Development Level

Tbio 54 | 10,625
Tchem 25 | 1,890
Tclin 6 | 602
Tdark 2 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 3 | 148
abnormal retina morphology 2 | 100
embryonic lethality prior to t... 2 | 187
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal heart morphology 1 | 51
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal optic disc morphology 1 | 10
abnormal skin morphology 1 | 23
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating iron lev... 1 | 25
decreased leukocyte cell numbe... 1 | 54
decreased lymphocyte cell numb... 1 | 9
decreased neutrophil cell numb... 1 | 37
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
increased body length 1 | 20
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased heart rate 1 | 17
increased leukocyte cell numbe... 1 | 37
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
shortened RR interval 1 | 19

Disease

ovarian cancer 62 | 8,484
osteosarcoma 40 | 7,933
lung cancer 39 | 4,466
Multiple myeloma 36 | 1,327
glioblastoma 33 | 5,572
psoriasis 32 | 6,685
medulloblastoma, large-cell 24 | 6,234
Cancer 22 | 2,346
Waldenstrons macroglobulinemia 19 | 765
dermatomyositis 19 | 933
Breast cancer 17 | 3,094
atypical teratoid / rhabdoid tumor 17 | 4,369
HIV Infections 16 | 100
astrocytoma 16 | 1,493
group 3 medulloblastoma 15 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
oligodendroglioma 14 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
lung adenocarcinoma 13 | 2,713
ependymoma 12 | 2,514
invasive ductal carcinoma 12 | 2,950
malignant mesothelioma 12 | 3,162
pancreatic cancer 12 | 2,300
subependymal giant cell astrocytoma 12 | 2,287
lung carcinoma 11 | 2,844
non-small cell lung cancer 11 | 2,798
pediatric high grade glioma 11 | 2,712
pilocytic astrocytoma 11 | 3,086
astrocytic glioma 10 | 2,241
diabetes mellitus 10 | 1,663
juvenile dermatomyositis 10 | 1,189
primitive neuroectodermal tumor 10 | 3,031
group 4 medulloblastoma 9 | 1,875
Pick disease 8 | 1,893
acute myeloid leukemia 8 | 780
acute quadriplegic myopathy 8 | 1,157
colon cancer 8 | 1,475
ulcerative colitis 8 | 2,087
Carcinoma 7 | 2,147
breast carcinoma 7 | 1,614
posterior fossa group A ependymoma 7 | 1,511
primary Sjogren syndrome 7 | 789
Alzheimer's disease 6 | 644
Parkinson's disease 6 | 364
medulloblastoma 6 | 1,524
non primary Sjogren syndrome sicca 6 | 840
primary pancreatic ductal adenocarcinoma 6 | 1,271
progressive supranuclear palsy 6 | 674
Mantle cell lymphoma 5 | 18
Rheumatoid Arthritis 5 | 1,160
Vascular disease 5 | 281
cystic fibrosis 5 | 1,665
esophageal adenocarcinoma 5 | 737
spina bifida 5 | 1,064
Amyotrophic Lateral Sclerosis 4 | 431
Duchenne muscular dystrophy 4 | 602
IGA Glomerulonephritis 4 | 454
Neurodegenerative disease 4 | 383
Obesity 4 | 616
active Crohn's disease 4 | 918
adrenocortical carcinoma 4 | 1,427
aldosterone-producing adenoma 4 | 664
gastric carcinoma 4 | 832
hepatocellular carcinoma 4 | 532
pituitary cancer 4 | 1,972
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 3 months 4 | 327
tuberculosis and treatment for 6 months 4 | 686
Animal Mammary Neoplasms 3 | 136
Arthritis 3 | 248
Cardiomyopathies 3 | 90
Crohn's disease 3 | 304
Down syndrome 3 | 548
Hyperplasia 3 | 26
Liver neoplasms 3 | 109
Mammary Neoplasms, Experimental 3 | 150
Myocardial Ischemia 3 | 169
Osteoporosis 3 | 257
Squamous cell carcinoma 3 | 94
Stomach Neoplasms 3 | 282
adult high grade glioma 3 | 2,148
atypical teratoid/rhabdoid tumor 3 | 1,095
inflammatory breast cancer 3 | 404
interstitial cystitis 3 | 2,299
relapsing-remitting multiple sclerosis 3 | 18
tuberculosis 3 | 1,557
Contact Dermatitis 2 | 80
Heart disease 2 | 279
Leukemia 2 | 88
Lung disease 2 | 132
Multiple Sclerosis 2 | 498
Peripheral Neuropathy 2 | 303
Reperfusion Injury 2 | 84
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
fibroadenoma 2 | 557
limb girdle muscular dystrophy 2I 2 | 56
mucosa-associated lymphoid tissue lymphoma 2 | 480
pancreatic carcinoma 2 | 567

Tissue

Blood and immune system 87 | 17,995
Digestive Tract 87 | 18,473
Endocrine System 87 | 18,512
Female tissues 87 | 18,647
Liver and Pancreas 87 | 18,136
Male tissues 87 | 17,969
Nervous System 87 | 18,561
Urinary Tract 87 | 18,444
Cardiovascular System 86 | 17,958
Respiratory system 85 | 17,484
Skin and soft tissues 85 | 18,115

Target Family

Enzyme 50 | 4,146
Non-IDG 30 | 11,971
Kinase 6 | 634
GPCR 1 | 406

Reactome Pathway

Regulation of mRNA stability b... 87 | 87
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.89749 80.7 139
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
5'-3' exoribonuclease 1 XRN1 Tbio Enzyme -2.06818 114.2 45
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
mRNA decay activator protein ZFP36L1 ZFP36L1 Tbio Non-IDG -1.43974 36.3 260
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.80641 78.9 225
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.83653 71.4 158
26S protease regulatory subunit 8 PSMC5 Tbio Enzyme -1.68576 49.6 167