Development Level

Tbio 27 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

embryonic lethality prior to t... 3 | 278
preweaning lethality, complete... 3 | 979
abnormal eye morphology 2 | 68
embryonic lethality prior to o... 2 | 239
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye size 1 | 7
abnormal placement of pupils 1 | 6
abnormal spleen morphology 1 | 55
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
female infertility 1 | 60
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 24 | 11,493
osteosarcoma 22 | 7,950
ovarian cancer 22 | 8,520
Breast cancer 20 | 3,578
Cancer 16 | 2,499
Fanconi anemia 15 | 56
group 3 medulloblastoma 15 | 4,104
lung cancer 15 | 4,740
medulloblastoma, large-cell 15 | 6,241
malignant mesothelioma 14 | 3,232
psoriasis 14 | 6,694
Bloom syndrome 12 | 29
glioblastoma 12 | 5,792
Breast Neoplasms 11 | 445
Hereditary Breast and Ovarian Cancer Syndrome 11 | 14
Mammary Neoplasms 11 | 425
Short stature 11 | 531
atypical teratoid / rhabdoid tumor 11 | 5,112
primitive neuroectodermal tumor 11 | 3,035
Autosomal recessive predisposition 10 | 1,442
Small head 10 | 374
ductal carcinoma in situ 10 | 1,745
invasive ductal carcinoma 10 | 2,951
Dull intelligence 9 | 645
Intellectual disability 9 | 1,016
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
adult high grade glioma 9 | 3,801
colon cancer 9 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
non-small cell lung cancer 9 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
lung adenocarcinoma 8 | 2,716
nasopharyngeal carcinoma 8 | 1,058
Anemia 7 | 365
Chromosome Breakage 7 | 36
Kidney cancer 7 | 2,613
Malignant neoplasm of breast 7 | 15
ependymoma 7 | 4,679
non primary Sjogren syndrome sicca 7 | 891
Ataxia telangiectasia 6 | 34
Cognitive delay 6 | 608
Decreased platelet count 6 | 111
Global developmental delay 6 | 608
Increased chromosomal breakage 6 | 27
Mental and motor retardation 6 | 608
Nijmegen breakage syndrome 6 | 24
Thrombocytopenia 6 | 197
breast carcinoma 6 | 1,638
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 5 | 9
Esophageal atresia with or without tracheoesophageal fistula 5 | 21
Leukopenia 5 | 72
Ovarian Neoplasms 5 | 102
Prostate cancer 5 | 175
Werner syndrome 5 | 29
Xeroderma pigmentosum group F 5 | 22
adrenocortical carcinoma 5 | 1,428
esophageal atresia/tracheoesophageal fistula 5 | 22
hypopigmented skin patch 5 | 59
ovarian neoplasm 5 | 99
Acquired scoliosis 4 | 281
Almond-shaped eyes 4 | 23
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 4 | 13
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2 4 | 8
Breast Cancer, Familial 4 | 8
Convex nasal ridge 4 | 37
Curvature of spine 4 | 282
Fetal Growth Retardation 4 | 189
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Irregular hyperpigmentation 4 | 33
Pyridoxine-responsive sideroblastic anemia 4 | 17
Radial aplasia/hypoplasia 4 | 29
Rothmund-Thomson syndrome 4 | 19
Short palpebral fissure 4 | 38
Tumor Predisposition Syndrome 4 | 6
Xeroderma pigmentosum 4 | 43
Xeroderma pigmentosum group G 4 | 16
astrocytic glioma 4 | 2,597
oligodendroglioma 4 | 2,850
Astrocytoma, Pilocytic 3 | 3,081
Cockayne syndrome 3 | 60
Hypoplastic mandible condyle 3 | 275
Large nose 3 | 23
Liver cancer 3 | 604
Microcephaly 3 | 166
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85
Prostatic Neoplasms 3 | 495
Schizophrenia 3 | 1,160
Seckel syndrome 3 | 34
Xeroderma pigmentosum group D 3 | 33
cutaneous lupus erythematosus 3 | 1,057
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung carcinoma 3 | 2,843
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Cardiovascular System 30 | 15,192
Liver and Pancreas 30 | 16,750

Target Family

Non-IDG 19 | 12,091
Enzyme 11 | 4,145
Epigenetic 1 | 242

Reactome Pathway

Resolution of D-Loop Structure... 31 | 31
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414
Regulator of telomere elongation helicase 1 RTEL1 Tbio Enzyme -2.66156 233.0 85
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
Exonuclease 1 EXO1 Tbio Enzyme -2.64302 437.0 263
Structure-specific endonuclease subunit SLX4 SLX4 Tbio Enzyme -1.68794 61.7 56
DNA repair-scaffolding protein SPIDR Tbio Non-IDG -0.75333 5.57 24
Flap endonuclease GEN homolog 1 GEN1 Tbio Enzyme -2.07325 115.0 76