Development Level

Tbio 13 | 11,445
Tclin 3 | 613
Tchem 2 | 1,598

IMPC Phenotype

decreased hematocrit 2 | 46
edema 2 | 59
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal skin coloration 1 | 25
cardiovascular system phenotyp... 1 | 36
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged spleen 1 | 41
hemorrhage 1 | 23
improved glucose tolerance 1 | 79
increased circulating alkaline... 1 | 122
increased heart rate variabili... 1 | 7
increased monocyte cell number 1 | 63
long tibia 1 | 25
prenatal lethality prior to he... 1 | 87

Disease

osteosarcoma 15 | 7,950
Carcinoma 13 | 11,493
ovarian cancer 12 | 8,520
Cancer 11 | 2,499
lung cancer 11 | 4,740
Kidney cancer 10 | 2,613
ependymoma 10 | 4,679
glioblastoma 10 | 5,792
psoriasis 10 | 6,694
atypical teratoid / rhabdoid tumor 9 | 5,112
medulloblastoma, large-cell 9 | 6,241
adult high grade glioma 8 | 3,801
malignant mesothelioma 7 | 3,232
Astrocytoma, Pilocytic 6 | 3,081
subependymal giant cell astrocytoma 6 | 2,287
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
Hypertension 4 | 396
group 3 medulloblastoma 4 | 4,104
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
primary pancreatic ductal adenocarcinoma 4 | 1,109
primitive neuroectodermal tumor 4 | 3,035
Breast cancer 3 | 3,578
Cerebral Ischemia 3 | 37
Heart disease 3 | 306
Impotence 3 | 42
Kidney disease 3 | 430
Proteinuria 3 | 144
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
medulloblastoma 3 | 720
pituitary cancer 3 | 1,972
ulcerative colitis 3 | 1,819
Breast Neoplasms 2 | 445
Disease Models, Animal 2 | 155
Down syndrome 2 | 499
Duchenne muscular dystrophy 2 | 601
Endometrial cancer 2 | 311
Focal glomerulosclerosis 2 | 37
Glaucoma 2 | 239
Glomerulosclerosis, Focal Segmental 2 | 28
Hypertensive disease 2 | 292
Increase in blood pressure 2 | 119
Leukemia, Myelocytic, Acute 2 | 120
Liver Cirrhosis, Experimental 2 | 769
Multiple myeloma 2 | 1,332
Nausea and vomiting 2 | 97
Neoplasm Invasiveness 2 | 161
Neoplasm Metastasis 2 | 168
Neuropathy 2 | 261
Nonsyndromic deafness 2 | 142
Ocular hypertension 2 | 42
Pick disease 2 | 1,894
Prenatal Injuries 2 | 11
Prostatic Neoplasms 2 | 495
Sensorineural hearing loss 2 | 106
Spasm of cerebral arteries 2 | 3
Stomach Neoplasms 2 | 300
Thrombocytopenia 2 | 197
axial spondyloarthropathy 2 | 28
glioblastoma multiforme 2 | 142
hereditary spastic paraplegia 2 | 318
interstitial cystitis 2 | 2,312
juvenile dermatomyositis 2 | 1,187
mucosa-associated lymphoid tissue lymphoma 2 | 484
non diabetic and post-ischemic heart failure 2 | 200
pancreatic carcinoma 2 | 562
Bronchioloalveolar Adenocarcinoma 1 | 14
Carcinogenesis 1 | 8
Carcinoma, Ductal, Breast 1 | 11
Exanthem 1 | 37
Gallbladder Neoplasms 1 | 10
Gastric Cancer, Hereditary Diffuse 1 | 12
Glioma Susceptibility 1 1 | 5
Kidney Failure, Chronic 1 | 46
Lymphatic Metastasis 1 | 15
Lymphoma, T-Cell 1 | 13
Neoplasm of stomach 1 | 11
Neoplasms, Experimental 1 | 40
Non-small cell lung cancer, positive for epidermal growth factor receptor expression 1 | 4
Stomach Carcinoma 1 | 11
Stomach cancer 1 | 30
Stomatitis 1 | 21
T-Cell Lymphoma 1 | 13
end stage renal failure 1 | 8
gallbladder neoplasm 1 | 10

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 9 | 12,091
Kinase 5 | 634
Enzyme 4 | 4,145

Reactome Pathway

Sema4D induced cell migration ... 18 | 18
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Rho guanine nucleotide exchange factor 12 ARHGEF12 Tbio Non-IDG -2.63794 448.3 88
Rho-related GTP-binding protein RhoB RHOB Tbio Enzyme -2.41406 272.2 151
Myosin-11 MYH11 Tbio Non-IDG -2.63453 415.3 263
Myosin-14 MYH14 Tbio Non-IDG -1.41429 24.4 155
Myosin-10 MYH10 Tbio Non-IDG -1.77478 55.4 94
Myosin regulatory light polypeptide 9 MYL9 Tbio Non-IDG -2.50160 301.9 289
Rho-related GTP-binding protein Rho6 RND1 Tbio Enzyme -2.08631 119.8 60
Semaphorin-4D SEMA4D Tbio Non-IDG -2.18250 176.3 525
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.28550 20244.6 3859