Development Level

Tdark 70 | 6,593
Tbio 7 | 11,651
Tchem 6 | 1,388
Tclin 3 | 612

IMPC Phenotype

decreased circulating creatini... 2 | 39
preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
decreased body weight 1 | 161
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
increased blood urea nitrogen ... 1 | 48
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499
thrombocytopenia 1 | 56

Disease

osteosarcoma 17 | 7,950
psoriasis 14 | 6,694
interstitial cystitis 13 | 2,312
Multiple myeloma 11 | 1,332
lung cancer 11 | 4,740
Cancer 10 | 2,499
Carcinoma 10 | 11,493
ovarian cancer 10 | 8,520
periodontitis 10 | 293
lung adenocarcinoma 9 | 2,716
non-small cell lung cancer 9 | 2,890
tuberculosis 9 | 2,010
ulcerative colitis 9 | 1,819
glioblastoma 8 | 5,792
medulloblastoma, large-cell 8 | 6,241
chronic lymphosyte leukemia 7 | 204
invasive ductal carcinoma 7 | 2,951
pancreatic cancer 7 | 2,398
atypical teratoid / rhabdoid tumor 5 | 5,112
cutaneous lupus erythematosus 5 | 1,057
juvenile dermatomyositis 5 | 1,187
primary pancreatic ductal adenocarcinoma 5 | 1,109
subependymal giant cell astrocytoma 5 | 2,287
Astrocytoma, Pilocytic 4 | 3,081
Breast cancer 4 | 3,578
Leukemia 4 | 104
adult high grade glioma 4 | 3,801
cystic fibrosis and chronic rhinosinusitis 4 | 214
diabetes mellitus 4 | 1,728
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
non-small cell lung carcinoma 4 | 317
primary Sjogren syndrome 4 | 735
Amebiasis 3 | 21
Autosomal recessive predisposition 3 | 1,442
Big calvaria 3 | 147
Chronic Lymphocytic Leukemia 3 | 262
Chronic obstructive pulmonary disease 3 | 184
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Diffuse large B-cell lymphoma 3 | 39
Frontal bossing 3 | 157
High forehead 3 | 102
Hypoplastic mandible condyle 3 | 275
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Isolated growth hormone deficiency 3 | 30
Kidney cancer 3 | 2,613
Lymphoma 3 | 81
Lymphoma, Large B-Cell, Diffuse 3 | 34
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Orbital separation excessive 3 | 244
Schizophrenia 3 | 1,160
Tall forehead 3 | 102
Ventricular Septal Defects 3 | 119
Waldenstrons macroglobulinemia 3 | 765
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
lung carcinoma 3 | 2,843
mucosa-associated lymphoid tissue lymphoma 3 | 484
primitive neuroectodermal tumor 3 | 3,035
Acquired scoliosis 2 | 281
Adenocarcinoma of lung 2 | 142
Allergic hypersensitivity disease 2 | 126
Arthritis 2 | 290
Byzanthine arch palate 2 | 194
Congenital Epicanthus 2 | 177
Curvature of spine 2 | 282
Delayed bone age 2 | 136
Endometrial cancer 2 | 311
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Glaucoma 2 | 239
Hepatomegaly 2 | 285
Joint hyperflexibility 2 | 78
Melanoma 2 | 711
Microstomia 2 | 78
Myopia 2 | 176
Pectus excavatum 2 | 100
Pediatric failure to thrive 2 | 365
Pick disease 2 | 1,894
Polymicrogyria 2 | 48
Seizures 2 | 596
Triangular face 2 | 58
acute myeloid leukemia 2 | 783
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 79 | 12,091
Kinase 6 | 634
Enzyme 1 | 4,145

Reactome Pathway

Role of LAT2/NTAL/LAB on calci... 86 | 86
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.12025 204.9 608
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147
Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 Tbio Enzyme -1.80666 60.0 432
Immunoglobulin heavy constant epsilon IGHE Tclin Non-IDG 0.00000 0
Immunoglobulin heavy variable 4-59 IGHV4-59 Tdark Non-IDG 0.00000 0
Immunoglobulin heavy variable 4-39 IGHV4-39 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa constant IGKC Tbio Non-IDG 0.00000 0