Development Level

Tbio 11 | 10,625
Tchem 8 | 1,890
Tclin 1 | 602

IMPC Phenotype

embryonic lethality prior to t... 2 | 187
preweaning lethality, complete... 2 | 633
abnormal body wall morphology 1 | 7
abnormal embryo size 1 | 112
abnormal motor learning 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
cataract 1 | 26
cleft palate 1 | 6
decreased bone mineral content 1 | 157
enlarged heart 1 | 111
immune system phenotype 1 | 17
increased startle reflex 1 | 38
limb grasping 1 | 35

Disease

Cancer 13 | 2,346
ovarian cancer 10 | 8,491
lung cancer 8 | 4,473
group 3 medulloblastoma 7 | 2,254
osteosarcoma 7 | 7,933
psoriasis 7 | 6,685
Breast cancer 5 | 3,098
diabetes mellitus 5 | 1,663
invasive ductal carcinoma 5 | 2,950
medulloblastoma, large-cell 5 | 6,234
Carcinoma 4 | 2,147
Liver carcinoma 4 | 217
Noonan Syndrome 4 | 33
Parkinson's disease 4 | 364
ductal carcinoma in situ 4 | 1,745
glioblastoma 4 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
juvenile dermatomyositis 4 | 1,189
malignant mesothelioma 4 | 3,163
non-small cell lung cancer 4 | 2,798
Adenoid Cystic Carcinoma 3 | 99
Adenoma 3 | 165
Cardiofaciocutaneous syndrome 3 | 15
Cleft Lip 3 | 91
Cleft palate 3 | 125
Connective tissue cancer 3 | 9
Costello Syndrome 3 | 18
Craniosynostosis 3 | 47
Diarrhea 3 | 155
Down syndrome 3 | 548
Epidermal nevus syndrome 3 | 3
Heart disease 3 | 279
Liver Cirrhosis 3 | 101
Lung Neoplasms 3 | 171
Mammary Neoplasms 3 | 410
Neoplasms, Experimental 3 | 33
Neuroblastoma 3 | 78
Nevus, Epidermal 3 | 5
Papillary thyroid carcinoma 3 | 37
Synostosis 3 | 18
Thyroid cancer 3 | 25
astrocytoma 3 | 1,493
atypical teratoid / rhabdoid tumor 3 | 4,369
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
breast carcinoma 3 | 1,614
ependymoma 3 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
lung adenocarcinoma 3 | 2,714
non-small cell lung carcinoma 3 | 413
oligodendroglioma 3 | 2,849
pancreatic cancer 3 | 2,300
pediatric high grade glioma 3 | 2,712
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,271
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 2,087
AMYOTROPHIC LATERAL SCLEROSIS 1 2 | 49
Adenocarcinoma 2 | 115
Autistic Disorder 2 | 320
Bladder Neoplasm 2 | 109
Cardiomegaly 2 | 66
Colorectal Neoplasms 2 | 217
DOID:9917 2 | 4
Disease Progression 2 | 125
Exanthem 2 | 39
Familial adenomatous polyposis 2 | 33
Hemangiosarcoma 2 | 18
Hepatitis C 2 | 90
Immune system cancer 2 | 38
Irritable bowel syndrome 2 | 59
Juvenile Myelomonocytic Leukemia 2 | 21
Kidney cancer 2 | 121
Liver Neoplasms, Experimental 2 | 48
Liver neoplasms 2 | 108
Lymphoid leukemia 2 | 69
Lymphoma 2 | 57
Lynch syndrome 2 | 35
Melanocytic Nevus Syndrome, Congenital 2 | 3
Mesothelioma 2 | 40
Mouth Neoplasms 2 | 44
Myocardial Ischemia 2 | 169
Neoplasm Invasiveness 2 | 127
Neutropenia 2 | 78
Pancreatitis 2 | 97
Paronychia 2 | 7
Penile Neoplasms 2 | 4
Plummer's disease 2 | 7
Pulmonary Fibrosis 2 | 66
Squamous cell carcinoma 2 | 96
Stomach Neoplasms 2 | 282
Thyroid Neoplasm 2 | 33
Upper respiratory tract disease 2 | 7
Vascular disease 2 | 281
atypical teratoid/rhabdoid tumor 2 | 1,095
cystic fibrosis 2 | 1,670
fibroadenoma 2 | 557
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
nasopharyngeal carcinoma 2 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pilocytic astrocytoma 2 | 3,086

Tissue

Digestive Tract 20 | 18,472
Endocrine System 20 | 18,511
Female tissues 20 | 18,646
Nervous System 20 | 18,560
Skin and soft tissues 20 | 18,114
Urinary Tract 20 | 18,443
Liver and Pancreas 19 | 18,135
Blood and immune system 18 | 17,994
Cardiovascular System 18 | 17,957
Male tissues 17 | 17,968
Respiratory system 16 | 17,483

Target Family

Non-IDG 15 | 11,969
Enzyme 4 | 4,146
Kinase 1 | 634

Reactome Pathway

SHC-mediated cascade:FGFR4 20 | 20
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
GTPase NRas NRAS Tchem Enzyme -2.98048 880.4 265
Beta-klotho KLB Tbio Enzyme -1.95818 69.9 47
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.74106 54.5 120
Fibroblast growth factor 1 FGF1 Tchem Non-IDG -3.19895 1583.2 445
Fibroblast growth factor receptor 4 FGFR4 Tclin Kinase -2.40965 255.8 442
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.00519 933.5 424
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -3.99298 10115.4 658
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.66315 426.6 126