secretor... 75 | 75
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075