Development Level

Tbio 85 | 10,625
Tchem 29 | 1,890
Tclin 9 | 602
Tdark 3 | 7,003

IMPC Phenotype

preweaning lethality, complete... 14 | 633
embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 3 | 187
abnormal embryo size 2 | 112
decreased body weight 2 | 174
decreased circulating serum al... 2 | 79
decreased mean corpuscular hem... 2 | 34
decreased total body fat amoun... 2 | 186
embryonic growth retardation 2 | 28
increased circulating sodium l... 2 | 71
prenatal lethality prior to he... 2 | 64
abnormal coat-hair pigmentatio... 1 | 54
abnormal craniofacial morpholo... 1 | 12
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal pharyngeal arch morph... 1 | 2
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased lean body mass 1 | 195
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
increased circulating HDL chol... 1 | 63
increased circulating chloride... 1 | 43
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
male infertility 1 | 62
microphthalmia 1 | 15
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 88 | 8,491
psoriasis 70 | 6,685
osteosarcoma 62 | 7,933
lung cancer 61 | 4,473
medulloblastoma, large-cell 57 | 6,234
glioblastoma 55 | 5,572
malignant mesothelioma 51 | 3,163
non-small cell lung cancer 44 | 2,798
primitive neuroectodermal tumor 43 | 3,031
Cancer 41 | 2,346
group 3 medulloblastoma 38 | 2,254
Breast cancer 36 | 3,098
pediatric high grade glioma 36 | 2,712
Multiple myeloma 35 | 1,327
adrenocortical carcinoma 31 | 1,427
atypical teratoid / rhabdoid tumor 31 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,289
lung adenocarcinoma 28 | 2,714
invasive ductal carcinoma 23 | 2,950
nasopharyngeal carcinoma 23 | 1,056
oligodendroglioma 23 | 2,849
Waldenstrons macroglobulinemia 21 | 764
astrocytoma 18 | 1,493
ductal carcinoma in situ 18 | 1,745
posterior fossa group A ependymoma 18 | 1,511
colon cancer 17 | 1,475
dermatomyositis 16 | 966
pilocytic astrocytoma 16 | 3,086
HIV Infections 15 | 99
atypical teratoid/rhabdoid tumor 15 | 1,095
Endometriosis 12 | 535
medulloblastoma 12 | 1,524
subependymal giant cell astrocytoma 12 | 2,287
Carcinoma 11 | 2,147
astrocytic glioma 11 | 2,241
diabetes mellitus 11 | 1,663
ependymoma 11 | 2,514
sonic hedgehog group medulloblastoma 11 | 1,482
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
juvenile dermatomyositis 10 | 1,189
non primary Sjogren syndrome sicca 10 | 840
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
Atopic dermatitis 9 | 944
Pick disease 9 | 1,893
acute myeloid leukemia 9 | 785
acute quadriplegic myopathy 9 | 1,157
pituitary cancer 9 | 1,972
Bladder Neoplasm 8 | 109
Seckel syndrome 8 | 35
breast carcinoma 8 | 1,614
lung carcinoma 8 | 2,844
pancreatic cancer 8 | 2,300
primary Sjogren syndrome 8 | 788
tuberculosis 8 | 1,563
ulcerative colitis 8 | 2,087
IGA Glomerulonephritis 7 | 454
Liver carcinoma 7 | 217
Meier-Gorlin syndrome 7 | 12
active Crohn's disease 7 | 918
esophageal adenocarcinoma 7 | 737
primary pancreatic ductal adenocarcinoma 7 | 1,271
Colonic Neoplasms 6 | 126
Cornelia de Lange syndrome 6 | 21
Mantle cell lymphoma 6 | 20
Rheumatoid Arthritis 6 | 1,170
adult high grade glioma 6 | 2,148
interstitial cystitis 6 | 2,299
Adenoma 5 | 165
Animal Mammary Neoplasms 5 | 135
Colorectal Neoplasms 5 | 217
EAR, PATELLA, SHORT STATURE SYNDROME 5 | 6
Intellectual disability 5 | 573
Lung Neoplasms 5 | 171
Mammary Neoplasms, Experimental 5 | 149
Peripheral Neuropathy 5 | 303
Roberts syndrome 5 | 16
Squamous cell carcinoma of esophagus 5 | 82
Stomach Neoplasms 5 | 282
cystic fibrosis 5 | 1,670
group 4 medulloblastoma 5 | 1,875
inflammatory breast cancer 5 | 404
progressive supranuclear palsy 5 | 674
Alzheimer's disease 4 | 644
Cockayne syndrome 4 | 54
Familial adenomatous polyposis 4 | 33
Kidney cancer 4 | 121
Mammary Neoplasms 4 | 410
Myeloid Leukemia 4 | 19
Prostatic Neoplasms 4 | 471
Xeroderma pigmentosum 4 | 41
chronic lymphocytic leukemia 4 | 244
cutaneous lupus erythematosus 4 | 1,056
gastric carcinoma 4 | 832
non-small cell lung carcinoma 4 | 413
ovarian neoplasm 4 | 97
Parkinson's disease 3 | 364
glioblastoma multiforme 3 | 347
hepatocellular carcinoma 3 | 550
tuberculosis and treatment for 6 months 3 | 686

Tissue

Blood and immune system 126 | 17,994
Digestive Tract 126 | 18,472
Endocrine System 126 | 18,511
Female tissues 126 | 18,646
Liver and Pancreas 126 | 18,135
Male tissues 126 | 17,968
Nervous System 126 | 18,560
Urinary Tract 126 | 18,443
Cardiovascular System 125 | 17,957
Respiratory system 125 | 17,483
Skin and soft tissues 125 | 18,114

Target Family

Enzyme 64 | 4,146
Non-IDG 55 | 11,969
Kinase 5 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

S Phase 126 | 126
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fizzy-related protein homolog FZR1 Tbio Non-IDG -1.77039 58.7 182
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Flap endonuclease 1 FEN1 Tchem Enzyme -2.77484 533.8 332
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.17097 167.1 320
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162
M-phase inducer phosphatase 1 CDC25A Tchem Enzyme -2.45436 266.0 1243
M-phase inducer phosphatase 2 CDC25B Tchem Enzyme -2.31154 209.2 666
DNA polymerase epsilon subunit 3 POLE3 Tbio Enzyme -0.73319 5.86 173