Development Level

Tbio 70 | 10,625
Tdark 58 | 7,003
Tchem 39 | 1,890
Tclin 24 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased body weight 4 | 174
decreased bone mineral content 3 | 157
decreased kidney weight 3 | 7
decreased lean body mass 3 | 195
enlarged heart 3 | 111
increased mean corpuscular hem... 3 | 93
abnormal behavior 2 | 226
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating creatini... 2 | 31
decreased grip strength 2 | 123
decreased lumbar vertebrae num... 2 | 62
decreased total body fat amoun... 2 | 186
impaired pupillary reflex 2 | 14
increased circulating LDL chol... 2 | 15
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal glucose homeostasis 1 | 5
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal motor learning 1 | 4
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal vasculature m... 1 | 15
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
absent startle reflex 1 | 15
cataract 1 | 26
cleft palate 1 | 6
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased leukocyte cell numbe... 1 | 54
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hyperactivity 1 | 108
hypoactivity 1 | 89
immune system phenotype 1 | 17
impaired righting response 1 | 19
increased CD4-positive, alpha ... 1 | 15
increased blood urea nitrogen ... 1 | 44
increased cardiac stroke volum... 1 | 1
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
male infertility 1 | 62
mydriasis 1 | 9
narrow eye opening 1 | 15
no spontaneous movement 1 | 1
prenatal lethality prior to he... 1 | 64
prolonged QRS complex duration 1 | 2
small testis 1 | 37
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

osteosarcoma 88 | 7,933
Cancer 81 | 2,346
ovarian cancer 68 | 8,484
psoriasis 68 | 6,685
medulloblastoma, large-cell 59 | 6,234
lung cancer 57 | 4,466
glioblastoma 52 | 5,572
Breast cancer 43 | 3,094
interstitial cystitis 41 | 2,299
invasive ductal carcinoma 40 | 2,950
atypical teratoid / rhabdoid tumor 39 | 4,369
ulcerative colitis 37 | 2,087
non-small cell lung cancer 34 | 2,798
subependymal giant cell astrocytoma 34 | 2,287
diabetes mellitus 33 | 1,663
lung adenocarcinoma 32 | 2,713
malignant mesothelioma 32 | 3,162
Carcinoma 31 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,289
pancreatic cancer 28 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
oligodendroglioma 27 | 2,849
tuberculosis 27 | 1,557
pituitary cancer 26 | 1,972
pediatric high grade glioma 25 | 2,712
ependymoma 24 | 2,514
lung carcinoma 24 | 2,844
pilocytic astrocytoma 24 | 3,086
ductal carcinoma in situ 23 | 1,745
cutaneous lupus erythematosus 22 | 1,056
group 3 medulloblastoma 22 | 2,254
Mammary Neoplasms 21 | 410
Prostatic Neoplasms 21 | 471
breast carcinoma 21 | 1,614
cystic fibrosis 21 | 1,665
group 4 medulloblastoma 21 | 1,875
Rheumatoid Arthritis 20 | 1,160
astrocytic glioma 19 | 2,241
Multiple myeloma 18 | 1,327
Pick disease 18 | 1,893
juvenile dermatomyositis 18 | 1,189
Alzheimer's disease 17 | 644
adult high grade glioma 17 | 2,148
colon cancer 17 | 1,475
Lung Neoplasms 16 | 171
Schizophrenia 16 | 501
primary Sjogren syndrome 16 | 789
primary pancreatic ductal adenocarcinoma 16 | 1,271
primitive neuroectodermal tumor 16 | 3,031
Liver carcinoma 15 | 217
Vascular disease 15 | 281
astrocytoma 15 | 1,493
medulloblastoma 15 | 1,524
Kidney disease 14 | 396
Obesity 14 | 616
Stomach Neoplasms 14 | 282
adrenocortical carcinoma 14 | 1,427
non-small cell lung carcinoma 14 | 413
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Renal Cell Carcinoma 13 | 199
spina bifida 13 | 1,064
Asthma 12 | 349
Cleft palate 12 | 125
Polycystic Ovary Syndrome 12 | 332
fibroadenoma 12 | 557
Neoplasm Invasiveness 11 | 127
Parkinson's disease 11 | 364
atypical teratoid/rhabdoid tumor 11 | 1,095
gastric carcinoma 11 | 832
nasopharyngeal carcinoma 11 | 1,056
ovarian neoplasm 11 | 97
pancreatic carcinoma 11 | 567
periodontitis 11 | 269
Adenoma 10 | 165
Squamous cell carcinoma 10 | 94
acute quadriplegic myopathy 10 | 1,157
tuberculosis and treatment for 6 months 10 | 686
Adenocarcinoma 9 | 115
Cleft Lip 9 | 91
Down syndrome 9 | 548
Leukemia 9 | 88
Neoplasm Metastasis 9 | 138
chronic lymphosyte leukemia 9 | 232
esophageal adenocarcinoma 9 | 737
posterior fossa group A ependymoma 9 | 1,511
posterior fossa group B ependymoma 9 | 1,530
Arthritis 8 | 248
Bipolar Disorder 8 | 266
Craniosynostosis 8 | 47
Heart disease 8 | 279
Intellectual disability 8 | 573
Kidney cancer 8 | 118
Lung disease 8 | 132
Melanoma 8 | 261
Reperfusion Injury 8 | 84
Waldenstrons macroglobulinemia 8 | 765
dermatomyositis 8 | 933
mucosa-associated lymphoid tissue lymphoma 8 | 480
progressive supranuclear palsy 8 | 674

Tissue

Female tissues 177 | 18,647
Digestive Tract 176 | 18,473
Skin and soft tissues 176 | 18,115
Blood and immune system 175 | 17,995
Liver and Pancreas 175 | 18,136
Urinary Tract 175 | 18,444
Endocrine System 173 | 18,512
Nervous System 173 | 18,561
Cardiovascular System 172 | 17,958
Respiratory system 170 | 17,484
Male tissues 168 | 17,969

Target Family

Non-IDG 120 | 11,971
Kinase 40 | 634
Enzyme 25 | 4,146
Transcription Factor 5 | 1,400
Nuclear Receptor 1 | 48

Reactome Pathway

Role of LAT2/NTAL/LAB on calci... 191 | 191
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Beta-klotho KLB Tbio Enzyme -1.89423 69.9 47
Trinucleotide repeat-containing gene 6A protein TNRC6A Tbio Non-IDG -2.03159 112.3 66
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Ig lambda-7 chain C region IGLC7 Tdark Non-IDG 228.7 0
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.51373 345.1 271