Development Level

Tbio 18 | 10,625
Tdark 13 | 7,003
Tchem 2 | 1,890

IMPC Phenotype

preweaning lethality, incomple... 2 | 260
abnormal iris morphology 1 | 12
abnormal maxilla morphology 1 | 16
abnormal placement of pupils 1 | 4
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
decreased rib number 1 | 59
increased circulating chloride... 1 | 43
increased or absent threshold ... 1 | 128
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15

Disease

ovarian cancer 15 | 8,491
psoriasis 14 | 6,685
Breast cancer 12 | 3,098
lung cancer 12 | 4,473
invasive ductal carcinoma 9 | 2,950
lung adenocarcinoma 9 | 2,714
Cancer 8 | 2,346
ductal carcinoma in situ 8 | 1,745
osteosarcoma 8 | 7,933
breast carcinoma 7 | 1,614
malignant mesothelioma 7 | 3,163
Multiple myeloma 6 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
non-small cell lung cancer 6 | 2,798
colon cancer 5 | 1,475
cystic fibrosis 5 | 1,670
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
non-small cell lung carcinoma 5 | 413
pancreatic cancer 5 | 2,300
Mammary Neoplasms 4 | 410
atypical teratoid / rhabdoid tumor 4 | 4,369
cutaneous lupus erythematosus 4 | 1,056
glioblastoma 4 | 5,572
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
group 3 medulloblastoma 3 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
nasopharyngeal carcinoma 3 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pituitary cancer 3 | 1,972
spina bifida 3 | 1,064
Endometriosis 2 | 535
Huntington's disease 2 | 72
Thyroiditis 2 | 25
Waldenstrons macroglobulinemia 2 | 764
acute myeloid leukemia 2 | 785
adrenocortical carcinoma 2 | 1,427
diabetes mellitus 2 | 1,663
gastric cancer 2 | 436
lung carcinoma 2 | 2,844
medulloblastoma, large-cell 2 | 6,234
pancreatic carcinoma 2 | 567
posterior fossa group A ependymoma 2 | 1,511
subependymal giant cell astrocytoma 2 | 2,287
Acute kidney injury 1 | 65
Alzheimer's disease 1 | 644
Ankylosing spondylitis 1 | 138
Arsenic Poisoning 1 | 59
Atherosclerosis 1 | 275
Atopic dermatitis 1 | 944
Autistic Disorder 1 | 320
Autoimmune Diseases 1 | 33
Autosomal dominant cerebellar ataxia 1 | 34
Bipolar Disorder 1 | 266
Brain infarction 1 | 17
Cerebellar Ataxia 1 | 72
Choreatic disease 1 | 27
Chronic obstructive pulmonary disease 1 | 147
Colitis 1 | 46
Dementia 1 | 129
Dermatologic disorders 1 | 65
Diabetes Mellitus, Experimental 1 | 106
Diabetes Mellitus, Non-Insulin-Dependent 1 | 161
Dystonia 1 | 77
Fanconi's anemia 1 | 50
Fatty Liver 1 | 48
Fatty liver disease 1 | 86
Fibrosis 1 | 40
HIV Infections 1 | 99
Heart disease 1 | 279
IGA Glomerulonephritis 1 | 454
Influenza 1 | 142
Kidney disease 1 | 397
Machado-Joseph disease 1 | 18
Malaria 1 | 140
Male infertility 1 | 170
Metabolic syndrome X 1 | 155
Neoplasm Recurrence, Local 1 | 23
Neurodegenerative disease 1 | 383
Nijmegen breakage syndrome 1 | 23
Non-alcoholic Fatty Liver Disease 1 | 40
Orchitis 1 | 16
Paralysed 1 | 9
Parkinson's disease 1 | 364
Pneumonia 1 | 133
Primary ciliary dyskinesia 1 | 75
Seckel syndrome 1 | 35
Squamous cell carcinoma of esophagus 1 | 82
Testicular cancer 1 | 24
Vaccinia 1 | 37
active Crohn's disease 1 | 918
atypical teratoid/rhabdoid tumor 1 | 1,095
chorea-acanthocytosis 1 | 11
dentatorubral-pallidoluysian atrophy 1 | 21
medulloblastoma 1 | 1,524
tuberculosis 1 | 1,563
tuberculosis and treatment for 3 months 1 | 327

Tissue

Female tissues 33 | 18,646
Male tissues 33 | 17,968
Blood and immune system 32 | 17,994
Cardiovascular System 32 | 17,957
Digestive Tract 32 | 18,472
Endocrine System 32 | 18,511
Nervous System 32 | 18,560
Urinary Tract 32 | 18,443
Liver and Pancreas 31 | 18,135
Respiratory system 31 | 17,483
Skin and soft tissues 25 | 18,114

Target Family

Non-IDG 26 | 11,969
Enzyme 5 | 4,146
Epigenetic 2 | 242

Reactome Pathway

SIRT1 negatively regulates rRN... 33 | 33
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Ribosomal RNA-processing protein 8 RRP8 Tbio Enzyme -2.24766 174.5 99
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.21810 149.4 267
Histone H2B type 1-O HIST1H2BO Tdark Non-IDG -0.27142 0.81 50
Histone H2A.Z H2AFZ Tbio Non-IDG -2.48248 304.4 245
NAD-dependent protein deacetylase sirtuin-1 SIRT1 Tchem Epigenetic -3.43962 2958.6 656