Development Level

Tbio 176 | 10,625
Tchem 61 | 1,890
Tdark 30 | 7,003
Tclin 13 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 13 | 633
decreased total body fat amoun... 7 | 186
preweaning lethality, incomple... 6 | 260
abnormal bone structure 5 | 131
decreased bone mineral density 5 | 126
increased grip strength 5 | 83
decreased bone mineral content 4 | 157
decreased lean body mass 4 | 195
increased circulating alkaline... 4 | 119
abnormal retina morphology 3 | 100
decreased fasted circulating g... 3 | 49
decreased rib number 3 | 59
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 93
abnormal behavior 2 | 226
abnormal coat appearance 2 | 25
abnormal lens morphology 2 | 73
abnormal retinal pigmentation 2 | 61
decreased body length 2 | 108
decreased hemoglobin content 2 | 53
decreased mean corpuscular vol... 2 | 50
impaired glucose tolerance 2 | 52
impaired righting response 2 | 19
improved glucose tolerance 2 | 56
increased circulating amylase ... 2 | 13
increased circulating creatini... 2 | 29
increased mean corpuscular vol... 2 | 91
short tibia 2 | 82
straub tail 2 | 26
abnormal cervical vertebrae mo... 1 | 4
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal digit morphology 1 | 13
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal incisor color 1 | 2
abnormal iris morphology 1 | 12
abnormal iris transilluminatio... 1 | 1
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal spine curvature 1 | 7
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 7
absent pinna reflex 1 | 21
absent teeth 1 | 4
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased CD4-positive, CD25-p... 1 | 24
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased erythrocyte cell num... 1 | 43
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged thymus 1 | 4
eyelids fail to open 1 | 2
hyperactivity 1 | 108
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased startle reflex 1 | 38
kyphosis 1 | 5
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
rib fusion 1 | 2
sparse hair 1 | 6
thrombocytosis 1 | 23
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 124 | 8,484
osteosarcoma 122 | 7,933
medulloblastoma, large-cell 109 | 6,234
psoriasis 99 | 6,685
glioblastoma 98 | 5,572
lung cancer 82 | 4,466
atypical teratoid / rhabdoid tumor 73 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 61 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 60 | 2,956
pediatric high grade glioma 60 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 56 | 2,988
non-small cell lung cancer 56 | 2,798
malignant mesothelioma 55 | 3,162
primitive neuroectodermal tumor 55 | 3,031
pancreatic cancer 54 | 2,300
Breast cancer 51 | 3,094
ependymoma 50 | 2,514
lung carcinoma 50 | 2,844
pilocytic astrocytoma 50 | 3,086
group 3 medulloblastoma 46 | 2,254
invasive ductal carcinoma 44 | 2,950
lung adenocarcinoma 44 | 2,713
oligodendroglioma 44 | 2,849
pituitary cancer 42 | 1,972
colon cancer 38 | 1,475
ulcerative colitis 38 | 2,087
astrocytic glioma 37 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
group 4 medulloblastoma 36 | 1,875
Cancer 35 | 2,346
Carcinoma 35 | 2,147
cystic fibrosis 35 | 1,665
Pick disease 34 | 1,893
interstitial cystitis 34 | 2,299
subependymal giant cell astrocytoma 32 | 2,287
tuberculosis 32 | 1,557
diabetes mellitus 31 | 1,663
ductal carcinoma in situ 30 | 1,745
active Crohn's disease 27 | 918
atypical teratoid/rhabdoid tumor 27 | 1,095
primary pancreatic ductal adenocarcinoma 26 | 1,271
Rheumatoid Arthritis 25 | 1,160
posterior fossa group B ependymoma 25 | 1,530
adult high grade glioma 24 | 2,148
posterior fossa group A ependymoma 24 | 1,511
astrocytoma 23 | 1,493
sonic hedgehog group medulloblastoma 23 | 1,482
adrenocortical carcinoma 22 | 1,427
nephrosclerosis 22 | 329
Epilepsy 21 | 346
Obesity 21 | 616
acute quadriplegic myopathy 19 | 1,157
breast carcinoma 19 | 1,614
cutaneous lupus erythematosus 19 | 1,056
dermatomyositis 18 | 933
nasopharyngeal carcinoma 18 | 1,056
Schizophrenia 17 | 501
gastric carcinoma 17 | 832
Alzheimer's disease 16 | 644
Kidney disease 16 | 396
Multiple myeloma 16 | 1,327
Atopic dermatitis 15 | 944
Hypoglycemia 15 | 81
Metabolic acidosis 15 | 49
active ulcerative colitis 15 | 477
medulloblastoma 15 | 1,524
aldosterone-producing adenoma 13 | 664
juvenile dermatomyositis 13 | 1,189
spina bifida 13 | 1,064
Endometriosis 12 | 535
Hyperglycemia 12 | 120
acute myeloid leukemia 12 | 780
esophageal adenocarcinoma 12 | 737
mucosa-associated lymphoid tissue lymphoma 12 | 480
non primary Sjogren syndrome sicca 12 | 840
pancreatic carcinoma 12 | 567
progressive supranuclear palsy 12 | 674
Amyotrophic Lateral Sclerosis 11 | 431
Diastrophic dysplasia 11 | 21
Down syndrome 11 | 548
Hyperuricemia 11 | 35
Parkinson's disease 11 | 364
Waldenstrons macroglobulinemia 11 | 765
IGA Glomerulonephritis 10 | 454
Neurodegenerative disease 10 | 383
Prostatic Neoplasms 10 | 471
Acquired metabolic disease 9 | 267
Diarrhea 9 | 155
Hypertension 9 | 287
Lysinuric protein intolerance 9 | 15
Mammary Neoplasms 9 | 410
Metabolic syndrome X 9 | 155
Seizures 9 | 95
glioblastoma multiforme 9 | 347
Duchenne muscular dystrophy 8 | 602
Intellectual disability 8 | 573
Nephrolithiasis 8 | 30
Type 2 diabetes mellitus 8 | 189
gastric cancer 8 | 430
tuberculosis and treatment for 6 months 8 | 686

Tissue

Endocrine System 279 | 18,512
Female tissues 279 | 18,647
Nervous System 279 | 18,561
Digestive Tract 278 | 18,473
Liver and Pancreas 277 | 18,136
Skin and soft tissues 276 | 18,115
Urinary Tract 276 | 18,444
Blood and immune system 274 | 17,995
Male tissues 273 | 17,969
Cardiovascular System 271 | 17,958
Respiratory system 264 | 17,484

Target Family

Transporter 219 | 473
Non-IDG 47 | 11,971
Enzyme 7 | 4,146
Kinase 4 | 634
Ion Channel 2 | 341
Transcription Factor 1 | 1,400

Reactome Pathway

SLC-mediated transmembrane tra... 280 | 280
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18
Equilibrative nucleoside transporter 4 SLC29A4 Tbio Transporter -1.79381 73.1 189
Monocarboxylate transporter 8 SLC16A2 Tbio Transporter -2.32240 230.6 103
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Sodium/hydrogen exchanger 4 SLC9A4 Tdark Transporter -1.25841 17.4 6
Equilibrative nucleoside transporter 3 SLC29A3 Tbio Transporter -2.36515 247.3 58
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Sodium/nucleoside cotransporter 2 SLC28A2 Tchem Transporter -1.78327 62.8 105