Development Level

Tbio 70 | 10,625
Tdark 58 | 7,003
Tchem 39 | 1,890
Tclin 24 | 602

Collection

Kinase: IDG Consortium (Targets) 3 | 125
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 10 | 633
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased body weight 4 | 174
decreased bone mineral content 3 | 157
decreased kidney weight 3 | 7
decreased lean body mass 3 | 195
enlarged heart 3 | 111
increased mean corpuscular hem... 3 | 93
abnormal behavior 2 | 226
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating creatini... 2 | 31
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
decreased total body fat amoun... 2 | 186
impaired pupillary reflex 2 | 14
increased circulating LDL chol... 2 | 15
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal glucose homeostasis 1 | 5
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal motor learning 1 | 4
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal vasculature m... 1 | 15
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
absent startle reflex 1 | 15
cataract 1 | 26
cleft palate 1 | 6
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased leukocyte cell numbe... 1 | 54
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hyperactivity 1 | 108
hypoactivity 1 | 89
immune system phenotype 1 | 17
impaired righting response 1 | 19
increased CD4-positive, alpha ... 1 | 15
increased blood urea nitrogen ... 1 | 44
increased cardiac stroke volum... 1 | 1
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
male infertility 1 | 62
mydriasis 1 | 9
narrow eye opening 1 | 15
no spontaneous movement 1 | 1
prenatal lethality prior to he... 1 | 64
prolonged QRS complex duration 1 | 2
small testis 1 | 37
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

osteosarcoma 88 | 7,933
Cancer 81 | 2,346
ovarian cancer 70 | 8,491
psoriasis 68 | 6,685
medulloblastoma, large-cell 59 | 6,234
lung cancer 57 | 4,473
glioblastoma 52 | 5,572
Breast cancer 43 | 3,098
interstitial cystitis 41 | 2,299
invasive ductal carcinoma 40 | 2,950
atypical teratoid / rhabdoid tumor 39 | 4,369
ulcerative colitis 37 | 2,087
non-small cell lung cancer 34 | 2,798
subependymal giant cell astrocytoma 34 | 2,287
diabetes mellitus 33 | 1,663
lung adenocarcinoma 32 | 2,714
malignant mesothelioma 32 | 3,163
Carcinoma 31 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,289
pancreatic cancer 28 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
oligodendroglioma 27 | 2,849
tuberculosis 27 | 1,563
pituitary cancer 26 | 1,972
pediatric high grade glioma 25 | 2,712
ependymoma 24 | 2,514
lung carcinoma 24 | 2,844
pilocytic astrocytoma 24 | 3,086
ductal carcinoma in situ 23 | 1,745
cutaneous lupus erythematosus 22 | 1,056
group 3 medulloblastoma 22 | 2,254
Mammary Neoplasms 21 | 410
Prostatic Neoplasms 21 | 471
breast carcinoma 21 | 1,614
cystic fibrosis 21 | 1,670
group 4 medulloblastoma 21 | 1,875
Rheumatoid Arthritis 20 | 1,170
astrocytic glioma 19 | 2,241
Multiple myeloma 18 | 1,327
Pick disease 18 | 1,893
juvenile dermatomyositis 18 | 1,189
Alzheimer's disease 17 | 644
adult high grade glioma 17 | 2,148
colon cancer 17 | 1,475
Lung Neoplasms 16 | 171
Schizophrenia 16 | 503
primary Sjogren syndrome 16 | 788
primary pancreatic ductal adenocarcinoma 16 | 1,271
primitive neuroectodermal tumor 16 | 3,031
Liver carcinoma 15 | 217
Vascular disease 15 | 281
astrocytoma 15 | 1,493
medulloblastoma 15 | 1,524
Kidney disease 14 | 397
Obesity 14 | 616
Stomach Neoplasms 14 | 282
adrenocortical carcinoma 14 | 1,427
non-small cell lung carcinoma 14 | 413
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Renal Cell Carcinoma 13 | 199
spina bifida 13 | 1,064
Asthma 12 | 349
Cleft palate 12 | 125
Polycystic Ovary Syndrome 12 | 334
fibroadenoma 12 | 557
Neoplasm Invasiveness 11 | 127
Parkinson's disease 11 | 364
atypical teratoid/rhabdoid tumor 11 | 1,095
gastric carcinoma 11 | 832
nasopharyngeal carcinoma 11 | 1,056
ovarian neoplasm 11 | 97
pancreatic carcinoma 11 | 567
periodontitis 11 | 269
Adenoma 10 | 165
Kidney cancer 10 | 121
Squamous cell carcinoma 10 | 96
acute quadriplegic myopathy 10 | 1,157
tuberculosis and treatment for 6 months 10 | 686
Adenocarcinoma 9 | 115
Cleft Lip 9 | 91
Down syndrome 9 | 548
Insulin Resistance 9 | 50
Leukemia 9 | 88
Neoplasm Metastasis 9 | 138
chronic lymphosyte leukemia 9 | 232
esophageal adenocarcinoma 9 | 737
hepatocellular carcinoma 9 | 550
posterior fossa group A ependymoma 9 | 1,511
posterior fossa group B ependymoma 9 | 1,530
Arthritis 8 | 248
Craniosynostosis 8 | 47
Heart disease 8 | 279
Intellectual disability 8 | 573
Reperfusion Injury 8 | 84
Waldenstrons macroglobulinemia 8 | 764
dermatomyositis 8 | 966
gastric cancer 8 | 436
mucosa-associated lymphoid tissue lymphoma 8 | 480
progressive supranuclear palsy 8 | 674

Tissue

Female tissues 177 | 18,646
Digestive Tract 176 | 18,472
Skin and soft tissues 176 | 18,114
Blood and immune system 175 | 17,994
Liver and Pancreas 175 | 18,135
Urinary Tract 175 | 18,443
Endocrine System 173 | 18,511
Nervous System 173 | 18,560
Cardiovascular System 172 | 17,957
Respiratory system 170 | 17,483
Male tissues 168 | 17,968

Target Family

Non-IDG 120 | 11,969
Kinase 40 | 634
Enzyme 25 | 4,146
Transcription Factor 5 | 1,400
Nuclear Receptor 1 | 48

Reactome Pathway

Role of LAT2/NTAL/LAB on calci... 191 | 191
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Trinucleotide repeat-containing gene 6B protein TNRC6B Tbio Non-IDG -0.97375 6.84 59
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Hepatocyte growth factor HGF Tchem Enzyme -3.29371 2317.3 573
Proto-oncogene vav VAV1 Tchem Non-IDG -2.64007 465.9 479
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -2.99634 1000.8 1343
Platelet-derived growth factor subunit B PDGFB Tchem Non-IDG -3.24522 1684.0 357
Ig lambda-6 chain C region IGLC6 Tdark Non-IDG -1.81183 228.7 0
Beta-klotho KLB Tbio Enzyme -1.95818 69.9 47
Tribbles homolog 3 TRIB3 Tbio Kinase -1.88815 82.8 376