Development Level

Tbio 98 | 11,651
Tdark 14 | 6,593
Tchem 2 | 1,388

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased circulating chloride... 2 | 41
increased or absent threshold ... 2 | 101
abnormal behavior 1 | 298
abnormal forebrain morphology 1 | 10
abnormal neural tube closure 1 | 46
decreased circulating glycerol... 1 | 16
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
prolonged QT interval 1 | 38
small adrenal glands 1 | 16
small spleen 1 | 19

Disease

ovarian cancer 49 | 8,520
lung cancer 37 | 4,740
Multiple myeloma 34 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
osteosarcoma 30 | 7,950
diabetes mellitus 29 | 1,728
medulloblastoma, large-cell 28 | 6,241
Diamond-Blackfan anemia 25 | 31
glioblastoma 21 | 5,792
Carcinoma 18 | 11,493
Waldenstrons macroglobulinemia 17 | 765
atypical teratoid / rhabdoid tumor 17 | 5,112
group 3 medulloblastoma 17 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
psoriasis 16 | 6,694
Breast cancer 14 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Abnormality of the urinary system 13 | 21
Anemia 13 | 365
Anemia, Diamond-Blackfan 13 | 16
Anemia, Macrocytic 13 | 18
Cardiac Arrhythmia 13 | 103
Cardiac conduction abnormalities 13 | 78
Cleft Palate 13 | 271
Conduction disorder of the heart 13 | 79
Delayed Puberty 13 | 97
EKG abnormalities 13 | 78
Electrocardiogram abnormal 13 | 81
Electrocardiogram change 13 | 78
Fatigue 13 | 182
Hand deformities 13 | 32
Intermittent migraine headaches 13 | 68
Migraine Disorders 13 | 76
Pallor 13 | 40
Uranostaphyloschisis 13 | 167
acute quadriplegic myopathy 13 | 1,158
genital abnormal 13 | 17
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
reproductive system abnormality 13 | 17
sonic hedgehog group medulloblastoma 12 | 467
invasive ductal carcinoma 11 | 2,951
lung adenocarcinoma 11 | 2,716
subependymal giant cell astrocytoma 11 | 2,287
Astrocytoma, Pilocytic 10 | 3,081
adult high grade glioma 10 | 3,801
astrocytoma 10 | 1,146
cystic fibrosis 10 | 1,696
ependymoma 10 | 4,679
oligodendroglioma 10 | 2,850
Disease Progression 8 | 136
Stomach Neoplasms 8 | 300
acute myeloid leukemia 8 | 783
primitive neuroectodermal tumor 8 | 3,035
dermatomyositis 7 | 966
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
pediatric high grade glioma 7 | 1,064
ulcerative colitis 7 | 1,819
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
colon cancer 6 | 1,478
juvenile dermatomyositis 6 | 1,187
mucosa-associated lymphoid tissue lymphoma 6 | 484
Adenocarcinoma of lung 5 | 142
Disease Models, Animal 5 | 155
Duchenne muscular dystrophy 5 | 601
Infantile onset 5 | 238
Prostatic Neoplasms 5 | 495
Reticulocytopenia 5 | 10
active Crohn's disease 5 | 922
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Hereditary spherocytosis type 4 4 | 18
Hypoplastic mandible condyle 4 | 275
Mandibular hypoplasia 4 | 275
Mental and motor retardation 4 | 608
Micrognathism 4 | 275
Parkinson Disease 4 | 64
Polycystic ovary syndrome 4 | 360
Shwachman-Diamond syndrome 4 | 17
astrocytic glioma 4 | 2,597
cutaneous lupus erythematosus 4 | 1,057
interstitial cystitis 4 | 2,312
lung carcinoma 4 | 2,843
primary pancreatic ductal adenocarcinoma 4 | 1,109
Alzheimer's disease 3 | 658
Cancer 3 | 2,499
Failure to gain weight 3 | 365
Gastroesophageal reflux disease 3 | 110
Heartburn 3 | 78
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Rheumatoid arthritis 3 | 1,191
Strabismus 3 | 270
Ventricular Septal Defects 3 | 119
breast carcinoma 3 | 1,638
glioblastoma multiforme 3 | 142
spina bifida 3 | 1,074

Tissue

Endocrine System 113 | 18,159
Blood and immune system 112 | 16,909
Digestive Tract 112 | 17,369
Male tissues 112 | 17,142
Skin and soft tissues 112 | 17,230
Cardiovascular System 111 | 15,192
Female tissues 111 | 17,400
Liver and Pancreas 111 | 16,750
Nervous System 111 | 16,725
Respiratory system 111 | 16,393
Urinary Tract 111 | 16,678

Target Family

Non-IDG 106 | 12,091
Enzyme 8 | 4,145

Reactome Pathway

SRP-dependent cotranslational ... 114 | 114
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L17 RPL17 Tbio Non-IDG -1.22337 16.5 217
Signal recognition particle receptor subunit beta SRPRB Tdark Non-IDG -0.45047 3.90 198
60S ribosomal protein L6 RPL6 Tbio Non-IDG -1.58528 37.8 68
Translocon-associated protein subunit gamma SSR3 Tdark Non-IDG -0.81733 5.86 34
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.68610 47.6 62
Signal recognition particle 9 kDa protein SRP9 Tbio Non-IDG -1.52679 31.8 33
60S ribosomal protein L18 RPL18 Tbio Non-IDG -1.45984 25.8 149
40S ribosomal protein S7 RPS7 Tbio Non-IDG -1.84836 69.5 112
Signal peptidase complex catalytic subunit SEC11C SEC11C Tdark Enzyme -0.46982 3.63 31
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 RPN2 Tbio Enzyme -1.51340 29.9 118