Development Level

Tbio 18 | 10,625
Tdark 13 | 7,003
Tchem 2 | 1,890

IMPC Term

preweaning lethality, incomple... 2 | 260
abnormal iris morphology 1 | 12
abnormal maxilla morphology 1 | 16
abnormal placement of pupils 1 | 4
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
decreased rib number 1 | 59
increased circulating chloride... 1 | 43
increased or absent threshold ... 1 | 128
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15

Disease

ovarian cancer 15 | 8,484
psoriasis 14 | 6,685
Breast cancer 12 | 3,094
lung cancer 12 | 4,466
invasive ductal carcinoma 9 | 2,950
lung adenocarcinoma 9 | 2,713
Cancer 8 | 2,346
ductal carcinoma in situ 8 | 1,745
osteosarcoma 8 | 7,933
breast carcinoma 7 | 1,614
malignant mesothelioma 7 | 3,162
Multiple myeloma 6 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
non-small cell lung cancer 6 | 2,798
colon cancer 5 | 1,475
cystic fibrosis 5 | 1,665
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
non-small cell lung carcinoma 5 | 413
pancreatic cancer 5 | 2,300
Mammary Neoplasms 4 | 410
atypical teratoid / rhabdoid tumor 4 | 4,369
cutaneous lupus erythematosus 4 | 1,056
glioblastoma 4 | 5,572
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
group 3 medulloblastoma 3 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
nasopharyngeal carcinoma 3 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pituitary cancer 3 | 1,972
spina bifida 3 | 1,064
Endometriosis 2 | 535
Huntington's disease 2 | 72
Thyroiditis 2 | 25
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 780
adrenocortical carcinoma 2 | 1,427
diabetes mellitus 2 | 1,663
gastric cancer 2 | 430
lung carcinoma 2 | 2,844
medulloblastoma, large-cell 2 | 6,234
pancreatic carcinoma 2 | 567
posterior fossa group A ependymoma 2 | 1,511
subependymal giant cell astrocytoma 2 | 2,287
Acute kidney injury 1 | 65
Alzheimer's disease 1 | 644
Ankylosing spondylitis 1 | 138
Arsenic Poisoning 1 | 59
Atherosclerosis 1 | 275
Atopic dermatitis 1 | 944
Autistic Disorder 1 | 320
Autoimmune Diseases 1 | 33
Autosomal dominant cerebellar ataxia 1 | 34
Bipolar Disorder 1 | 266
Brain infarction 1 | 17
Cerebellar Ataxia 1 | 72
Choreatic disease 1 | 27
Chronic Lymphocytic Leukemia 1 | 242
Chronic obstructive pulmonary disease 1 | 146
Colitis 1 | 46
Dementia 1 | 129
Dermatologic disorders 1 | 65
Diabetes Mellitus, Experimental 1 | 106
Diabetes Mellitus, Non-Insulin-Dependent 1 | 157
Dystonia 1 | 77
Fanconi's anemia 1 | 50
Fatty Liver 1 | 48
Fatty liver disease 1 | 84
Fibrosis 1 | 40
HIV Infections 1 | 100
Heart disease 1 | 279
IGA Glomerulonephritis 1 | 454
Influenza 1 | 142
Kidney disease 1 | 396
Machado-Joseph disease 1 | 18
Malaria 1 | 140
Metabolic syndrome X 1 | 155
Neoplasm Recurrence, Local 1 | 23
Neurodegenerative disease 1 | 383
Nijmegen breakage syndrome 1 | 23
Non-alcoholic Fatty Liver Disease 1 | 40
Orchitis 1 | 16
Paralysed 1 | 9
Parkinson's disease 1 | 364
Pneumonia 1 | 133
Primary ciliary dyskinesia 1 | 73
Seckel syndrome 1 | 34
Squamous cell carcinoma of esophagus 1 | 82
Testicular cancer 1 | 24
Vaccinia 1 | 37
active Crohn's disease 1 | 918
atypical teratoid/rhabdoid tumor 1 | 1,095
chorea-acanthocytosis 1 | 11
dentatorubral-pallidoluysian atrophy 1 | 21
medulloblastoma 1 | 1,524
tuberculosis 1 | 1,557
tuberculosis and treatment for 3 months 1 | 327

Tissue

Female tissues 33 | 18,647
Male tissues 33 | 17,969
Blood and immune system 32 | 17,995
Cardiovascular System 32 | 17,958
Digestive Tract 32 | 18,473
Endocrine System 32 | 18,512
Nervous System 32 | 18,561
Urinary Tract 32 | 18,444
Liver and Pancreas 31 | 18,136
Respiratory system 31 | 17,484
Skin and soft tissues 25 | 18,115

Target Family

Non-IDG 26 | 11,971
Enzyme 5 | 4,146
Epigenetic 2 | 242

Reactome Pathway

SIRT1 negatively regulates rRN... 33 | 33
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Histone H2A.V H2AFV Tdark Non-IDG -1.20240 14.0 30
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.36 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.48218 30.2 48
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.12825 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2A.J H2AFJ Tdark Non-IDG 0.28 0.61 90
Ribosomal RNA-processing protein 8 RRP8 Tbio Enzyme -2.24237 174.5 99
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.18679 149.4 267
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.31612 18.9 109