Development Level

Tbio 9 | 11,445
Tchem 4 | 1,598
Tclin 1 | 613

IMPC Phenotype

abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal head morphology 1 | 10
abnormal locomotor behavior 1 | 24
abnormal startle reflex 1 | 15
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Carcinoma 13 | 11,493
osteosarcoma 10 | 7,950
ovarian cancer 10 | 8,520
glioblastoma 9 | 5,792
medulloblastoma, large-cell 9 | 6,241
atypical teratoid / rhabdoid tumor 8 | 5,112
psoriasis 8 | 6,694
adult high grade glioma 7 | 3,801
Cancer 6 | 2,499
ependymoma 6 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
Breast cancer 5 | 3,578
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung cancer 4 | 4,740
subependymal giant cell astrocytoma 4 | 2,287
Carcinoma, Hepatocellular 3 | 228
Cognitive delay 3 | 608
Dull intelligence 3 | 645
Endometrial cancer 3 | 311
Familial adenomatous polyposis 3 | 32
Global developmental delay 3 | 608
Increased hepatocellular carcinoma risk 3 | 27
Increased incidence of hepatocellular carcinoma 3 | 27
Liver cancer 3 | 604
Liver carcinoma 3 | 240
Low intelligence 3 | 645
Lung Neoplasms 3 | 232
Lymphoid leukemia 3 | 160
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Micronodular cirrhosis 3 | 12
Osteoarthritis 3 | 184
Pick disease 3 | 1,894
Poor school performance 3 | 645
Prostatic Neoplasms 3 | 495
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
Somatic mutation 3 | 61
Stomach Neoplasms 3 | 300
Subacute progressive viral hepatitis 3 | 9
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
hepatocellular carcinoma 3 | 547
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Abdominal Pain 2 | 98
Abnormalities, Multiple 2 | 13
Abnormality of retinal pigmentation 2 | 111
Adenocarcinoma 2 | 122
Adenoma 2 | 167
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Autistic Disorder 2 | 364
Biliary tract cancer 2 | 19
Carcinoma of colon 2 | 32
Colonic Neoplasms 2 | 142
Colorectal Neoplasms 2 | 243
Craniofacial Abnormalities 2 | 151
Dilated ventricles (finding) 2 | 121
Disease Progression 2 | 136
Downward slant of palpebral fissure 2 | 158
ENSP00000256078 2 | 30
Epilepsy 2 | 792
Hypoplasia of corpus callosum 2 | 90
Intestinal Neoplasms 2 | 12
Large intestine cancer 2 | 126
Liver neoplasms 2 | 130
Lynch syndrome 2 | 35
Malabsorption 2 | 82
Melanoma 2 | 711
Muscular atrophy 2 | 71
Neurodevelopmental Disorders 2 | 70
Open mouth 2 | 45
Osteoporosis 2 | 363
Parkinson's disease 2 | 392
Renal Cell Carcinoma 2 | 214
Retinal pigment epithelial abnormality 2 | 111
Seizures 2 | 596
Skin cancer 2 | 469
Stomach cancer 2 | 30
Strabismus 2 | 270
Thyroid cancer 2 | 36
Transitional cell carcinoma of bladder 2 | 17
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,146
gastric carcinoma 2 | 807
lung adenocarcinoma 2 | 2,716
medulloblastoma 2 | 720
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Enzyme 9 | 4,145
Non-IDG 3 | 12,091
Kinase 2 | 634

Reactome Pathway

S45 mutants of beta-catenin ar... 14 | 14
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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