Development Level

Tdark 70 | 6,593
Tbio 16 | 11,651
Tchem 12 | 1,388
Tclin 3 | 612

IMPC Phenotype

decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
increased total body fat amoun... 2 | 134
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating creatini... 1 | 38
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased red blood cell distr... 1 | 34
male infertility 1 | 123
small epididymis 1 | 3
thrombocytopenia 1 | 56

Disease

osteosarcoma 24 | 7,950
psoriasis 21 | 6,694
Carcinoma 19 | 11,493
lung cancer 18 | 4,740
interstitial cystitis 16 | 2,312
lung adenocarcinoma 13 | 2,716
ovarian cancer 13 | 8,520
tuberculosis 13 | 2,010
Cancer 12 | 2,499
ulcerative colitis 12 | 1,819
periodontitis 11 | 293
Autosomal recessive predisposition 10 | 1,442
medulloblastoma, large-cell 10 | 6,241
non-small cell lung cancer 10 | 2,890
lung carcinoma 9 | 2,843
pancreatic cancer 9 | 2,398
Astrocytoma, Pilocytic 8 | 3,081
Breast cancer 8 | 3,578
Multiple myeloma 8 | 1,332
chronic lymphosyte leukemia 8 | 204
glioblastoma 8 | 5,792
Kidney cancer 7 | 2,613
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
Rheumatoid arthritis 6 | 1,191
adult high grade glioma 6 | 3,801
atypical teratoid / rhabdoid tumor 6 | 5,112
cutaneous lupus erythematosus 6 | 1,057
ependymoma 6 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
invasive ductal carcinoma 6 | 2,951
oligodendroglioma 6 | 2,850
Immunologic Deficiency Syndromes 5 | 113
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
cystic fibrosis 5 | 1,696
cystic fibrosis and chronic rhinosinusitis 5 | 214
mucosa-associated lymphoid tissue lymphoma 5 | 484
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Chronic obstructive pulmonary disease 4 | 184
Cognitive delay 4 | 608
Frontal bossing 4 | 157
Global developmental delay 4 | 608
Infantile onset 4 | 238
Leukemia 4 | 104
Liver Cirrhosis, Experimental 4 | 769
Mental and motor retardation 4 | 608
Schizophrenia 4 | 1,160
Seizures 4 | 596
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
malignant mesothelioma 4 | 3,232
non-small cell lung carcinoma 4 | 317
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 735
Agammaglobulinemia 3 | 34
Amebiasis 3 | 21
Arthralgia 3 | 90
Arthritis 3 | 290
Asthma 3 | 385
Bipolar Disorder 3 | 666
Cardiomegaly 3 | 116
Cerebellar Ataxia 3 | 304
DOID:2627 3 | 94
Dull intelligence 3 | 645
Endometrial cancer 3 | 311
Epilepsy 3 | 792
Hypersensitivity reaction type II disease 3 | 253
Hypoplastic mandible condyle 3 | 275
Intellectual disability 3 | 1,016
Isolated growth hormone deficiency 3 | 30
Liver cancer 3 | 604
Low intelligence 3 | 645
Lymphoma 3 | 81
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Muscle hypotonia 3 | 571
Myositis 3 | 30
Poor school performance 3 | 645
Recurrent respiratory infections 3 | 141
Waldenstrons macroglobulinemia 3 | 765
astrocytic glioma 3 | 2,597
diabetes mellitus 3 | 1,728
esophageal adenocarcinoma 3 | 737
nasopharyngeal carcinoma 3 | 1,058
sonic hedgehog group medulloblastoma 3 | 467
spina bifida 3 | 1,074
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Failure to gain weight 2 | 365
Hepatomegaly 2 | 285
Kidney disease 2 | 430
Pediatric failure to thrive 2 | 365
Vasculitis 2 | 80
Ventricular Septal Defects 2 | 119

Tissue

Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678

Target Family

Non-IDG 82 | 12,091
Enzyme 10 | 4,145
Kinase 6 | 634
Ion Channel 3 | 344

Reactome Pathway

Role of phospholipids in phago... 101 | 101
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
High affinity immunoglobulin gamma Fc receptor I FCGR1A Tchem Non-IDG -3.02076 1057.2 766
Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A Tbio Non-IDG -2.88982 811.5 841
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 PLCG1 Tchem Enzyme -2.90339 786.2 846
Phospholipid phosphatase 4 PLPP4 Tbio Enzyme -0.40971 2.39 73
Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 Tbio Enzyme -1.80666 60.0 432
Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A Tbio Non-IDG -3.25185 1691.5 1252
Immunoglobulin heavy variable 4-59 IGHV4-59 Tdark Non-IDG 0.00000 0