Development Level

Tbio 66 | 11,445
Tchem 10 | 1,598
Tclin 5 | 613
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 13 | 979
embryonic lethality prior to t... 6 | 278
abnormal embryo size 5 | 220
embryonic lethality prior to o... 5 | 239
embryonic growth retardation 4 | 106
increased mean corpuscular vol... 3 | 92
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal placenta size 2 | 20
anophthalmia 2 | 33
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal forebrain morphology 1 | 10
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal placenta morphology 1 | 5
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
brachydactyly 1 | 19
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating glucose ... 1 | 24
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
male infertility 1 | 123
microphthalmia 1 | 26
pallor 1 | 34
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
sclerocornea 1 | 2
small kidney 1 | 16
small spleen 1 | 19
small testis 1 | 58
syndactyly 1 | 23
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 62 | 8,520
psoriasis 43 | 6,694
lung cancer 42 | 4,740
Carcinoma 37 | 11,493
glioblastoma 37 | 5,792
osteosarcoma 37 | 7,950
Multiple myeloma 29 | 1,332
medulloblastoma, large-cell 29 | 6,241
Cancer 26 | 2,499
Breast cancer 25 | 3,578
atypical teratoid / rhabdoid tumor 24 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
non-small cell lung cancer 22 | 2,890
group 3 medulloblastoma 21 | 4,104
malignant mesothelioma 21 | 3,232
invasive ductal carcinoma 20 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
adult high grade glioma 18 | 3,801
adrenocortical carcinoma 17 | 1,428
lung adenocarcinoma 17 | 2,716
primitive neuroectodermal tumor 16 | 3,035
HIV Infections 15 | 102
ependymoma 15 | 4,679
colon cancer 14 | 1,478
pancreatic cancer 14 | 2,398
Endometriosis 13 | 540
Waldenstrons macroglobulinemia 13 | 765
Atopic dermatitis 12 | 952
breast carcinoma 12 | 1,638
dermatomyositis 12 | 966
ductal carcinoma in situ 11 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
primary Sjogren syndrome 11 | 735
oligodendroglioma 10 | 2,850
astrocytoma 9 | 1,146
nasopharyngeal carcinoma 9 | 1,058
Astrocytoma, Pilocytic 8 | 3,081
astrocytic glioma 8 | 2,597
esophageal adenocarcinoma 8 | 737
non primary Sjogren syndrome sicca 8 | 891
Pick disease 7 | 1,894
diabetes mellitus 7 | 1,728
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
ulcerative colitis 7 | 1,819
Liver Cirrhosis, Experimental 6 | 769
active Crohn's disease 6 | 922
medulloblastoma 6 | 720
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Intellectual disability 5 | 1,016
Kidney cancer 5 | 2,613
Mantle cell lymphoma 5 | 23
acute quadriplegic myopathy 5 | 1,158
cutaneous lupus erythematosus 5 | 1,057
lung carcinoma 5 | 2,843
Esophageal Squamous Cell Carcinoma 4 | 77
Osteoporosis 4 | 363
Squamous cell carcinoma of esophagus 4 | 77
acute myeloid leukemia 4 | 783
juvenile dermatomyositis 4 | 1,187
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
posterior fossa group A ependymoma 4 | 468
primary pancreatic ductal adenocarcinoma 4 | 1,109
Acquired metabolic disease 3 | 336
Anemia 3 | 365
Autosomal recessive predisposition 3 | 1,442
Cataract 3 | 297
Dull intelligence 3 | 645
Glaucoma 3 | 239
Hypoplastic mandible condyle 3 | 275
Lens Opacities 3 | 231
Low intelligence 3 | 645
Mammary Neoplasms, Experimental 3 | 154
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Neuronal ceroid lipofuscinosis 2 3 | 17
Polycystic ovary syndrome 3 | 360
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
group 4 medulloblastoma 3 | 1,855
posterior fossa group B ependymoma 3 | 416
progressive supranuclear palsy 3 | 676
Alzheimer's disease 2 | 658
Anteverted nostril 2 | 191
Carcinoma, Hepatocellular 2 | 228
Congenital Epicanthus 2 | 177
Duchenne muscular dystrophy 2 | 601
Leukemia 2 | 104
Liver carcinoma 2 | 240
Melanoma 2 | 711
Muscular dystrophy 2 | 75
Parkinson's disease 2 | 392
Stomach Neoplasms 2 | 300
cystic fibrosis 2 | 1,696
hepatocellular carcinoma 2 | 547
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Endocrine System 85 | 18,159
Blood and immune system 84 | 16,909
Digestive Tract 84 | 17,369
Female tissues 84 | 17,400
Male tissues 84 | 17,142
Nervous System 84 | 16,725
Respiratory system 84 | 16,393
Urinary Tract 84 | 16,678
Cardiovascular System 83 | 15,192
Liver and Pancreas 83 | 16,750
Skin and soft tissues 83 | 17,230

Target Family

Enzyme 51 | 4,145
Non-IDG 28 | 12,091
Kinase 7 | 634

Reactome Pathway

Regulation of mitotic cell cyc... 86 | 86
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Anaphase-promoting complex subunit 7 ANAPC7 Tbio Enzyme -0.17118 1.40 73
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Anaphase-promoting complex subunit 11 ANAPC11 Tbio Enzyme -1.27406 17.9 239