Development Level

Tbio 12 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

decreased mature B cell number 1 | 7
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 13 | 11,493
Cancer 9 | 2,499
lung cancer 9 | 4,740
osteosarcoma 9 | 7,950
ovarian cancer 8 | 8,520
medulloblastoma, large-cell 7 | 6,241
glioblastoma 5 | 5,792
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
Breast cancer 4 | 3,578
Kidney cancer 4 | 2,613
Multiple Sclerosis 4 | 540
Systemic lupus erythematosus 4 | 194
Waldenstrons macroglobulinemia 4 | 765
atypical teratoid / rhabdoid tumor 4 | 5,112
lung carcinoma 4 | 2,843
subependymal giant cell astrocytoma 4 | 2,287
Astrocytoma, Pilocytic 3 | 3,081
Ataxia telangiectasia 3 | 34
Autosomal recessive predisposition 3 | 1,442
Dysarthria 3 | 192
Influenza 3 | 142
Multiple myeloma 3 | 1,332
Progressive disorder 3 | 142
Severe combined immunodeficiency 3 | 51
Telangiectasis 3 | 36
Werner syndrome 3 | 29
acute quadriplegic myopathy 3 | 1,158
juvenile dermatomyositis 3 | 1,187
psoriasis 3 | 6,694
Adenocarcinoma of lung 2 | 142
Adenoid Cystic Carcinoma 2 | 99
Adult onset 2 | 82
Aicardi-Goutieres syndrome 2 | 19
Allergic hypersensitivity disease 2 | 126
Asthma 2 | 385
Carcinoma, Adenoid Cystic 2 | 99
Cerebral atrophy 2 | 178
Chilblain lupus 1 2 | 3
Connective tissue disease 2 | 62
DNA ligase IV deficiency 2 | 7
Decreased tendon reflex 2 | 122
Disease Models, Animal 2 | 155
Dystonia 2 | 164
Dystonic disease 2 | 106
Encephalitis 2 | 64
Hantavirus pulmonary syndrome 2 | 6
Hypersensitivity reaction type II disease 2 | 253
Inflammatory bowel disease 2 | 151
Lung disease 2 | 142
Lupus erythematosus 2 | 57
Muscle Spasticity 2 | 195
Neurodegenerative disease 2 | 414
Nijmegen breakage syndrome 2 | 24
Purpura 2 | 43
Spider Veins 2 | 17
Thrombocytopenia 2 | 197
active Crohn's disease 2 | 922
adult high grade glioma 2 | 3,801
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
gastric carcinoma 2 | 807
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary Sjogren syndrome 2 | 735
primitive neuroectodermal tumor 2 | 3,035
ulcerative colitis 2 | 1,819
Abnormal visual pursuit 1 | 14
Aggressive systemic mastocytosis 1 | 20
Apathy 1 | 16
Apraxias 1 | 27
Autosomal dominant Robinow syndrome 1 1 | 15
Dysdiadochokinesis 1 | 25
Edema 1 | 81
Encephalopathy, progressive 1 | 6
Eosinophilic esophagitis 1 | 16
Exanthem 1 | 37
Hematuria 1 | 36
Hemiparesis 1 | 34
Hemiplegia and hemiparesis 1 | 38
Hereditary Breast and Ovarian Cancer Syndrome 1 | 14
Hyperthyroidism 1 | 53
Impaired smooth pursuit 1 | 14
Lower limb hyperreflexia 1 | 10
Lyme disease 1 | 26
Mast cell leukemia 1 | 13
Muscle Cramp 1 | 55
Nystagmus, End-Position 1 | 12
Progressive brain disease 1 | 6
Syphilis 1 | 17
Tetanus 1 | 68
Xeroderma pigmentosum 1 | 43

Tissue

Blood and immune system 15 | 16,909
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Male tissues 15 | 17,142
Skin and soft tissues 15 | 17,230
Cardiovascular System 14 | 15,192
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Urinary Tract 14 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 4 | 4,145
Kinase 2 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

STING mediated induction of ho... 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NLR family CARD domain-containing protein 3 NLRC3 Tbio Non-IDG 0.00000 29
E3 ubiquitin-protein ligase TRIM21 TRIM21 Tbio Enzyme -3.03008 1099.3 268
Gamma-interferon-inducible protein 16 IFI16 Tbio Non-IDG -1.96972 112.7 246
Signal transducer and activator of transcription 6 STAT6 Tchem Transcription Factor -2.91382 803.7 1033
Serine/threonine-protein kinase TBK1 TBK1 Tchem Kinase -2.76728 569.1 455
X-ray repair cross-complementing protein 5 XRCC5 Tbio Non-IDG -2.68622 470.8 874
DNA-dependent protein kinase catalytic subunit PRKDC Tchem Kinase -2.85973 723.4 1160
Stimulator of interferon genes protein TMEM173 Tbio Non-IDG -2.37722 230.3 450
Probable ATP-dependent RNA helicase DDX41 DDX41 Tbio Enzyme -3.62934 3930.0 230
Double-strand break repair protein MRE11 MRE11 Tbio Non-IDG -2.02762 98.5 459