Development Level

Tbio 9 | 11,445
Tchem 2 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal seminal vesicle morph... 1 | 114
absent pinna reflex 1 | 23
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hypoactivity 1 | 132
increased circulating free fat... 1 | 20
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
long tibia 1 | 25
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small superior vagus ganglion 1 | 74

Disease

Carcinoma 10 | 11,493
ovarian cancer 8 | 8,520
psoriasis 6 | 6,694
Autosomal recessive predisposition 4 | 1,442
Kidney cancer 4 | 2,613
glioblastoma 4 | 5,792
oligodendroglioma 4 | 2,850
Alzheimer's disease 3 | 658
Astrocytoma, Pilocytic 3 | 3,081
Breast cancer 3 | 3,578
Cataract 8 multiple types 3 | 33
Hyperactive behavior 3 | 91
Intellectual disability 3 | 1,016
Neuropathy 3 | 261
Pick disease 3 | 1,894
Schizophrenia 3 | 1,160
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
lung carcinoma 3 | 2,843
medulloblastoma, large-cell 3 | 6,241
osteosarcoma 3 | 7,950
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Absence of pain sensation 2 | 5
Acral ulceration and osteomyelitis leading to autoamputation 2 | 4
Anhidrosis 2 | 23
Cancer 2 | 2,499
Congenital Pain Insensitivity 2 | 6
Corneal Ulcer 2 | 21
Dull intelligence 2 | 645
Hereditary Sensory Autonomic Neuropathy, Type 5 2 | 5
Hereditary Sensory and Autonomic Neuropathies 2 | 4
Infantile onset 2 | 238
Lewy Body Disease 2 | 21
Low intelligence 2 | 645
Lung Injury 2 | 20
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Multiple Sclerosis 2 | 540
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Neurodegenerative disease 2 | 414
Pain agnosia 2 | 104
Parkinson's disease 2 | 392
Poor school performance 2 | 645
Seizures 2 | 596
Self Mutilation 2 | 14
Skin Ulcer 2 | 48
Toxic encephalopathy 2 | 141
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
interstitial lung disease 2 | 298
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
pituitary cancer 2 | 1,972
Alcohol withdrawal syndrome 1 | 20
Amnesia 1 | 17
Ataxia telangiectasia 1 | 34
Autistic behavior 1 | 20
Autosomal dominant Robinow syndrome 1 1 | 15
Axonal degeneration 1 | 7
Calcium pyrophosphate deposition disease 1 | 13
Centronuclear myopathy 1 | 27
Cloudy cornea 1 | 33
Complex regional pain syndrome 1 | 12
Corneal Scar 1 | 7
Decreased number of small peripheral myelinated nerve fibers 1 | 1
Decreased pain sensation 1 | 17
Diffuse large B-cell lymphoma 1 | 39
Familial medullary thyroid carcinoma 1 | 3
Glomerulonephritis 1 | 46
HSAN Type IV 1 | 1
Hereditary insensitivity to pain with anhidrosis 1 | 1
Hereditary sensory neuropathy 1 | 11
Hyperkinesis 1 | 32
Hypoparathyroidism 1 | 41
Hypotrichosis of the scalp 1 | 6
Infarction, Middle Cerebral Artery 1 | 33
Infection of bone 1 | 19
Inflammatory myofibroblastic tumor 1 | 8
Irritation - emotion 1 | 68
Kidney Failure, Chronic 1 | 46
Lymphoma, Large B-Cell, Diffuse 1 | 34
Medullary carcinoma of thyroid 1 | 2
Neurodegenerative Diseases 1 | 38
Neurogenic arthropathy 1 | 2
Neurotrophic keratitis 1 | 2
Pancreatitis 1 | 123
Papillary thyroid carcinoma 1 | 43
Phaeochromocytoma 1 | 20
Polyneuropathy 1 | 64
Postural hypotension with compensatory tachycardia 1 | 2
Segmental demyelination/remyelination 1 | 8
Self-Injurious Behavior 1 | 12
Spinocerebellar ataxia type 2 1 | 23
Tetanus 1 | 68
Tonic - clonic seizures 1 | 44

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Non-IDG 12 | 12,091
Kinase 1 | 634

Reactome Pathway

Retrograde neurotrophin signal... 13 | 13
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Dynamin-1 DNM1 Tbio Non-IDG -2.67692 450.0 464
Clathrin light chain A CLTA Tbio Non-IDG -1.32676 16.0 244
Dynamin-3 DNM3 Tbio Non-IDG -1.43916 22.6 146
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248
Dynamin-2 DNM2 Tchem Non-IDG -2.43547 282.5 143
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.59767 34.8 212
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.65996 4.74 124