Development Level

Tbio 8 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal embryo size 2 | 220
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
anophthalmia 1 | 33
decreased B cell number 1 | 5
decreased body weight 1 | 161
decreased startle reflex 1 | 75
embryonic lethality prior to t... 1 | 278
hyperactivity 1 | 148
hypoactivity 1 | 132
increased circulating potassiu... 1 | 29
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 5 | 11,493
Visceral heterotaxy 5 | 14
ovarian cancer 5 | 8,520
Right atrial isomerism 4 | 29
Situs ambiguous 4 | 8
Situs ambiguus 4 | 25
group 3 medulloblastoma 4 | 4,104
medulloblastoma, large-cell 4 | 6,241
osteosarcoma 4 | 7,950
Cancer 3 | 2,499
Congenital heart disease 3 | 93
Heterotaxy Syndrome 3 | 5
Holoprosencephaly 3 | 56
adult high grade glioma 3 | 3,801
atypical teratoid / rhabdoid tumor 3 | 5,112
glioblastoma 3 | 5,792
psoriasis 3 | 6,694
Alobar Holoprosencephaly 2 | 14
Astigmatism 2 | 54
Astrocytoma, Pilocytic 2 | 3,081
Cleft Palate 2 | 271
Lobar Holoprosencephaly 2 | 20
Multiple synostoses syndrome 2 | 9
Myopia 2 | 176
Semilobar Holoprosencephaly 2 | 14
Situs Inversus 2 | 65
Ventricular Septal Defects 2 | 119
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
interstitial cystitis 2 | 2,312
invasive ductal carcinoma 2 | 2,951
primitive neuroectodermal tumor 2 | 3,035
ATRIOVENTRICULAR CANAL DEFECT 1 | 17
Abnormalities, Multiple 1 | 13
Abnormality of the respiratory system 1 | 4
Appendicitis 1 | 15
Atrial Septal Defects 1 | 85
Autosomal recessive predisposition 1 | 1,442
Biliary atresia 1 | 12
Biliary atresia with splenic malformation syndrome 1 | 1
Breast cancer 1 | 3,578
Bronchiectasis 1 | 64
CONOTRUNCAL HEART MALFORMATIONS (disorder) 1 | 6
Cholecystitis 1 | 18
Cholelithiasis 1 | 33
Chromosome 18p deletion syndrome 1 | 5
Chromosome 9p deletion syndrome 1 | 13
Clubfoot 1 | 39
Conotruncal Heart Malformations 1 | 10
Cystic lymphangioma 1 | 19
Dextrocardia 1 | 12
DiGeorge syndrome 1 | 47
Discordant ventriculoarterial connection 1 | 17
Double Outlet Right Ventricle 1 | 11
Ectopic spleen 1 | 1
Endocardial Cushion Defects 1 | 17
Esophageal atresia 1 | 43
Fibrodysplasia ossificans progressiva 1 | 17
HETEROTAXY, VISCERAL, 4, AUTOSOMAL 1 | 1
Heterotaxy, Visceral, 2, Autosomal 1 | 2
Imperforate anus 1 | 25
Infertility 1 | 188
Intestinal Obstruction 1 | 31
Intrauterine retardation 1 | 176
Kartagener Syndrome 1 | 38
Kidney cancer 1 | 2,613
Liver cancer 1 | 604
Lung abscess 1 | 5
Microcephaly 1 | 166
Microphthalmia 1 | 76
Microsatellite Instability 1 | 12
Myopathy 1 | 185
Neurohypophyseal diabetes insipidus 1 | 13
Omphalocele 1 | 24
Parovarian cyst 1 | 1
Patau syndrome 1 | 14
Pick disease 1 | 1,894
Pre-Eclampsia 1 | 68
Primary ciliary dyskinesia 1 | 76
Right aortic arch (disorder) 1 | 1
Scoliosis 1 | 44
Septooptic dysplasia 1 | 19
Sinusitis 1 | 65
Transposition of Great Vessels 1 | 2
Velocardiofacial syndrome 1 | 46
active ulcerative colitis 1 | 764
acute myeloid leukemia 1 | 783
agnathia-otocephaly complex 1 | 8
ductal carcinoma in situ 1 | 1,745
fibroadenoma 1 | 559
lung cancer 1 | 4,740
lung carcinoma 1 | 2,843
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
posterior fossa group B ependymoma 1 | 416
spina bifida 1 | 1,074
subependymal giant cell astrocytoma 1 | 2,287
ulcerative colitis 1 | 1,819

Tissue

Digestive Tract 10 | 17,369
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678
Endocrine System 9 | 18,159
Nervous System 9 | 16,725
Blood and immune system 8 | 16,909
Respiratory system 8 | 16,393
Cardiovascular System 7 | 15,192

Target Family

Non-IDG 8 | 12,091
Kinase 3 | 634

Reactome Pathway

Regulation of signaling by NOD... 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Putative teratocarcinoma-derived growth factor 3 TDGF1P3 Tdark Non-IDG -1.99746 160.4 0
Cryptic protein CFC1 Tbio Non-IDG -1.89131 76.4 159
DAN domain family member 5 DAND5 Tbio Non-IDG -2.95138 850.2 112
Cerberus CER1 Tbio Non-IDG -2.32331 194.4 188
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303
Nodal homolog NODAL Tbio Non-IDG -3.00545 981.7 245
Activin receptor type-1C ACVR1C Tbio Kinase -1.53432 40.5 303
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG -1.99746 160.4 423
Left-right determination factor 1 LEFTY1 Tbio Non-IDG -1.83063 64.9 207