Development Level

Tbio 124 | 11,445
Tchem 18 | 1,598
Tclin 10 | 613
Tdark 8 | 6,588

IMPC Phenotype

preweaning lethality, complete... 22 | 979
embryonic lethality prior to o... 10 | 239
abnormal embryo size 8 | 220
embryonic lethality prior to t... 7 | 278
embryonic growth retardation 6 | 106
preweaning lethality, incomple... 4 | 499
abnormal heart morphology 3 | 162
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
increased mean corpuscular vol... 3 | 92
abnormal craniofacial morpholo... 2 | 33
abnormal placenta size 2 | 20
anophthalmia 2 | 33
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased total body fat amoun... 2 | 207
edema 2 | 59
enlarged heart 2 | 210
female infertility 2 | 60
increased circulating choleste... 2 | 66
male infertility 2 | 123
microphthalmia 2 | 26
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal forebrain morphology 1 | 10
abnormal glucose homeostasis 1 | 4
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal placenta morphology 1 | 5
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
brachydactyly 1 | 19
decreased bone mineral content 1 | 151
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
pallor 1 | 34
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small seminal vesicle 1 | 10
small testis 1 | 58
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

ovarian cancer 111 | 8,520
Carcinoma 85 | 11,493
psoriasis 80 | 6,694
osteosarcoma 78 | 7,950
lung cancer 70 | 4,740
glioblastoma 68 | 5,792
medulloblastoma, large-cell 68 | 6,241
group 3 medulloblastoma 62 | 4,104
malignant mesothelioma 57 | 3,232
Cancer 54 | 2,499
atypical teratoid / rhabdoid tumor 50 | 5,112
non-small cell lung cancer 48 | 2,890
Breast cancer 47 | 3,578
primitive neuroectodermal tumor 46 | 3,035
Multiple myeloma 37 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
adrenocortical carcinoma 35 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,989
ependymoma 34 | 4,679
adult high grade glioma 33 | 3,801
lung adenocarcinoma 32 | 2,716
invasive ductal carcinoma 28 | 2,951
oligodendroglioma 27 | 2,850
nasopharyngeal carcinoma 25 | 1,058
Waldenstrons macroglobulinemia 24 | 765
Kidney cancer 21 | 2,613
astrocytoma 20 | 1,146
colon cancer 20 | 1,478
ductal carcinoma in situ 20 | 1,745
dermatomyositis 19 | 966
Astrocytoma, Pilocytic 17 | 3,081
HIV Infections 16 | 102
diabetes mellitus 16 | 1,728
subependymal giant cell astrocytoma 16 | 2,287
Pick disease 15 | 1,894
astrocytic glioma 15 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
non primary Sjogren syndrome sicca 14 | 891
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Endometriosis 13 | 540
pediatric high grade glioma 13 | 1,064
Intellectual disability 12 | 1,016
acute quadriplegic myopathy 12 | 1,158
tuberculosis 12 | 2,010
Atopic dermatitis 11 | 952
Autosomal recessive predisposition 11 | 1,442
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Small head 11 | 374
acute myeloid leukemia 11 | 783
juvenile dermatomyositis 11 | 1,187
active Crohn's disease 10 | 922
group 4 medulloblastoma 10 | 1,855
lung carcinoma 10 | 2,843
pancreatic cancer 10 | 2,398
pituitary cancer 10 | 1,972
primary Sjogren syndrome 10 | 735
ulcerative colitis 10 | 1,819
Carcinoma, Hepatocellular 9 | 228
Fetal Growth Retardation 9 | 189
Infant, Small for Gestational Age 9 | 176
Intrauterine retardation 9 | 176
Liver carcinoma 9 | 240
Rheumatoid arthritis 9 | 1,191
breast carcinoma 9 | 1,638
Bladder Neoplasm 8 | 112
Cryptorchidism 8 | 296
Dull intelligence 8 | 645
Failure to gain weight 8 | 365
Liver Cirrhosis, Experimental 8 | 769
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Pediatric failure to thrive 8 | 365
Poor school performance 8 | 645
Seckel syndrome 8 | 34
Short stature 8 | 531
Urinary Bladder Neoplasms 8 | 114
esophageal adenocarcinoma 8 | 737
Breast Neoplasms 7 | 445
Cognitive delay 7 | 608
Delayed bone age 7 | 136
Global developmental delay 7 | 608
Mammary Neoplasms 7 | 425
Meier-Gorlin syndrome 7 | 10
Mental and motor retardation 7 | 608
primary pancreatic ductal adenocarcinoma 7 | 1,109
Alzheimer's disease 6 | 658
Bilateral fifth finger clinodactyly 6 | 110
Cockayne syndrome 6 | 60
Colonic Neoplasms 6 | 142
Curvature of little finger 6 | 110
Gastroesophageal reflux disease 6 | 110
Heartburn 6 | 78
Lung Neoplasms 6 | 232
Osteoporosis 6 | 363
cystic fibrosis 6 | 1,696
interstitial cystitis 6 | 2,312
medulloblastoma 6 | 720

Tissue

Endocrine System 159 | 18,159
Blood and immune system 158 | 16,909
Digestive Tract 158 | 17,369
Female tissues 158 | 17,400
Male tissues 158 | 17,142
Nervous System 158 | 16,725
Respiratory system 158 | 16,393
Urinary Tract 158 | 16,678
Cardiovascular System 157 | 15,192
Liver and Pancreas 157 | 16,750
Skin and soft tissues 157 | 17,230

Target Family

Enzyme 76 | 4,145
Non-IDG 69 | 12,091
Kinase 8 | 634
Transcription Factor 7 | 1,400

Reactome Pathway

S Phase 160 | 160
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Anaphase-promoting complex subunit 7 ANAPC7 Tbio Enzyme -0.17118 1.40 73
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
N-acetyltransferase ESCO1 ESCO1 Tbio Enzyme -1.65145 44.6 49
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200