Development Level

Tbio 89 | 11,445
Tchem 14 | 1,598
Tdark 8 | 6,588
Tclin 7 | 613

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 6 | 499
decreased lean body mass 4 | 135
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
cataract 3 | 92
enlarged heart 3 | 210
abnormal craniofacial morpholo... 2 | 33
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased mean corpuscular vol... 2 | 92
vertebral transformation 2 | 12
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal digit morphology 1 | 10
abnormal embryo turning 1 | 31
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal social-conspecific in... 1 | 3
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vitreous body morphol... 1 | 10
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased lumbar vertebrae num... 1 | 2
decreased mean corpuscular hem... 1 | 50
decreased sacral vertebrae num... 1 | 1
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased total retina thickne... 1 | 17
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
fusion of vertebral arches 1 | 7
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lumbar vertebrae num... 1 | 1
increased mean corpuscular hem... 1 | 96
increased sacral vertebrae num... 1 | 1
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
long tibia 1 | 25
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
sclerocornea 1 | 2
shortened QT interval 1 | 4
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 94 | 11,493
ovarian cancer 82 | 8,520
osteosarcoma 73 | 7,950
lung cancer 59 | 4,740
medulloblastoma, large-cell 57 | 6,241
group 3 medulloblastoma 54 | 4,104
glioblastoma 50 | 5,792
atypical teratoid / rhabdoid tumor 48 | 5,112
psoriasis 47 | 6,694
Cancer 45 | 2,499
Breast cancer 42 | 3,578
primitive neuroectodermal tumor 42 | 3,035
ependymoma 34 | 4,679
non-small cell lung cancer 31 | 2,890
malignant mesothelioma 30 | 3,232
adult high grade glioma 29 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
oligodendroglioma 27 | 2,850
Kidney cancer 26 | 2,613
astrocytic glioma 24 | 2,597
invasive ductal carcinoma 22 | 2,951
Multiple myeloma 21 | 1,332
dermatomyositis 20 | 966
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
Astrocytoma, Pilocytic 19 | 3,081
Waldenstrons macroglobulinemia 17 | 765
acute quadriplegic myopathy 17 | 1,158
Pick disease 16 | 1,894
Rheumatoid arthritis 15 | 1,191
astrocytoma 15 | 1,146
breast carcinoma 15 | 1,638
colon cancer 15 | 1,478
lung adenocarcinoma 15 | 2,716
adrenocortical carcinoma 14 | 1,428
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
Intellectual disability 12 | 1,016
Short stature 12 | 531
diabetes mellitus 12 | 1,728
juvenile dermatomyositis 12 | 1,187
pediatric high grade glioma 12 | 1,064
ulcerative colitis 12 | 1,819
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
Melanoma 11 | 711
nasopharyngeal carcinoma 11 | 1,058
pancreatic cancer 11 | 2,398
tuberculosis 11 | 2,010
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Schizophrenia 10 | 1,160
Small head 10 | 374
Autosomal recessive predisposition 9 | 1,442
Cryptorchidism 9 | 296
Endometriosis 9 | 540
cutaneous lupus erythematosus 9 | 1,057
cystic fibrosis 9 | 1,696
subependymal giant cell astrocytoma 9 | 2,287
Amyotrophic lateral sclerosis 8 | 451
Atopic dermatitis 8 | 952
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Prostatic Neoplasms 8 | 495
group 4 medulloblastoma 8 | 1,855
medulloblastoma 8 | 720
pituitary cancer 8 | 1,972
Bilateral fifth finger clinodactyly 7 | 110
Blepharoptosis 7 | 231
Byzanthine arch palate 7 | 194
Carcinoma, Squamous Cell 7 | 110
Concave bridge of nose 7 | 195
Curvature of little finger 7 | 110
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Xeroderma pigmentosum 7 | 43
interstitial cystitis 7 | 2,312
progressive supranuclear palsy 7 | 676
Colorectal Neoplasms 6 | 243
Fetal Growth Retardation 6 | 189
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Leukemia, Myeloid 6 | 18
Lung Neoplasms 6 | 232
Lymphoma 6 | 81
Myeloid Leukemia 6 | 19
Nijmegen breakage syndrome 6 | 24
Primary cutaneous T-cell lymphoma 6 | 29
Sensorineural Hearing Loss (disorder) 6 | 284
Small hand 6 | 36
Squamous cell carcinoma 6 | 129
Strabismus 6 | 270
Thin lips 6 | 49
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962

Tissue

Endocrine System 116 | 18,159
Female tissues 116 | 17,400
Male tissues 116 | 17,142
Nervous System 116 | 16,725
Skin and soft tissues 116 | 17,230
Blood and immune system 115 | 16,909
Digestive Tract 115 | 17,369
Respiratory system 115 | 16,393
Urinary Tract 115 | 16,678
Cardiovascular System 114 | 15,192
Liver and Pancreas 114 | 16,750

Target Family

Non-IDG 67 | 12,091
Enzyme 20 | 4,145
Transcription Factor 16 | 1,400
Epigenetic 12 | 242
Kinase 2 | 634
TF/Epigenetic 1 | 38

Reactome Pathway

SUMOylation 118 | 118
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
G/T mismatch-specific thymine DNA glycosylase TDG Tbio Enzyme -2.46252 297.6 225
Nucleolar protein 58 NOP58 Tbio Non-IDG -1.46442 30.0 85
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Chromodomain-helicase-DNA-binding protein 3 CHD3 Tbio Epigenetic -1.95633 85.2 190
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Chromobox protein homolog 8 CBX8 Tchem Epigenetic -2.27537 183.4 505
Chromobox protein homolog 2 CBX2 Tchem Epigenetic -1.37369 24.3 223
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169