Development Level

Tbio 174 | 11,651
Tchem 38 | 1,388
Tdark 18 | 6,593
Tclin 13 | 612

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 10 | 499
abnormal bone structure 6 | 187
abnormal embryo size 5 | 220
decreased total body fat amoun... 5 | 207
abnormal sleep behavior 4 | 70
decreased bone mineral content 4 | 151
embryonic lethality prior to t... 4 | 278
increased circulating alkaline... 4 | 122
abnormal seminal vesicle morph... 3 | 114
decreased bone mineral density 3 | 126
decreased fasted circulating g... 3 | 65
decreased prepulse inhibition 3 | 82
embryonic lethality prior to o... 3 | 239
improved glucose tolerance 3 | 79
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
abnormal behavior 2 | 298
abnormal coat appearance 2 | 31
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal heart morphology 2 | 162
abnormal hindbrain development 2 | 16
abnormal lens morphology 2 | 81
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
cataract 2 | 92
decreased body length 2 | 101
decreased circulating choleste... 2 | 93
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
increased body length 2 | 32
increased circulating HDL chol... 2 | 80
increased circulating amylase ... 2 | 25
increased circulating creatini... 2 | 38
increased circulating sodium l... 2 | 71
increased grip strength 2 | 41
increased mean corpuscular vol... 2 | 92
abnormal body wall morphology 1 | 9
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal liver morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal spine curvature 1 | 9
abnormal spleen morphology 1 | 55
abnormal urinary bladder morph... 1 | 11
abnormal vitreous body morphol... 1 | 10
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
cystolithiasis 1 | 3
decreased caudal vertebrae num... 1 | 53
decreased circulating chloride... 1 | 30
decreased circulating creatine... 1 | 4
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
edema 1 | 59
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
enlarged thymus 1 | 5
enlarged urinary bladder 1 | 8
hyperactivity 1 | 148
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
long tibia 1 | 25
polycystic kidney 1 | 15
short tibia 1 | 97
small kidney 1 | 16
small spleen 1 | 19
thrombocytosis 1 | 27
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 198 | 11,493
ovarian cancer 102 | 8,520
osteosarcoma 100 | 7,950
glioblastoma 91 | 5,792
medulloblastoma, large-cell 90 | 6,241
psoriasis 87 | 6,694
ependymoma 78 | 4,679
atypical teratoid / rhabdoid tumor 75 | 5,112
lung cancer 62 | 4,740
group 3 medulloblastoma 61 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,291
pancreatic cancer 53 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 51 | 2,989
adult high grade glioma 49 | 3,801
lung carcinoma 48 | 2,843
Breast cancer 47 | 3,578
malignant mesothelioma 46 | 3,232
non-small cell lung cancer 46 | 2,890
Astrocytoma, Pilocytic 44 | 3,081
primitive neuroectodermal tumor 44 | 3,035
Autosomal recessive predisposition 43 | 1,442
lung adenocarcinoma 42 | 2,716
pituitary cancer 42 | 1,972
invasive ductal carcinoma 40 | 2,951
oligodendroglioma 38 | 2,850
cystic fibrosis 37 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,962
tuberculosis 36 | 2,010
colon cancer 34 | 1,478
astrocytic glioma 33 | 2,597
interstitial cystitis 33 | 2,312
Schizophrenia 32 | 1,160
Cancer 31 | 2,499
Kidney cancer 30 | 2,613
active Crohn's disease 30 | 922
subependymal giant cell astrocytoma 30 | 2,287
Epilepsy 29 | 792
Pick disease 29 | 1,894
active ulcerative colitis 29 | 764
diabetes mellitus 28 | 1,728
ductal carcinoma in situ 28 | 1,745
ulcerative colitis 26 | 1,819
Rheumatoid arthritis 23 | 1,191
pediatric high grade glioma 22 | 1,064
nephrosclerosis 21 | 333
Obesity 20 | 678
primary pancreatic ductal adenocarcinoma 20 | 1,109
Bipolar Disorder 19 | 666
Seizures 19 | 596
adrenocortical carcinoma 19 | 1,428
Alzheimer's disease 18 | 658
Metabolic acidosis 18 | 90
cutaneous lupus erythematosus 18 | 1,057
group 4 medulloblastoma 18 | 1,855
breast carcinoma 17 | 1,638
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Intellectual disability 16 | 1,016
Kidney disease 16 | 430
Mental and motor retardation 16 | 608
nasopharyngeal carcinoma 16 | 1,058
acute quadriplegic myopathy 14 | 1,158
astrocytoma 14 | 1,146
gastric carcinoma 14 | 807
Hypertension 13 | 396
Hypoglycemia 13 | 152
Liver Cirrhosis, Experimental 13 | 769
Muscle hypotonia 13 | 571
Parkinson's disease 13 | 392
non primary Sjogren syndrome sicca 13 | 891
Atopic dermatitis 12 | 952
Depressive disorder 12 | 409
Diarrhea 12 | 253
Endometriosis 12 | 540
Melanoma 12 | 711
juvenile dermatomyositis 12 | 1,187
Alcoholic Intoxication, Chronic 11 | 289
Diastrophic dysplasia 11 | 21
Down syndrome 11 | 499
Dull intelligence 11 | 645
Failure to gain weight 11 | 365
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Multiple myeloma 11 | 1,332
Pediatric failure to thrive 11 | 365
Poor school performance 11 | 645
Short stature 11 | 531
aldosterone-producing adenoma 11 | 665
esophageal adenocarcinoma 11 | 737
mucosa-associated lymphoid tissue lymphoma 11 | 484
pancreatic carcinoma 11 | 562
progressive supranuclear palsy 11 | 676
spina bifida 11 | 1,074
Acquired metabolic disease 10 | 336
Hepatomegaly 10 | 285
Mental Depression 10 | 333
Nephrolithiasis 10 | 56
acute myeloid leukemia 10 | 783

Tissue

Endocrine System 234 | 18,159
Digestive Tract 230 | 17,369
Urinary Tract 228 | 16,678
Female tissues 226 | 17,400
Male tissues 224 | 17,142
Nervous System 224 | 16,725
Liver and Pancreas 221 | 16,750
Skin and soft tissues 221 | 17,230
Blood and immune system 215 | 16,909
Respiratory system 204 | 16,393
Cardiovascular System 184 | 15,192

Target Family

Transporter 220 | 473
Non-IDG 20 | 12,091
Ion Channel 2 | 344
Transcription Factor 1 | 1,400

Reactome Pathway

SLC-mediated transmembrane tra... 243 | 243
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sialin SLC17A5 Tbio Transporter -2.93541 845.6 63
Proton-coupled amino acid transporter 4 SLC36A4 Tbio Transporter -1.46987 30.6 45
Sodium/hydrogen exchanger 5 SLC9A5 Tbio Transporter -1.15040 17.1 43
Monocarboxylate transporter 3 SLC16A8 Tbio Transporter -1.52718 33.5 105
High affinity cationic amino acid transporter 1 SLC7A1 Tbio Transporter -2.71485 501.4 143
Solute carrier organic anion transporter family member 1B1 SLCO1B1 Tchem Transporter -2.77788 574.0 124
Zinc transporter ZIP1 SLC39A1 Tbio Transporter -1.89903 75.9 61
Sodium/myo-inositol cotransporter 2 SLC5A11 Tchem Transporter -1.76250 46.1 82
Proton myo-inositol cotransporter SLC2A13 Tbio Transporter -1.10021 10.8 71
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.61544 427.2 413