Development Level

Tbio 9 | 11,445
Tchem 5 | 1,598
Tclin 1 | 613

IMPC Phenotype

abnormal testis morphology 1 | 43
cataract 1 | 92
persistence of hyaloid vascula... 1 | 33
preweaning lethality, complete... 1 | 979
small testis 1 | 58

Disease

Carcinoma 12 | 11,493
osteosarcoma 10 | 7,950
ovarian cancer 10 | 8,520
medulloblastoma, large-cell 7 | 6,241
Acidosis, Lactic 5 | 97
Lactic acidosis 5 | 51
Leigh disease 5 | 100
glioblastoma 5 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
Autosomal recessive predisposition 4 | 1,442
Cognitive delay 4 | 608
Epilepsy 4 | 792
Global developmental delay 4 | 608
Lactic acidemia 4 | 95
Mental and motor retardation 4 | 608
Pyruvate decarboxylase deficiency 4 | 16
Seizures 4 | 596
acute quadriplegic myopathy 4 | 1,158
atypical teratoid / rhabdoid tumor 4 | 5,112
lung cancer 4 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
psoriasis 4 | 6,694
Decreased activity of the pyruvate dehydrogenase complex 3 | 3
Dull intelligence 3 | 645
Dystonia 3 | 164
Dystonic disease 3 | 106
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Pick disease 3 | 1,894
Poor school performance 3 | 645
Prostatic Neoplasms 3 | 495
Small head 3 | 374
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 4,104
juvenile dermatomyositis 3 | 1,187
ulcerative colitis 3 | 1,819
Abnormal ocular motility 2 | 19
Bipolar Disorder 2 | 666
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Cardiomyopathies 2 | 110
Cerebellar Ataxia 2 | 304
Highly variable severity 2 | 157
Hyper-beta-alaninemia 2 | 9
Increased blood alanine 2 | 9
Increased serum alanine 2 | 9
Infantile onset 2 | 238
Kaposi's Sarcoma Skin Lesions 2 | 8
Lethargy 2 | 77
Metabolic acidosis 2 | 90
Myocardial Ischemia 2 | 169
Obesity 2 | 678
Pyruvate Dehydrogenase Complex Deficiency Disease 2 | 2
Variable expressivity 2 | 157
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
astrocytoma 2 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
ependymoma 2 | 4,679
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
mucosa-associated lymphoid tissue lymphoma 2 | 484
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
pituitary cancer 2 | 1,972
Chemical and Drug Induced Liver Injury 1 | 195
Degenerative brain disorder 1 | 100
Degenerative polyarthritis 1 | 115
Dilated ventricles (finding) 1 | 121
Encephalopathies 1 | 43
Hypertrophic Cardiomyopathy 1 | 117
Impotence 1 | 42
Increased serum lactate 1 | 60
Increased serum pyruvate 1 | 9
Keratoconus 1 | 113
Low Birth Weights 1 | 69
Neonatal Hypotonia 1 | 64
Osteoarthritis 1 | 184
Osteoporosis 1 | 363
Prenatal onset 1 | 139
Small for gestational age (disorder) 1 | 69
Spastic Quadriplegia 1 | 42
Supratentorial atrophy 1 | 94
Systemic lupus erythematosus 1 | 194
head and neck cancer and chronic obstructive pulmonary disease 1 | 239
limb girdle muscular dystrophy 2B 1 | 40

Tissue

Endocrine System 15 | 18,159
Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Enzyme 9 | 4,145
Kinase 4 | 634
Nuclear Receptor 2 | 48

Reactome Pathway

Regulation of pyruvate dehydro... 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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