Development Level

Tbio 60 | 11,445
Tdark 8 | 6,588
Tchem 6 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 13 | 979
abnormal heart morphology 3 | 162
decreased lean body mass 3 | 135
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal digit morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal social-conspecific in... 1 | 3
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased food intake 1 | 13
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
edema 1 | 59
impaired glucose tolerance 1 | 75
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
small spleen 1 | 19
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 62 | 11,493
ovarian cancer 53 | 8,520
osteosarcoma 49 | 7,950
lung cancer 36 | 4,740
medulloblastoma, large-cell 36 | 6,241
group 3 medulloblastoma 35 | 4,104
glioblastoma 30 | 5,792
psoriasis 29 | 6,694
Breast cancer 27 | 3,578
atypical teratoid / rhabdoid tumor 27 | 5,112
primitive neuroectodermal tumor 25 | 3,035
ependymoma 22 | 4,679
Cancer 21 | 2,499
malignant mesothelioma 20 | 3,232
Kidney cancer 18 | 2,613
adult high grade glioma 18 | 3,801
oligodendroglioma 18 | 2,850
dermatomyositis 17 | 966
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
non-small cell lung cancer 17 | 2,890
astrocytic glioma 15 | 2,597
Astrocytoma, Pilocytic 14 | 3,081
Multiple myeloma 14 | 1,332
Waldenstrons macroglobulinemia 12 | 765
Pick disease 11 | 1,894
invasive ductal carcinoma 11 | 2,951
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
Intellectual disability 9 | 1,016
Rheumatoid arthritis 9 | 1,191
astrocytoma 9 | 1,146
Short stature 8 | 531
acute quadriplegic myopathy 8 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung adenocarcinoma 8 | 2,716
Autosomal recessive predisposition 7 | 1,442
Cryptorchidism 7 | 296
colon cancer 7 | 1,478
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Small head 6 | 374
Xeroderma pigmentosum 6 | 43
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
nasopharyngeal carcinoma 6 | 1,058
pediatric high grade glioma 6 | 1,064
tuberculosis 6 | 2,010
ulcerative colitis 6 | 1,819
Congenital hypoplasia of penis 5 | 176
Dull intelligence 5 | 645
Failure to gain weight 5 | 365
Fetal Growth Retardation 5 | 189
Hypoplastic mandible condyle 5 | 275
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Low intelligence 5 | 645
Mandibular hypoplasia 5 | 275
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Micrognathism 5 | 275
Pediatric failure to thrive 5 | 365
Poor school performance 5 | 645
Small hand 5 | 36
cutaneous lupus erythematosus 5 | 1,057
juvenile dermatomyositis 5 | 1,187
pancreatic cancer 5 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pituitary cancer 5 | 1,972
Amyotrophic lateral sclerosis 4 | 451
Atopic dermatitis 4 | 952
Attention deficit hyperactivity disorder 4 | 278
Bilateral fifth finger clinodactyly 4 | 110
Brachycephaly 4 | 88
Broad cranium shape 4 | 88
Curvature of little finger 4 | 110
Delayed bone age 4 | 136
Dilated ventricles (finding) 4 | 121
Downturned corners of mouth 4 | 48
Hypoplastic feet 4 | 66
Leukemia 4 | 104
Leukemia, Myeloid 4 | 18
Liver cancer 4 | 604
Lymphoma 4 | 81
Melanoma 4 | 711
Myeloid Leukemia 4 | 19
Nijmegen breakage syndrome 4 | 24
Photosensitivity of skin 4 | 51
Schizophrenia 4 | 1,160
Sensorineural Hearing Loss (disorder) 4 | 284
Severe mental retardation (I.Q. 20-34) 4 | 99
Short nose 4 | 132
Small nose 4 | 132
Thin lips 4 | 49
Thin upper lip vermilion 4 | 67
Vesico-Ureteral Reflux 4 | 33
Wide skull shape 4 | 88
adrenocortical carcinoma 4 | 1,428
group 4 medulloblastoma 4 | 1,855
progressive supranuclear palsy 4 | 676

Tissue

Blood and immune system 74 | 16,909
Digestive Tract 74 | 17,369
Endocrine System 74 | 18,159
Female tissues 74 | 17,400
Liver and Pancreas 74 | 16,750
Male tissues 74 | 17,142
Nervous System 74 | 16,725
Respiratory system 74 | 16,393
Skin and soft tissues 74 | 17,230
Urinary Tract 74 | 16,678
Cardiovascular System 73 | 15,192

Target Family

Non-IDG 56 | 12,091
Enzyme 11 | 4,145
Epigenetic 5 | 242
Transcription Factor 3 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

SUMOylation of DNA damage resp... 76 | 76
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
G/T mismatch-specific thymine DNA glycosylase TDG Tbio Enzyme -2.46252 297.6 225
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Chromobox protein homolog 8 CBX8 Tchem Epigenetic -2.27537 183.4 505
Chromobox protein homolog 2 CBX2 Tchem Epigenetic -1.37369 24.3 223
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169
Nuclear pore complex protein Nup85 NUP85 Tbio Non-IDG -1.23703 17.9 139
Structural maintenance of chromosomes protein 6 SMC6 Tbio Non-IDG -1.42371 20.0 115
Nuclear envelope pore membrane protein POM 121C POM121C Tdark Non-IDG 0.27 0.57 0
E3 SUMO-protein ligase CBX4 CBX4 Tchem Epigenetic -1.32793 21.9 353