Development Level

Tbio 85 | 10,625
Tchem 30 | 1,890
Tclin 9 | 602
Tdark 3 | 7,003

IMPC Term

preweaning lethality, complete... 14 | 633
embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 3 | 187
abnormal embryo size 2 | 112
decreased body weight 2 | 174
decreased circulating serum al... 2 | 79
decreased mean corpuscular hem... 2 | 34
decreased total body fat amoun... 2 | 186
embryonic growth retardation 2 | 28
increased circulating sodium l... 2 | 71
prenatal lethality prior to he... 2 | 64
abnormal coat/hair pigmentatio... 1 | 54
abnormal craniofacial morpholo... 1 | 12
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal pharyngeal arch morph... 1 | 2
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased lean body mass 1 | 195
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
increased circulating HDL chol... 1 | 63
increased circulating chloride... 1 | 43
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
male infertility 1 | 62
microphthalmia 1 | 15
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 89 | 8,484
psoriasis 70 | 6,685
osteosarcoma 62 | 7,933
lung cancer 61 | 4,466
medulloblastoma, large-cell 57 | 6,234
glioblastoma 55 | 5,572
malignant mesothelioma 51 | 3,162
non-small cell lung cancer 44 | 2,798
primitive neuroectodermal tumor 43 | 3,031
Cancer 41 | 2,346
group 3 medulloblastoma 38 | 2,254
Breast cancer 37 | 3,094
Multiple myeloma 36 | 1,327
pediatric high grade glioma 36 | 2,712
adrenocortical carcinoma 31 | 1,427
atypical teratoid / rhabdoid tumor 31 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,289
lung adenocarcinoma 28 | 2,713
invasive ductal carcinoma 23 | 2,950
nasopharyngeal carcinoma 23 | 1,056
oligodendroglioma 23 | 2,849
Waldenstrons macroglobulinemia 22 | 765
astrocytoma 18 | 1,493
ductal carcinoma in situ 18 | 1,745
posterior fossa group A ependymoma 18 | 1,511
colon cancer 17 | 1,475
dermatomyositis 17 | 933
HIV Infections 16 | 100
pilocytic astrocytoma 16 | 3,086
atypical teratoid/rhabdoid tumor 15 | 1,095
Endometriosis 12 | 535
medulloblastoma 12 | 1,524
subependymal giant cell astrocytoma 12 | 2,287
Carcinoma 11 | 2,147
astrocytic glioma 11 | 2,241
diabetes mellitus 11 | 1,663
ependymoma 11 | 2,514
sonic hedgehog group medulloblastoma 11 | 1,482
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
juvenile dermatomyositis 10 | 1,189
non primary Sjogren syndrome sicca 10 | 840
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
Atopic dermatitis 9 | 944
Pick disease 9 | 1,893
acute quadriplegic myopathy 9 | 1,157
pituitary cancer 9 | 1,972
primary Sjogren syndrome 9 | 789
Bladder Neoplasm 8 | 109
Seckel syndrome 8 | 34
acute myeloid leukemia 8 | 780
breast carcinoma 8 | 1,614
lung carcinoma 8 | 2,844
pancreatic cancer 8 | 2,300
tuberculosis 8 | 1,557
ulcerative colitis 8 | 2,087
IGA Glomerulonephritis 7 | 454
Liver carcinoma 7 | 217
Meier-Gorlin syndrome 7 | 12
Rheumatoid Arthritis 7 | 1,160
active Crohn's disease 7 | 918
esophageal adenocarcinoma 7 | 737
primary pancreatic ductal adenocarcinoma 7 | 1,271
Animal Mammary Neoplasms 6 | 136
Colonic Neoplasms 6 | 126
Cornelia de Lange syndrome 6 | 21
Mammary Neoplasms, Experimental 6 | 150
adult high grade glioma 6 | 2,148
interstitial cystitis 6 | 2,299
Adenoma 5 | 165
Colorectal Neoplasms 5 | 217
EAR, PATELLA, SHORT STATURE SYNDROME 5 | 6
Intellectual disability 5 | 573
Lung Neoplasms 5 | 171
Mantle cell lymphoma 5 | 18
Peripheral Neuropathy 5 | 303
Roberts syndrome 5 | 16
Squamous cell carcinoma of esophagus 5 | 82
Stomach Neoplasms 5 | 282
cystic fibrosis 5 | 1,665
group 4 medulloblastoma 5 | 1,875
inflammatory breast cancer 5 | 404
progressive supranuclear palsy 5 | 674
Alzheimer's disease 4 | 644
Chronic Lymphocytic Leukemia 4 | 242
Cockayne syndrome 4 | 54
Familial adenomatous polyposis 4 | 31
Mammary Neoplasms 4 | 410
Myeloid Leukemia 4 | 19
Prostatic Neoplasms 4 | 471
Xeroderma pigmentosum 4 | 41
cutaneous lupus erythematosus 4 | 1,056
gastric carcinoma 4 | 832
non-small cell lung carcinoma 4 | 413
ovarian neoplasm 4 | 97
Adenoid Cystic Carcinoma 3 | 99
Parkinson's disease 3 | 364
Polycystic Ovary Syndrome 3 | 332
glioblastoma multiforme 3 | 347
tuberculosis and treatment for 6 months 3 | 686

Tissue

Blood and immune system 127 | 17,995
Digestive Tract 127 | 18,473
Endocrine System 127 | 18,512
Female tissues 127 | 18,647
Liver and Pancreas 127 | 18,136
Male tissues 127 | 17,969
Nervous System 127 | 18,561
Urinary Tract 127 | 18,444
Cardiovascular System 126 | 17,958
Respiratory system 126 | 17,484
Skin and soft tissues 126 | 18,115

Target Family

Enzyme 65 | 4,146
Non-IDG 55 | 11,971
Kinase 5 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

S Phase 127 | 127
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.40675 26.5 184
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150