Development Level

Tbio 96 | 10,625
Tchem 14 | 1,890
Tdark 7 | 7,003
Tclin 2 | 602

IMPC Term

preweaning lethality, complete... 4 | 633
embryonic lethality prior to o... 3 | 148
abnormal retina morphology 2 | 100
embryonic lethality prior to t... 2 | 187
abnormal behavior 1 | 226
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lung morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal spinal cord morpholog... 1 | 8
decreased caudal vertebrae num... 1 | 49
hypoactivity 1 | 89
increased NK cell number 1 | 19
increased bone mineral density 1 | 52
increased mean corpuscular vol... 1 | 91
increased thermal nociceptive ... 1 | 9

Disease

ovarian cancer 47 | 8,484
lung cancer 41 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,289
Multiple myeloma 30 | 1,327
medulloblastoma, large-cell 30 | 6,234
diabetes mellitus 27 | 1,663
Diamond-Blackfan anemia 23 | 28
osteosarcoma 23 | 7,933
sonic hedgehog group medulloblastoma 19 | 1,482
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
Waldenstrons macroglobulinemia 17 | 765
Cancer 16 | 2,346
glioblastoma 16 | 5,572
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
psoriasis 16 | 6,685
acute quadriplegic myopathy 14 | 1,157
malignant mesothelioma 14 | 3,162
Anemia, Diamond-Blackfan 13 | 15
atypical teratoid / rhabdoid tumor 13 | 4,369
astrocytoma 12 | 1,493
oligodendroglioma 12 | 2,849
cystic fibrosis 11 | 1,665
invasive ductal carcinoma 11 | 2,950
Anemia 9 | 252
Breast cancer 9 | 3,094
acute myeloid leukemia 9 | 780
colon cancer 9 | 1,475
lung adenocarcinoma 9 | 2,713
pancreatic cancer 9 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
Disease Progression 8 | 125
Stomach Neoplasms 8 | 282
adult high grade glioma 8 | 2,148
mucosa-associated lymphoid tissue lymphoma 8 | 480
non-small cell lung cancer 8 | 2,798
pediatric high grade glioma 8 | 2,712
pilocytic astrocytoma 8 | 3,086
primitive neuroectodermal tumor 8 | 3,031
group 3 medulloblastoma 7 | 2,254
subependymal giant cell astrocytoma 7 | 2,287
Hyperhomocysteinemia 6 | 34
Hypermethioninemia 6 | 12
Mammary Neoplasms 6 | 410
Neurodegenerative disease 6 | 383
Pick disease 6 | 1,893
adrenocortical carcinoma 6 | 1,427
inflammatory breast cancer 6 | 404
lung carcinoma 6 | 2,844
Duchenne muscular dystrophy 5 | 602
Epilepsy 5 | 346
Homocystinuria 5 | 23
Prostatic Neoplasms 5 | 471
juvenile dermatomyositis 5 | 1,189
medulloblastoma 5 | 1,524
pituitary cancer 5 | 1,972
tuberculosis 5 | 1,557
Parkinson Disease 4 | 102
Polycystic Ovary Syndrome 4 | 332
Weight Gain 4 | 87
astrocytic glioma 4 | 2,241
atypical teratoid/rhabdoid tumor 4 | 1,095
dermatomyositis 4 | 933
ependymoma 4 | 2,514
gastric carcinoma 4 | 832
glioblastoma multiforme 4 | 347
posterior fossa group A ependymoma 4 | 1,511
primary pancreatic ductal adenocarcinoma 4 | 1,271
progressive supranuclear palsy 4 | 674
ulcerative colitis 4 | 2,087
Amino Acid Metabolism, Inborn Errors 3 | 13
Amyotrophic Lateral Sclerosis 3 | 431
Animal Mammary Neoplasms 3 | 136
Anoxia 3 | 33
Atherosclerosis 3 | 275
Intellectual disability 3 | 573
Irregular astigmatism 3 | 11
Liver carcinoma 3 | 217
Mammary Neoplasms, Experimental 3 | 150
Pure red-cell aplasia 3 | 4
Rheumatoid Arthritis 3 | 1,160
Vascular disease 3 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
cutaneous lupus erythematosus 3 | 1,056
interstitial cystitis 3 | 2,299
non diabetic and post-ischemic heart failure 3 | 200
Cerebrovascular disease 2 | 231
Contact Dermatitis 2 | 80
Dementia 2 | 129
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Down syndrome 2 | 548
Hypertension 2 | 287
Myocardial Ischemia 2 | 169
Pellagra 2 | 25
Prostate cancer 2 | 172
active Crohn's disease 2 | 918
aldosterone-producing adenoma 2 | 664
breast carcinoma 2 | 1,614
head and neck cancer 2 | 270
hepatocellular carcinoma 2 | 532
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 119 | 17,995
Cardiovascular System 119 | 17,958
Digestive Tract 119 | 18,473
Female tissues 119 | 18,647
Liver and Pancreas 119 | 18,136
Male tissues 119 | 17,969
Nervous System 119 | 18,561
Endocrine System 118 | 18,512
Respiratory system 118 | 17,484
Urinary Tract 118 | 18,444
Skin and soft tissues 116 | 18,115

Target Family

Non-IDG 93 | 11,971
Enzyme 25 | 4,146
Kinase 1 | 634

Reactome Pathway

Selenoamino acid metabolism 119 | 119
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.04569 136.6 321
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
60S ribosomal protein L18 RPL18 Tbio Non-IDG -1.73537 50.7 134
60S ribosomal protein L38 RPL38 Tdark Non-IDG -1.39563 24.2 45
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
40S ribosomal protein S4, Y isoform 1 RPS4Y1 Tbio Non-IDG -1.22796 15.4 118
60S ribosomal protein L8 RPL8 Tbio Non-IDG -1.56871 36.4 182
40S ribosomal protein S3 RPS3 Tbio Non-IDG -2.16121 152.6 207
60S ribosomal protein L39 RPL39 Tbio Non-IDG 18.8 114
60S ribosomal protein L31 RPL31 Tbio Non-IDG -1.26053 17.9 99