Development Level

Tbio 59 | 10,625
Tdark 9 | 7,003
Tchem 7 | 1,890
Tclin 2 | 602

IMPC Term

preweaning lethality, complete... 9 | 633
preweaning lethality, incomple... 3 | 260
abnormal lens morphology 2 | 73
cataract 2 | 26
decreased bone mineral content 2 | 157
decreased lean body mass 2 | 195
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal digit morphology 1 | 13
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal social/conspecific in... 1 | 3
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating insulin ... 1 | 75
decreased grip strength 1 | 123
decreased mean corpuscular hem... 1 | 34
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
persistence of hyaloid vascula... 1 | 22
small spleen 1 | 11
small testis 1 | 37
tremors 1 | 34

Disease

ovarian cancer 52 | 8,492
osteosarcoma 50 | 7,933
lung cancer 37 | 4,473
medulloblastoma, large-cell 37 | 6,234
glioblastoma 30 | 5,572
psoriasis 29 | 6,685
group 3 medulloblastoma 25 | 2,254
primitive neuroectodermal tumor 25 | 3,031
Breast cancer 24 | 3,099
atypical teratoid / rhabdoid tumor 21 | 4,369
Cancer 20 | 2,346
malignant mesothelioma 20 | 3,163
Carcinoma 18 | 2,147
oligodendroglioma 18 | 2,849
dermatomyositis 17 | 967
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
non-small cell lung cancer 17 | 2,798
pediatric high grade glioma 15 | 2,712
Multiple myeloma 14 | 1,328
astrocytic glioma 13 | 2,241
pilocytic astrocytoma 13 | 3,086
Waldenstrons macroglobulinemia 12 | 765
ependymoma 12 | 2,514
Pick disease 11 | 1,893
Rheumatoid Arthritis 11 | 1,171
invasive ductal carcinoma 11 | 2,950
astrocytoma 10 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
adult high grade glioma 9 | 2,148
atypical teratoid/rhabdoid tumor 9 | 1,095
diabetes mellitus 9 | 1,663
acute quadriplegic myopathy 8 | 1,157
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
lung adenocarcinoma 8 | 2,714
sonic hedgehog group medulloblastoma 8 | 1,482
colon cancer 7 | 1,475
posterior fossa group A ependymoma 7 | 1,511
ductal carcinoma in situ 6 | 1,745
medulloblastoma 6 | 1,524
nasopharyngeal carcinoma 6 | 1,056
ulcerative colitis 6 | 2,087
Cornelia de Lange syndrome 5 | 21
Intellectual disability 5 | 573
breast carcinoma 5 | 1,614
cutaneous lupus erythematosus 5 | 1,056
group 4 medulloblastoma 5 | 1,875
juvenile dermatomyositis 5 | 1,189
pancreatic cancer 5 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
pituitary cancer 5 | 1,972
posterior fossa group B ependymoma 5 | 1,530
tuberculosis and treatment for 6 months 5 | 686
Atopic dermatitis 4 | 944
Bloom syndrome 4 | 30
Myeloid Leukemia 4 | 19
Nijmegen breakage syndrome 4 | 23
Peripheral Neuropathy 4 | 303
adrenocortical carcinoma 4 | 1,427
progressive supranuclear palsy 4 | 674
Amyotrophic Lateral Sclerosis 3 | 432
Bladder Neoplasm 3 | 109
Down syndrome 3 | 548
KBG syndrome 3 | 8
Kidney failure 3 | 41
Leukemia 3 | 88
Li-Fraumeni syndrome 3 | 13
Mammary Neoplasms 3 | 410
Melanoma 3 | 261
Neoplastic Syndromes, Hereditary 3 | 48
Primary cutaneous T-cell lymphoma 3 | 29
Prostatic Neoplasms 3 | 471
Werner syndrome 3 | 29
Xeroderma pigmentosum 3 | 41
acute myeloid leukemia 3 | 785
aldosterone-producing adenoma 3 | 664
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,563
Adenoid Cystic Carcinoma 2 | 99
Adenoma 2 | 165
Anemia 2 | 252
Animal Mammary Neoplasms 2 | 136
Atherosclerosis 2 | 275
Brain Ischemia 2 | 87
Cerebrovascular disease 2 | 231
Cockayne syndrome 2 | 54
Esophageal carcinoma 2 | 5
Fanconi's anemia 2 | 50
Glaucoma 2 | 135
Hypersensitivity reaction type II disease 2 | 235
Lung Neoplasms 2 | 171
Lymphoma 2 | 57
Mammary Neoplasms, Experimental 2 | 150
Microcephaly 2 | 149
Neurodegenerative disease 2 | 383
Pancreatic Neoplasm 2 | 79
Prostate cancer 2 | 172
Vascular disease 2 | 281
cystic fibrosis 2 | 1,670
hereditary spastic paraplegia 2 | 313
pancreatic carcinoma 2 | 567

Tissue

Blood and immune system 76 | 17,995
Endocrine System 76 | 18,512
Female tissues 76 | 18,647
Liver and Pancreas 76 | 18,136
Male tissues 76 | 17,969
Nervous System 76 | 18,561
Cardiovascular System 75 | 17,958
Digestive Tract 75 | 18,473
Respiratory system 74 | 17,484
Skin and soft tissues 74 | 18,115
Urinary Tract 74 | 18,444

Target Family

Non-IDG 57 | 11,969
Enzyme 11 | 4,146
Epigenetic 5 | 242
Transcription Factor 3 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

SUMOylation of DNA damage resp... 77 | 77
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.44719 274.6 177
Nuclear pore complex protein Nup133 NUP133 Tbio Non-IDG -1.34399 21.9 72
Non-structural maintenance of chromosomes element 1 homolog NSMCE1 Tdark Non-IDG 0.00000 87
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.46324 281.9 299
DNA repair protein XRCC4 XRCC4 Tbio Non-IDG -2.36590 222.7 297
Chromobox protein homolog 2 CBX2 Tchem Epigenetic -1.31842 21.1 181
Chromobox protein homolog 8 CBX8 Tchem Epigenetic -2.24493 171.6 351
Histone deacetylase 7 HDAC7 Tclin Epigenetic -1.99420 100.3 421
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.11484 12.8 160
Nuclear pore glycoprotein p62 NUP62 Tbio Non-IDG -1.75221 57.4 221