Development Level

Tbio 6 | 11,445
Tclin 6 | 613
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased circulating creatini... 2 | 39
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
decreased body weight 1 | 161
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
increased blood urea nitrogen ... 1 | 48
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
thrombocytopenia 1 | 56

Disease

Cancer 15 | 2,499
Carcinoma 15 | 11,493
ovarian cancer 14 | 8,520
osteosarcoma 12 | 7,950
medulloblastoma, large-cell 11 | 6,241
glioblastoma 9 | 5,792
juvenile dermatomyositis 9 | 1,187
psoriasis 9 | 6,694
invasive ductal carcinoma 8 | 2,951
lung cancer 7 | 4,740
Breast cancer 6 | 3,578
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Kidney cancer 5 | 2,613
Schizophrenia 5 | 1,160
Waldenstrons macroglobulinemia 5 | 765
atypical teratoid / rhabdoid tumor 5 | 5,112
group 4 medulloblastoma 5 | 1,855
pancreatic cancer 5 | 2,398
primary Sjogren syndrome 5 | 735
subependymal giant cell astrocytoma 5 | 2,287
Astrocytoma, Pilocytic 4 | 3,081
Blastic phase chronic myeloid leukemia 4 | 58
Chronic Myelocytic Leukemia Accelerated Phase 4 | 59
Cognitive delay 4 | 608
Frontal bossing 4 | 157
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
ependymoma 4 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
oligodendroglioma 4 | 2,850
primitive neuroectodermal tumor 4 | 3,035
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Diffuse large B-cell lymphoma 3 | 39
Joint laxity 3 | 54
Liver Cirrhosis, Experimental 3 | 769
Lymphoma, Large B-Cell, Diffuse 3 | 34
Melanoma 3 | 711
Orbital separation excessive 3 | 244
Pick disease 3 | 1,894
Rheumatoid arthritis 3 | 1,191
Ventricular Septal Defects 3 | 119
astrocytoma 3 | 1,146
ductal carcinoma in situ 3 | 1,745
follicular lymphoma 3 | 20
gastric carcinoma 3 | 807
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
nephrosclerosis 3 | 333
non-small cell lung cancer 3 | 2,890
pancreatic carcinoma 3 | 562
pediatric high grade glioma 3 | 1,064
Adenocarcinoma of lung 2 | 142
Alcoholic Intoxication, Chronic 2 | 289
Allergic hypersensitivity disease 2 | 126
Arthritis 2 | 290
Blepharoptosis 2 | 231
Congenital Epicanthus 2 | 177
Delayed speech and language development 2 | 112
Down syndrome 2 | 499
Endometrial cancer 2 | 311
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Kidney disease 2 | 430
Language Delay 2 | 112
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Liver cancer 2 | 604
Macrotia 2 | 87
Microstomia 2 | 78
Myopia 2 | 176
Pectus excavatum 2 | 100
Pediatric failure to thrive 2 | 365
Polymicrogyria 2 | 48
Seizures 2 | 596
Smooth philtrum 2 | 43
Speech Delay 2 | 112
Speech impairment 2 | 112
Stomach Neoplasms 2 | 300
Telecanthus 2 | 62
Triangular face 2 | 58
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
esophageal adenocarcinoma 2 | 737
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 17 | 16,909
Cardiovascular System 17 | 15,192
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678

Target Family

Kinase 9 | 634
Non-IDG 5 | 12,091
Enzyme 3 | 4,145

Reactome Pathway

Regulation of signaling by CBL 17 | 17
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Tyrosine-protein kinase HCK HCK Tclin Kinase -3.53517 3192.7 428
Proto-oncogene vav VAV1 Tchem Non-IDG -2.66356 489.1 548
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 Tbio Enzyme -1.57214 38.2 155
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform PIK3CB Tchem Kinase -2.29043 197.8 384
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA Tclin Kinase -3.04988 1076.8 484
Crk-like protein CRKL Tbio Non-IDG -2.20025 160.0 521