Development Level

Tbio 17 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

decreased lean body mass 2 | 135
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
abnormal social-conspecific in... 1 | 3
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased lumbar vertebrae num... 1 | 2
decreased sacral vertebrae num... 1 | 1
enlarged heart 1 | 210
increased circulating calcium ... 1 | 34
increased circulating triglyce... 1 | 42
increased lumbar vertebrae num... 1 | 1
increased sacral vertebrae num... 1 | 1
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
thrombocytopenia 1 | 56

Disease

Cancer 15 | 2,499
Carcinoma 14 | 11,493
ovarian cancer 14 | 8,520
osteosarcoma 12 | 7,950
psoriasis 12 | 6,694
lung cancer 11 | 4,740
medulloblastoma, large-cell 9 | 6,241
atypical teratoid / rhabdoid tumor 8 | 5,112
Breast cancer 7 | 3,578
glioblastoma 7 | 5,792
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
malignant mesothelioma 5 | 3,232
non-small cell lung cancer 5 | 2,890
Breast Neoplasms 4 | 445
Kidney cancer 4 | 2,613
Mammary Neoplasms 4 | 425
Rheumatoid arthritis 4 | 1,191
Strabismus 4 | 270
active Crohn's disease 4 | 922
adult high grade glioma 4 | 3,801
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
oligodendroglioma 4 | 2,850
primitive neuroectodermal tumor 4 | 3,035
Amyotrophic lateral sclerosis 3 | 451
Astrocytoma, Pilocytic 3 | 3,081
Blepharoptosis 3 | 231
Broad flat nasal bridge 3 | 236
Cell Transformation, Neoplastic 3 | 97
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Epilepsy 3 | 792
Melanoma 3 | 711
Multiple myeloma 3 | 1,332
Nasal bridge wide 3 | 236
Neoplastic Cell Transformation 3 | 89
Nystagmus 3 | 317
Schizophrenia 3 | 1,160
Seizures 3 | 596
Waldenstrons macroglobulinemia 3 | 765
astrocytic glioma 3 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
juvenile dermatomyositis 3 | 1,187
pancreatic cancer 3 | 2,398
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819
Alcoholic Intoxication, Chronic 2 | 289
Arsenic Poisoning 2 | 62
Bilateral fifth finger clinodactyly 2 | 110
Brain Ischemia 2 | 110
Broad nasal tip 2 | 28
Byzanthine arch palate 2 | 194
Carcinoma, Non-Small-Cell Lung 2 | 107
Carcinoma, Renal Cell 2 | 124
Colonic Neoplasms 2 | 142
Colorectal Neoplasms 2 | 243
Craniofacial Abnormalities 2 | 151
Curvature of little finger 2 | 110
Endometriosis 2 | 540
Everted lower lip vermilion 2 | 54
Female infertility 2 | 30
Gonadoblastoma 2 | 34
Hair shaft abnormalities 2 | 30
Hemangioma 2 | 69
Hyperopia 2 | 70
Hypotrophic malar bone 2 | 129
Infertility, Male 2 | 46
Kidney disease 2 | 430
Lymphoma 2 | 81
Malar flattening 2 | 129
Male infertility 2 | 206
Microdontia (disorder) 2 | 59
Microphthalmia 2 | 76
Neurodegenerative disease 2 | 414
Nijmegen breakage syndrome 2 | 24
Pancreatic Neoplasm 2 | 85
Prostatic Neoplasms 2 | 495
Renal Cell Carcinoma 2 | 214
Sarcoma 2 | 62
Sensorineural Hearing Loss (disorder) 2 | 284
Skin cancer 2 | 469
Stomach Neoplasms 2 | 300
Telecanthus 2 | 62
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
fibroadenoma 2 | 559
hair abnormalities (non-specific) 2 | 30
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
non-small cell lung carcinoma 2 | 317
pituitary cancer 2 | 1,972
sonic hedgehog group medulloblastoma 2 | 467
tuberculosis 2 | 2,010

Tissue

Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Male tissues 19 | 17,142
Nervous System 19 | 16,725
Skin and soft tissues 19 | 17,230
Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Respiratory system 18 | 16,393
Urinary Tract 18 | 16,678
Liver and Pancreas 17 | 16,750

Target Family

Transcription Factor 13 | 1,400
Non-IDG 4 | 12,091
Enzyme 1 | 4,145
Epigenetic 1 | 242

Reactome Pathway

SUMOylation of transcription f... 19 | 19
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.74449 53.4 174
E3 SUMO-protein ligase PIAS1 PIAS1 Tbio Transcription Factor -1.86330 76.2 272
E3 SUMO-protein ligase PIAS2 PIAS2 Tbio Transcription Factor -1.84354 65.2 389
Transcription factor AP-2 gamma TFAP2C Tbio Transcription Factor -1.88406 72.7 269
Hypermethylated in cancer 1 protein HIC1 Tbio Transcription Factor -1.97301 107.0 199
SUMO-conjugating enzyme UBC9 UBE2I Tbio Non-IDG -2.45979 267.1 368
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.72599 482.7 786
Forkhead box protein L2 FOXL2 Tbio Transcription Factor -2.81557 652.1 234