Development Level

Tbio 86 | 11,445
Tchem 12 | 1,598
Tdark 6 | 6,588
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 21 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 4 | 499
decreased circulating choleste... 3 | 93
embryonic growth retardation 3 | 106
increased fasted circulating g... 3 | 76
abnormal behavior 2 | 298
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
abnormal tail morphology 2 | 25
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased heart left ventricle... 2 | 28
decreased total body fat amoun... 2 | 207
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal motor learning 1 | 3
abnormal placenta morphology 1 | 5
abnormal placenta size 1 | 20
abnormal placenta vasculature 1 | 2
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal testis morphology 1 | 43
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small testis 1 | 58
syndactyly 1 | 23
urinary bladder obstruction 1 | 4

Disease

Carcinoma 70 | 11,493
medulloblastoma, large-cell 70 | 6,241
ovarian cancer 69 | 8,520
glioblastoma 64 | 5,792
group 3 medulloblastoma 62 | 4,104
atypical teratoid / rhabdoid tumor 61 | 5,112
lung cancer 55 | 4,740
psoriasis 55 | 6,694
primitive neuroectodermal tumor 53 | 3,035
Breast cancer 51 | 3,578
osteosarcoma 50 | 7,950
non-small cell lung cancer 43 | 2,890
adult high grade glioma 42 | 3,801
adrenocortical carcinoma 41 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
ependymoma 39 | 4,679
malignant mesothelioma 38 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
invasive ductal carcinoma 36 | 2,951
lung adenocarcinoma 33 | 2,716
breast carcinoma 26 | 1,638
ductal carcinoma in situ 26 | 1,745
Kidney cancer 24 | 2,613
Endometriosis 23 | 540
colon cancer 23 | 1,478
oligodendroglioma 23 | 2,850
pancreatic cancer 23 | 2,398
Atopic dermatitis 22 | 952
Cancer 22 | 2,499
nasopharyngeal carcinoma 22 | 1,058
Waldenstrons macroglobulinemia 18 | 765
Multiple myeloma 16 | 1,332
astrocytic glioma 16 | 2,597
Astrocytoma, Pilocytic 15 | 3,081
Intellectual disability 15 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Pick disease 13 | 1,894
dermatomyositis 13 | 966
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
pediatric high grade glioma 12 | 1,064
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Small head 11 | 374
acute quadriplegic myopathy 11 | 1,158
subependymal giant cell astrocytoma 11 | 2,287
ulcerative colitis 11 | 1,819
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Rheumatoid arthritis 10 | 1,191
tuberculosis 10 | 2,010
interstitial cystitis 9 | 2,312
pituitary cancer 9 | 1,972
primary Sjogren syndrome 9 | 735
Hypoplastic mandible condyle 8 | 275
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Short stature 8 | 531
astrocytoma 8 | 1,146
juvenile dermatomyositis 8 | 1,187
Epilepsy 7 | 792
Microcephaly 7 | 166
Seizures 7 | 596
active Crohn's disease 7 | 922
group 4 medulloblastoma 7 | 1,855
Anteverted nostril 6 | 191
Cornelia de Lange syndrome 6 | 21
Dilated ventricles (finding) 6 | 121
Downward slant of palpebral fissure 6 | 158
Lissencephaly 6 | 69
Roberts syndrome 6 | 15
acute myeloid leukemia 6 | 783
gastric carcinoma 6 | 807
hereditary spastic paraplegia 6 | 318
posterior fossa group A ependymoma 6 | 468
Autosomal recessive predisposition 5 | 1,442
Cerebellar Hypoplasia 5 | 61
Fetal Growth Retardation 5 | 189
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Lymphoid leukemia 5 | 160
Orbital separation excessive 5 | 244
Schizophrenia 5 | 1,160
Short neck 5 | 140
Short nose 5 | 132
Small nose 5 | 132
aldosterone-producing adenoma 5 | 665
tuberculosis and treatment for 6 months 5 | 409
Alzheimer's disease 4 | 658
Bilateral fifth finger clinodactyly 4 | 110
Congenital Epicanthus 4 | 177
Delayed bone age 4 | 136
Depressed nasal bridge 4 | 195
Down syndrome 4 | 499
Feeding difficulties in infancy 4 | 175
Glaucoma 4 | 239
lung carcinoma 4 | 2,843

Tissue

Endocrine System 105 | 18,159
Blood and immune system 104 | 16,909
Digestive Tract 104 | 17,369
Female tissues 104 | 17,400
Liver and Pancreas 104 | 16,750
Male tissues 104 | 17,142
Nervous System 104 | 16,725
Respiratory system 104 | 16,393
Skin and soft tissues 104 | 17,230
Urinary Tract 104 | 16,678
Cardiovascular System 101 | 15,192

Target Family

Non-IDG 84 | 12,091
Enzyme 14 | 4,145
Kinase 6 | 634
Epigenetic 1 | 242

Reactome Pathway

Resolution of Sister Chromatid... 105 | 105
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
Spindle and kinetochore-associated protein 2 SKA2 Tbio Non-IDG -1.23206 10.2 108
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Centromere protein K CENPK Tbio Non-IDG -1.21832 16.6 130
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Kinesin-like protein KIF2C KIF2C Tbio Non-IDG -2.12404 136.3 256
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169
Cytoplasmic dynein 1 light intermediate chain 2 DYNC1LI2 Tbio Non-IDG -0.61455 3.87 95