Development Level

Tbio 72 | 11,445
Tdark 22 | 6,588
Tchem 14 | 1,598
Tclin 1 | 613

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

male infertility 9 | 123
female infertility 5 | 60
preweaning lethality, complete... 5 | 979
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
improved glucose tolerance 2 | 79
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
edema 1 | 59
hyperactivity 1 | 148
hypoactivity 1 | 132
increased body temperature 1 | 9
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74

Disease

Carcinoma 66 | 11,493
ovarian cancer 48 | 8,520
psoriasis 45 | 6,694
osteosarcoma 36 | 7,950
lung cancer 34 | 4,740
Breast cancer 32 | 3,578
glioblastoma 31 | 5,792
medulloblastoma, large-cell 31 | 6,241
atypical teratoid / rhabdoid tumor 28 | 5,112
group 3 medulloblastoma 28 | 4,104
malignant mesothelioma 26 | 3,232
Cancer 25 | 2,499
Kidney cancer 24 | 2,613
ependymoma 23 | 4,679
Infertility 19 | 188
Male infertility 19 | 206
primitive neuroectodermal tumor 19 | 3,035
invasive ductal carcinoma 18 | 2,951
lung adenocarcinoma 18 | 2,716
Autosomal recessive predisposition 17 | 1,442
ductal carcinoma in situ 17 | 1,745
adult high grade glioma 16 | 3,801
non-small cell lung cancer 16 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Astrocytoma, Pilocytic 14 | 3,081
Short stature 14 | 531
colon cancer 14 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
oligodendroglioma 14 | 2,850
Intellectual disability 13 | 1,016
Small head 12 | 374
breast carcinoma 12 | 1,638
lung carcinoma 12 | 2,843
pancreatic cancer 12 | 2,398
Dull intelligence 10 | 645
Liver cancer 10 | 604
Low intelligence 10 | 645
Mammary Neoplasms 10 | 425
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Multiple myeloma 10 | 1,332
Poor school performance 10 | 645
cystic fibrosis 10 | 1,696
nasopharyngeal carcinoma 10 | 1,058
Ataxia telangiectasia 9 | 34
Breast Neoplasms 9 | 445
Cognitive delay 9 | 608
Fetal Growth Retardation 9 | 189
Global developmental delay 9 | 608
Infant, Small for Gestational Age 9 | 176
Intrauterine retardation 9 | 176
Melanoma 9 | 711
Mental and motor retardation 9 | 608
Prostatic Neoplasms 9 | 495
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
subependymal giant cell astrocytoma 9 | 2,287
Chromosome Breakage 8 | 36
Endometriosis 8 | 540
Nijmegen breakage syndrome 8 | 24
Pick disease 8 | 1,894
Waldenstrons macroglobulinemia 8 | 765
cutaneous lupus erythematosus 8 | 1,057
pituitary cancer 8 | 1,972
Cryptorchidism 7 | 296
Delayed bone age 7 | 136
Endometrial cancer 7 | 311
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Premature ovarian failure 7 | 65
astrocytoma 7 | 1,146
dermatomyositis 7 | 966
diabetes mellitus 7 | 1,728
Attention deficit hyperactivity disorder 6 | 278
Bilateral fifth finger clinodactyly 6 | 110
Curvature of little finger 6 | 110
Emery-Dreifuss muscular dystrophy 6 | 23
Fanconi anemia 6 | 56
Increased chromosomal breakage 6 | 27
Muscle Hypertonia 6 | 88
Penile hypospadias 6 | 106
Premature Menopause 6 | 31
Werner syndrome 6 | 29
Xeroderma pigmentosum 6 | 43
acute quadriplegic myopathy 6 | 1,158
astrocytic glioma 6 | 2,597
progressive supranuclear palsy 6 | 676
Chronic Lymphocytic Leukemia 5 | 262
Down syndrome 5 | 499
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
adrenocortical carcinoma 5 | 1,428
gastric cancer 5 | 459
interstitial cystitis 5 | 2,312
pancreatic carcinoma 5 | 562
pediatric high grade glioma 5 | 1,064
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819

Tissue

Endocrine System 108 | 18,159
Female tissues 100 | 17,400
Skin and soft tissues 98 | 17,230
Digestive Tract 95 | 17,369
Male tissues 95 | 17,142
Blood and immune system 94 | 16,909
Nervous System 93 | 16,725
Liver and Pancreas 90 | 16,750
Respiratory system 90 | 16,393
Urinary Tract 90 | 16,678
Cardiovascular System 85 | 15,192

Target Family

Non-IDG 84 | 12,091
Enzyme 11 | 4,145
Ion Channel 6 | 344
Kinase 4 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

Reactome Pathway

Reproduction 109 | 109
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meiotic recombination protein SPO11 SPO11 Tbio Non-IDG -2.33263 208.9 148
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
Nesprin-2 SYNE2 Tbio Non-IDG -2.62747 380.6 39
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Cohesin subunit SA-3 STAG3 Tbio Non-IDG -1.30055 20.0 104
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200