Development Level

Tdark 57 | 7,003
Tchem 16 | 1,890
Tbio 13 | 10,625
Tclin 2 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

decreased body weight 2 | 174
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased mature B cell number 2 | 25
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
decreased B cell number 1 | 30
decreased NK T cell number 1 | 28
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased gamma-delta T cell n... 1 | 16
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean platelet volume 1 | 19
increased red blood cell distr... 1 | 21
male infertility 1 | 62
preweaning lethality, complete... 1 | 633
small epididymis 1 | 3
thrombocytopenia 1 | 46

Disease

osteosarcoma 24 | 7,933
psoriasis 19 | 6,685
lung cancer 18 | 4,466
interstitial cystitis 14 | 2,299
lung adenocarcinoma 13 | 2,713
ovarian cancer 13 | 8,484
Cancer 12 | 2,346
ulcerative colitis 12 | 2,087
medulloblastoma, large-cell 11 | 6,234
tuberculosis 11 | 1,557
periodontitis 10 | 269
lung carcinoma 9 | 2,844
non-small cell lung cancer 9 | 2,798
pancreatic cancer 9 | 2,300
Carcinoma 8 | 2,147
chronic lymphosyte leukemia 8 | 232
glioblastoma 8 | 5,572
pilocytic astrocytoma 8 | 3,086
Multiple myeloma 7 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
Breast cancer 6 | 3,094
Rheumatoid Arthritis 6 | 1,160
atypical teratoid / rhabdoid tumor 6 | 4,369
cutaneous lupus erythematosus 6 | 1,056
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
invasive ductal carcinoma 6 | 2,950
oligodendroglioma 6 | 2,849
primitive neuroectodermal tumor 6 | 3,031
subependymal giant cell astrocytoma 6 | 2,287
Amebiasis 5 | 22
Leukemia 5 | 88
Lymphoma 5 | 56
colon cancer 5 | 1,475
cystic fibrosis and chronic rhinosinusitis 5 | 213
ependymoma 5 | 2,514
primary pancreatic ductal adenocarcinoma 5 | 1,271
adult high grade glioma 4 | 2,148
breast carcinoma 4 | 1,614
cystic fibrosis 4 | 1,665
ductal carcinoma in situ 4 | 1,745
group 4 medulloblastoma 4 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
malignant mesothelioma 4 | 3,162
mucosa-associated lymphoid tissue lymphoma 4 | 480
non-small cell lung carcinoma 4 | 413
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 789
Cardiomegaly 3 | 66
Chronic obstructive pulmonary disease 3 | 146
Kidney cancer 3 | 118
Myositis 3 | 24
Obesity 3 | 616
Waldenstrons macroglobulinemia 3 | 765
astrocytic glioma 3 | 2,241
atypical teratoid/rhabdoid tumor 3 | 1,095
diabetes mellitus 3 | 1,663
esophageal adenocarcinoma 3 | 737
group 3 medulloblastoma 3 | 2,254
medulloblastoma 3 | 1,524
nasopharyngeal carcinoma 3 | 1,056
sonic hedgehog group medulloblastoma 3 | 1,482
spina bifida 3 | 1,064
Actinic keratosis 2 | 22
Alzheimer's disease 2 | 644
Arthritis 2 | 248
Asthma 2 | 349
Brain Hypoxia 2 | 2
Cherubism 2 | 14
Colorectal Neoplasms 2 | 217
Diabetes Mellitus, Experimental 2 | 106
Diffuse large B-cell lymphoma 2 | 41
Endometrial cancer 2 | 25
Human immunodeficiency virus infectious disease 2 | 92
Hypersensitivity reaction type II disease 2 | 235
IGA Glomerulonephritis 2 | 454
Kappa-Chain Deficiency 2 | 2
Lupus Erythematosus, Systemic 2 | 73
Malignant neoplasm of breast 2 | 63
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome 2 | 4
Melanoma 2 | 261
Multiple Sclerosis 2 | 498
Neurodegenerative disease 2 | 383
Parkinson's disease 2 | 364
Peripheral Neuropathy 2 | 303
Pick disease 2 | 1,893
Primary immunodeficiency disease 2 | 52
Prostatic Neoplasms 2 | 471
Thrombocytopenia 2 | 105
Vasculitis 2 | 64
acute myeloid leukemia 2 | 780
dermatomyositis 2 | 933
inflammatory breast cancer 2 | 404
juvenile dermatomyositis 2 | 1,189
pancreatic carcinoma 2 | 567
pediatric high grade glioma 2 | 2,712
systemic lupus erythematosus 2 | 156
Growth Disorders 1 | 33
Lymphoma, T-Cell, Cutaneous 1 | 21
Sezary Syndrome 1 | 26
Syndactyly 1 | 56

Tissue

Blood and immune system 73 | 17,995
Digestive Tract 73 | 18,473
Female tissues 73 | 18,647
Respiratory system 73 | 17,484
Skin and soft tissues 73 | 18,115
Liver and Pancreas 72 | 18,136
Urinary Tract 72 | 18,444
Cardiovascular System 70 | 17,958
Endocrine System 69 | 18,512
Nervous System 69 | 18,561
Male tissues 67 | 17,969

Target Family

Non-IDG 68 | 11,971
Enzyme 11 | 4,146
Kinase 6 | 634
Ion Channel 3 | 341

Reactome Pathway

Role of phospholipids in phago... 88 | 88
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Ig lambda-7 chain C region IGLC7 Tdark Non-IDG 228.7 0
Immunoglobulin lambda variable 1-44 IGLV1-44 Tdark Non-IDG 0.00000 0
High affinity immunoglobulin gamma Fc receptor I FCGR1A Tchem Non-IDG -2.98035 1006.3 583
Immunoglobulin heavy variable 1-2 IGHV1-2 Tdark Non-IDG 0.00000 0
Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A Tbio Non-IDG -2.87960 775.0 717
Immunoglobulin kappa variable 3-15 IGKV3-15 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 2-28 IGKV2-28 Tdark Non-IDG 0.00000 0