Development Level

Tbio 41 | 11,445
Tchem 13 | 1,598
Tclin 7 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
edema 3 | 59
preweaning lethality, incomple... 3 | 499
abnormal retina morphology 2 | 71
decreased hematocrit 2 | 46
embryonic growth retardation 2 | 106
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal embryo size 1 | 220
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal sensory capabilities-... 1 | 8
abnormal skin coloration 1 | 25
abnormal snout morphology 1 | 23
cardiovascular system phenotyp... 1 | 36
decreased bone mineral content 1 | 151
decreased circulating triglyce... 1 | 79
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
enlarged heart 1 | 210
enlarged spleen 1 | 41
hemorrhage 1 | 23
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart rate variabili... 1 | 7
increased monocyte cell number 1 | 63
long tibia 1 | 25
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 51 | 11,493
osteosarcoma 45 | 7,950
glioblastoma 38 | 5,792
ovarian cancer 38 | 8,520
medulloblastoma, large-cell 34 | 6,241
lung cancer 33 | 4,740
atypical teratoid / rhabdoid tumor 31 | 5,112
psoriasis 29 | 6,694
Astrocytoma, Pilocytic 27 | 3,081
ependymoma 27 | 4,679
Kidney cancer 26 | 2,613
adult high grade glioma 26 | 3,801
invasive ductal carcinoma 26 | 2,951
Cancer 24 | 2,499
Breast cancer 23 | 3,578
lung carcinoma 22 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
pancreatic cancer 21 | 2,398
malignant mesothelioma 20 | 3,232
non-small cell lung cancer 19 | 2,890
subependymal giant cell astrocytoma 19 | 2,287
group 3 medulloblastoma 17 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
ulcerative colitis 17 | 1,819
group 4 medulloblastoma 16 | 1,855
oligodendroglioma 16 | 2,850
lung adenocarcinoma 15 | 2,716
primary pancreatic ductal adenocarcinoma 15 | 1,109
Schizophrenia 14 | 1,160
primitive neuroectodermal tumor 14 | 3,035
astrocytic glioma 13 | 2,597
colon cancer 13 | 1,478
cystic fibrosis 13 | 1,696
tuberculosis 13 | 2,010
breast carcinoma 12 | 1,638
pituitary cancer 12 | 1,972
astrocytoma 11 | 1,146
diabetes mellitus 11 | 1,728
interstitial cystitis 11 | 2,312
Alzheimer's disease 10 | 658
ductal carcinoma in situ 10 | 1,745
Waldenstrons macroglobulinemia 9 | 765
juvenile dermatomyositis 9 | 1,187
medulloblastoma 8 | 720
Autosomal recessive predisposition 7 | 1,442
Liver Cirrhosis, Experimental 7 | 769
Multiple Sclerosis 7 | 540
Neoplasm Metastasis 7 | 168
Pick disease 7 | 1,894
Atopic dermatitis 6 | 952
Liver cancer 6 | 604
Neoplasm Invasiveness 6 | 161
Prostatic Neoplasms 6 | 495
pediatric high grade glioma 6 | 1,064
Autistic Disorder 5 | 364
Breast Neoplasms 5 | 445
Depressive disorder 5 | 409
Duchenne muscular dystrophy 5 | 601
Heart disease 5 | 306
Hypertension 5 | 396
Multiple myeloma 5 | 1,332
Parkinson's disease 5 | 392
Proteinuria 5 | 144
acute quadriplegic myopathy 5 | 1,158
cutaneous lupus erythematosus 5 | 1,057
dermatomyositis 5 | 966
gastric carcinoma 5 | 807
head and neck cancer 5 | 271
nasopharyngeal carcinoma 5 | 1,058
Chronic Lymphocytic Leukemia 4 | 262
Dementia 4 | 175
Down syndrome 4 | 499
Epilepsy 4 | 792
Gliosis 4 | 56
Kidney disease 4 | 430
Mammary Neoplasms 4 | 425
Mental Depression 4 | 333
Muscle hypotonia 4 | 571
Neurodegenerative disease 4 | 414
Renal Cell Carcinoma 4 | 214
Rheumatoid arthritis 4 | 1,191
Skin cancer 4 | 469
Small head 4 | 374
Stomach Neoplasms 4 | 300
Vascular disease 4 | 319
acute myeloid leukemia 4 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
esophageal adenocarcinoma 4 | 737
non primary Sjogren syndrome sicca 4 | 891
non-small cell lung carcinoma 4 | 317
pancreatic carcinoma 4 | 562
spina bifida 4 | 1,074
Attention deficit hyperactivity disorder 3 | 278
Becker muscular dystrophy 3 | 191
Bipolar Disorder 3 | 666
Endometriosis 3 | 540
adrenocortical carcinoma 3 | 1,428
mucosa-associated lymphoid tissue lymphoma 3 | 484
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962

Tissue

Digestive Tract 62 | 17,369
Endocrine System 62 | 18,159
Female tissues 62 | 17,400
Male tissues 62 | 17,142
Nervous System 62 | 16,725
Skin and soft tissues 62 | 17,230
Blood and immune system 61 | 16,909
Liver and Pancreas 61 | 16,750
Respiratory system 61 | 16,393
Urinary Tract 61 | 16,678
Cardiovascular System 60 | 15,192

Target Family

Non-IDG 34 | 12,091
Enzyme 14 | 4,145
Kinase 14 | 634

Reactome Pathway

Semaphorin interactions 62 | 62
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Semaphorin-5A SEMA5A Tbio Non-IDG -1.82162 69.8 238
Plexin-D1 PLXND1 Tbio Non-IDG -1.64721 46.3 171
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.61227 42.0 183
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Rho guanine nucleotide exchange factor 12 ARHGEF12 Tbio Non-IDG -2.63794 448.3 88
Dihydropyrimidinase-related protein 1 CRMP1 Tbio Enzyme -1.60377 40.8 318
Plexin-C1 PLXNC1 Tbio Non-IDG -1.36131 20.0 88
Rho-related GTP-binding protein Rho6 RND1 Tbio Enzyme -2.08631 119.8 60
Rho-related GTP-binding protein RhoB RHOB Tbio Enzyme -2.41406 272.2 151
Hepatocyte growth factor receptor MET Tclin Kinase -3.32232 2013.7 1982