Development Level

Tbio 114 | 11,651
Tdark 20 | 6,593
Tchem 3 | 1,388
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 6 | 499
decreased body weight 3 | 161
hyperactivity 3 | 148
increased circulating alkaline... 3 | 122
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased total body fat amoun... 2 | 207
hypoactivity 2 | 132
increased blood urea nitrogen ... 2 | 48
increased circulating calcium ... 2 | 34
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased startle reflex 2 | 112
microphthalmia 2 | 26
short tibia 2 | 97
abnormal brain morphology 1 | 13
abnormal cranium morphology 1 | 36
abnormal response to tactile s... 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal vibrissa morphology 1 | 25
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hydroencephaly 1 | 14
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 1
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased spleen weight 1 | 10
male infertility 1 | 123
prolonged PQ interval 1 | 5
prolonged PR interval 1 | 15
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 108 | 11,493
osteosarcoma 85 | 7,950
ovarian cancer 79 | 8,520
medulloblastoma, large-cell 68 | 6,241
glioblastoma 67 | 5,792
atypical teratoid / rhabdoid tumor 57 | 5,112
adult high grade glioma 53 | 3,801
psoriasis 53 | 6,694
lung cancer 49 | 4,740
ependymoma 48 | 4,679
group 3 medulloblastoma 48 | 4,104
primitive neuroectodermal tumor 46 | 3,035
Kidney cancer 45 | 2,613
invasive ductal carcinoma 43 | 2,951
non-small cell lung cancer 42 | 2,890
lung carcinoma 40 | 2,843
subependymal giant cell astrocytoma 40 | 2,287
Astrocytoma, Pilocytic 39 | 3,081
Breast cancer 38 | 3,578
lung adenocarcinoma 38 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
oligodendroglioma 33 | 2,850
astrocytic glioma 31 | 2,597
malignant mesothelioma 31 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
group 4 medulloblastoma 29 | 1,855
ulcerative colitis 28 | 1,819
Cancer 26 | 2,499
ductal carcinoma in situ 24 | 1,745
interstitial cystitis 24 | 2,312
Pick disease 23 | 1,894
cystic fibrosis 23 | 1,696
pituitary cancer 23 | 1,972
pancreatic cancer 22 | 2,398
breast carcinoma 21 | 1,638
Intellectual disability 18 | 1,016
acute quadriplegic myopathy 15 | 1,158
spina bifida 15 | 1,074
tuberculosis 15 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
colon cancer 13 | 1,478
cutaneous lupus erythematosus 13 | 1,057
primary Sjogren syndrome 12 | 735
Liver Cirrhosis, Experimental 10 | 769
Schizophrenia 10 | 1,160
aldosterone-producing adenoma 10 | 665
astrocytoma 10 | 1,146
juvenile dermatomyositis 10 | 1,187
pediatric high grade glioma 10 | 1,064
Liver cancer 9 | 604
Rheumatoid arthritis 9 | 1,191
Waldenstrons macroglobulinemia 9 | 765
active Crohn's disease 9 | 922
dermatomyositis 9 | 966
gastric cancer 9 | 459
Amyotrophic lateral sclerosis 8 | 451
Melanoma 8 | 711
Multiple myeloma 8 | 1,332
active ulcerative colitis 8 | 764
fibroadenoma 8 | 559
mucosa-associated lymphoid tissue lymphoma 8 | 484
nasopharyngeal carcinoma 8 | 1,058
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
adrenocortical carcinoma 7 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
diabetes mellitus 7 | 1,728
gastric carcinoma 7 | 807
hepatocellular carcinoma 7 | 547
non primary Sjogren syndrome sicca 7 | 891
primary pancreatic ductal adenocarcinoma 7 | 1,109
progressive supranuclear palsy 7 | 676
Cryptorchidism 6 | 296
Endometriosis 6 | 540
Polycystic ovary syndrome 6 | 360
Skin cancer 6 | 469
esophageal adenocarcinoma 6 | 737
interstitial lung disease 6 | 298
medulloblastoma 6 | 720
pancreatic carcinoma 6 | 562
sonic hedgehog group medulloblastoma 6 | 467
Aarskog syndrome 5 | 12
Alzheimer's disease 5 | 658
Atopic dermatitis 5 | 952
Familial hypocalciuric hypercalcemia 5 | 20
HIV Infections 5 | 102
Prostatic Neoplasms 5 | 495
Short stature 5 | 531
Strabismus 5 | 270
X- linked recessive 5 | 110
sarcoidosis 5 | 370
Chronic Lymphocytic Leukemia 4 | 262
Crohn's disease 4 | 321
Down syndrome 4 | 499
Epilepsy 4 | 792
Type 2 diabetes mellitus 4 | 272

Tissue

Digestive Tract 137 | 17,369
Endocrine System 137 | 18,159
Female tissues 137 | 17,400
Liver and Pancreas 137 | 16,750
Blood and immune system 136 | 16,909
Male tissues 136 | 17,142
Respiratory system 136 | 16,393
Skin and soft tissues 136 | 17,230
Urinary Tract 136 | 16,678
Nervous System 135 | 16,725
Cardiovascular System 131 | 15,192

Target Family

Non-IDG 72 | 12,091
Enzyme 63 | 4,145
Kinase 3 | 634

Reactome Pathway

Rho GTPase cycle 138 | 138
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rho guanine nucleotide exchange factor 38 ARHGEF38 Tdark Non-IDG 0.85 0.14 8
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
Rho GTPase-activating protein 7 DLC1 Tbio Enzyme -1.93185 106.7 137
StAR-related lipid transfer protein 13 STARD13 Tbio Non-IDG -2.03717 75.4 82
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Pleckstrin homology domain-containing family G member 5 PLEKHG5 Tbio Non-IDG -2.19698 161.7 100
Rho-related BTB domain-containing protein 1 RHOBTB1 Tdark Non-IDG -0.74101 4.47 130
SLIT-ROBO Rho GTPase-activating protein 3 SRGAP3 Tbio Enzyme -1.70089 58.5 76
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.20394 172.2 226
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227