Development Level

Tbio 24 | 10,625
Tchem 8 | 1,890
Tclin 4 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to o... 3 | 148
polydactyly 2 | 22
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal pharyngeal arch morph... 1 | 2
abnormal retinal inner nuclear... 1 | 5
decreased CD4-positive, CD25-p... 1 | 24
decreased circulating aspartat... 1 | 27
decreased grip strength 1 | 123
decreased leukocyte cell numbe... 1 | 54
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
increased circulating HDL chol... 1 | 63
increased circulating aspartat... 1 | 17
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 21 | 8,484
malignant mesothelioma 18 | 3,162
osteosarcoma 18 | 7,933
group 3 medulloblastoma 17 | 2,254
lung cancer 16 | 4,466
psoriasis 16 | 6,685
medulloblastoma, large-cell 15 | 6,234
Cancer 13 | 2,346
non-small cell lung cancer 12 | 2,798
glioblastoma 11 | 5,572
primitive neuroectodermal tumor 11 | 3,031
Breast cancer 8 | 3,094
Waldenstrons macroglobulinemia 8 | 765
atypical teratoid / rhabdoid tumor 8 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
oligodendroglioma 7 | 2,849
invasive ductal carcinoma 6 | 2,950
nasopharyngeal carcinoma 6 | 1,056
Colorectal Neoplasms 5 | 217
Multiple myeloma 5 | 1,327
Xeroderma pigmentosum 5 | 41
atypical teratoid/rhabdoid tumor 5 | 1,095
diabetes mellitus 5 | 1,663
lung adenocarcinoma 5 | 2,713
tuberculosis 5 | 1,557
Carcinoma 4 | 2,147
Lynch syndrome 4 | 33
Malignant tumor of ovary 4 | 25
Neurodegenerative disease 4 | 383
Peripheral Neuropathy 4 | 303
Prostatic Neoplasms 4 | 471
adrenocortical carcinoma 4 | 1,427
astrocytoma 4 | 1,493
dermatomyositis 4 | 933
ductal carcinoma in situ 4 | 1,745
pediatric high grade glioma 4 | 2,712
subependymal giant cell astrocytoma 4 | 2,287
Adenoma 3 | 165
Cerebrovascular disease 3 | 231
Chronic Lymphocytic Leukemia 3 | 242
Cockayne syndrome 3 | 54
Colorectal adenoma 3 | 15
Familial adenomatous polyposis 3 | 31
Stomach Neoplasms 3 | 282
acute myeloid leukemia 3 | 780
adult high grade glioma 3 | 2,148
astrocytic glioma 3 | 2,241
ependymoma 3 | 2,514
sonic hedgehog group medulloblastoma 3 | 1,482
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 16
Acute promyelocytic leukemia, FAB M3 2 | 10
Adenocarcinoma 2 | 115
Adenocarcinoma of pancreas 2 | 12
Adenomatous Polyposis Coli 2 | 10
Alzheimer's disease 2 | 644
Apraxia 2 | 25
Ataxia telangiectasia 2 | 31
Ataxia with oculomotor apraxia type 1 2 | 5
Atherosclerosis 2 | 275
Bladder Neoplasm 2 | 109
Bloom syndrome 2 | 30
Carcinoma in situ of fallopian tube 2 | 2
Colonic Neoplasms 2 | 126
Endometriosis 2 | 535
Epilepsy 2 | 346
Epithelial tumor of ovary 2 | 3
Heart Diseases 2 | 42
IGA Glomerulonephritis 2 | 454
Intellectual disability 2 | 573
Lipodystrophy 2 | 32
Lung Neoplasms 2 | 171
Lymphomatous meningitis 2 | 3
Malignant epithelial tumor of ovary 2 | 3
Malignant tumor of peritoneum 2 | 4
Melanoma 2 | 261
Meningeal Leukemia 2 | 7
Metastatic Breast Carcinoma 2 | 21
Micronuclei, Chromosome-Defective 2 | 19
Obesity 2 | 616
Parkinson's disease 2 | 364
Pick disease 2 | 1,893
Seckel syndrome 2 | 34
Seizures 2 | 95
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
gastric carcinoma 2 | 832
group 4 medulloblastoma 2 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
juvenile dermatomyositis 2 | 1,189
lung carcinoma 2 | 2,844
non primary Sjogren syndrome sicca 2 | 840
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
primary Sjogren syndrome 2 | 789
spina bifida 2 | 1,064
ulcerative colitis 2 | 2,087
Kidney cancer 1 | 118
Typhoid fever 1 | 22

Tissue

Blood and immune system 37 | 17,995
Cardiovascular System 37 | 17,958
Digestive Tract 37 | 18,473
Endocrine System 37 | 18,512
Female tissues 37 | 18,647
Liver and Pancreas 37 | 18,136
Male tissues 37 | 17,969
Nervous System 37 | 18,561
Respiratory system 37 | 17,484
Skin and soft tissues 37 | 18,115
Urinary Tract 37 | 18,444

Target Family

Enzyme 26 | 4,146
Non-IDG 10 | 11,971
Transcription Factor 1 | 1,400

Reactome Pathway

Resolution of Abasic Sites (AP... 37 | 37
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Single-strand selective monofunctional uracil DNA glycosylase SMUG1 Tbio Enzyme -4.25142 18890.7 165
N-glycosylase/DNA lyase OGG1 Tbio Enzyme -3.23405 1747.3 234
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.40675 26.5 184
DNA ligase 3 LIG3 Tbio Enzyme -2.71696 505.0 223
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.80635 59.3 127