Development Level

Tbio 16 | 11,651
Tchem 5 | 1,388
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal embryo size 2 | 220
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
embryonic lethality prior to t... 2 | 278
impaired pupillary reflex 2 | 26
increased circulating choleste... 2 | 66
abnormal body wall morphology 1 | 9
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased spleen weight 1 | 10
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating glucose ... 1 | 24
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 15 | 2,499
lung cancer 11 | 4,740
Carcinoma 10 | 11,493
ovarian cancer 10 | 8,520
psoriasis 9 | 6,694
osteosarcoma 8 | 7,950
Breast cancer 7 | 3,578
Cleft Lip 7 | 141
Cleft Palate 7 | 271
Cryptorchidism 7 | 296
Downward slant of palpebral fissure 7 | 158
Orbital separation excessive 7 | 244
group 3 medulloblastoma 7 | 4,104
Autosomal recessive predisposition 6 | 1,442
Breast Neoplasms 6 | 445
Delayed bone age 6 | 136
Depressive disorder 6 | 409
Generalized osteopenia 6 | 99
Hypoplastic mandible condyle 6 | 275
Mammary Neoplasms 6 | 425
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Osteopenia 6 | 99
Short stature 6 | 531
Blepharoptosis 5 | 231
Byzanthine arch palate 5 | 194
Hypogonadism, Isolated Hypogonadotropic 5 | 71
Hypogonadotropic hypogonadism 5 | 89
LADD syndrome 5 | 9
Liver Cirrhosis 5 | 181
Low set ears 5 | 181
Seizures 5 | 596
Strabismus 5 | 270
Telecanthus 5 | 62
Tooth Abnormalities 5 | 69
Wide spaced nipples 5 | 46
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
invasive ductal carcinoma 5 | 2,951
malignant mesothelioma 5 | 3,232
medulloblastoma, large-cell 5 | 6,241
Achondroplasia 4 | 21
Alopecia 4 | 115
Big calvaria 4 | 147
Broad forehead 4 | 59
Carcinoma, Hepatocellular 4 | 228
Cardiac Arrhythmia 4 | 103
Cardiac conduction abnormalities 4 | 78
Concave bridge of nose 4 | 195
Conduction disorder of the heart 4 | 79
Congenital Epicanthus 4 | 177
Congenital pectus carinatum 4 | 52
Decreased projection of midface 4 | 105
Dental abnormalities 4 | 60
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Dull intelligence 4 | 645
EKG abnormalities 4 | 78
Electrocardiogram abnormal 4 | 81
Electrocardiogram change 4 | 78
Epilepsy 4 | 792
Exophthalmos 4 | 112
Feeding difficulties in infancy 4 | 175
Frequent fractures 4 | 53
Frontal bossing 4 | 157
Full lower lip 4 | 64
Hemangioma 4 | 69
High forehead 4 | 102
Hypotrophic midface 4 | 105
Increased fracture rate 4 | 53
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Joint hyperflexibility 4 | 78
Kidney cancer 4 | 2,613
Liver carcinoma 4 | 240
Low-set, posteriorly rotated ears 4 | 110
Lung Neoplasms 4 | 232
Melanocytic nevus 4 | 43
Midface retrusion 4 | 105
Muscle Weakness 4 | 170
Noncancerous mole 4 | 28
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Prominent eyes 4 | 96
Prominent globes 4 | 96
Prominent lower lip 4 | 64
Protruding eyes 4 | 96
Schizophrenia 4 | 1,160
Small midface 4 | 105
Stomach Neoplasms 4 | 300
Tall forehead 4 | 102
Varying degree of multiple fractures 4 | 53
Ventricular Septal Defects 4 | 119
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
subependymal giant cell astrocytoma 4 | 2,287

Tissue

Endocrine System 21 | 18,159
Digestive Tract 20 | 17,369
Nervous System 20 | 16,725
Female tissues 19 | 17,400
Male tissues 19 | 17,142
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678
Blood and immune system 18 | 16,909
Liver and Pancreas 18 | 16,750
Respiratory system 17 | 16,393
Cardiovascular System 15 | 15,192

Target Family

Non-IDG 18 | 12,091
Enzyme 3 | 4,145
Kinase 1 | 634

Reactome Pathway

SHC-mediated cascade:FGFR2 22 | 22
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fibroblast growth factor 22 FGF22 Tbio Non-IDG -1.15836 16.5 186
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.55166 363.0 320
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Fibroblast growth factor 2 FGF2 Tchem Non-IDG -4.00542 10573.5 798
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147
Fibroblast growth factor 3 FGF3 Tbio Non-IDG -2.29270 192.7 118
Fibroblast growth factor 4 FGF4 Tbio Non-IDG -2.60388 394.1 327
Fibroblast growth factor 6 FGF6 Tbio Non-IDG -1.56137 40.2 113
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.07061 109.8 192
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.75464 57.5 162