Development Level

Tbio 68 | 11,651
Tchem 11 | 1,388
Tclin 6 | 612
Tdark 3 | 6,593

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal vitreous body morphol... 1 | 10
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
increased body length 1 | 32
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased heart rate 1 | 23
increased heart weight 1 | 62
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
shortened RR interval 1 | 17

Disease

ovarian cancer 61 | 8,520
lung cancer 40 | 4,740
osteosarcoma 40 | 7,950
Carcinoma 38 | 11,493
Multiple myeloma 36 | 1,332
glioblastoma 33 | 5,792
psoriasis 32 | 6,694
group 3 medulloblastoma 24 | 4,104
medulloblastoma, large-cell 24 | 6,241
Cancer 22 | 2,499
Waldenstrons macroglobulinemia 19 | 765
dermatomyositis 19 | 966
atypical teratoid / rhabdoid tumor 18 | 5,112
ependymoma 18 | 4,679
Breast cancer 17 | 3,578
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
HIV Infections 16 | 102
oligodendroglioma 14 | 2,850
adult high grade glioma 13 | 3,801
astrocytic glioma 13 | 2,597
astrocytoma 13 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
lung adenocarcinoma 13 | 2,716
subependymal giant cell astrocytoma 13 | 2,287
invasive ductal carcinoma 12 | 2,951
malignant mesothelioma 12 | 3,232
non-small cell lung cancer 12 | 2,890
pancreatic cancer 12 | 2,398
lung carcinoma 11 | 2,843
Astrocytoma, Pilocytic 10 | 3,081
juvenile dermatomyositis 10 | 1,187
primitive neuroectodermal tumor 10 | 3,035
tuberculosis 10 | 2,010
diabetes mellitus 9 | 1,728
Pick disease 8 | 1,894
acute myeloid leukemia 8 | 783
acute quadriplegic myopathy 8 | 1,158
colon cancer 8 | 1,478
Liver Cirrhosis, Experimental 7 | 769
breast carcinoma 7 | 1,638
non primary Sjogren syndrome sicca 7 | 891
ulcerative colitis 7 | 1,819
Kidney cancer 6 | 2,613
primary Sjogren syndrome 6 | 735
progressive supranuclear palsy 6 | 676
Alzheimer's disease 5 | 658
Autosomal recessive predisposition 5 | 1,442
Mantle cell lymphoma 5 | 23
Parkinson's disease 5 | 392
Rheumatoid arthritis 5 | 1,191
cystic fibrosis 5 | 1,696
esophageal adenocarcinoma 5 | 737
group 4 medulloblastoma 5 | 1,855
medulloblastoma 5 | 720
spina bifida 5 | 1,074
Amyotrophic lateral sclerosis 4 | 451
Anemia 4 | 365
Duchenne muscular dystrophy 4 | 601
Neurodegenerative disease 4 | 414
Osteoporosis 4 | 363
Vascular disease 4 | 319
active Crohn's disease 4 | 922
adrenocortical carcinoma 4 | 1,428
aldosterone-producing adenoma 4 | 665
gastric carcinoma 4 | 807
hepatocellular carcinoma 4 | 547
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
Animal Mammary Neoplasms 3 | 136
Carcinoma, Squamous Cell 3 | 110
Cerebral atrophy 3 | 178
Cognitive delay 3 | 608
Crohn's disease 3 | 321
Down syndrome 3 | 499
Failure to gain weight 3 | 365
Global developmental delay 3 | 608
Liver neoplasms 3 | 130
Mammary Neoplasms, Animal 3 | 136
Mammary Neoplasms, Experimental 3 | 154
Mental and motor retardation 3 | 608
Myocardial Ischemia 3 | 169
Obesity 3 | 678
Pediatric failure to thrive 3 | 365
Schizophrenia 3 | 1,160
Stomach Neoplasms 3 | 300
inflammatory breast cancer 3 | 286
interstitial cystitis 3 | 2,312
relapsing-remitting multiple sclerosis 3 | 18
Dermatitis, Contact 2 | 71
Hepatomegaly 2 | 285
Hyperplasia 2 | 27
Leukemia 2 | 104
Multiple Sclerosis 2 | 540
Reperfusion Injury 2 | 86
Seizures 2 | 596
fibroadenoma 2 | 559
limb girdle muscular dystrophy 2I 2 | 32
pancreatic carcinoma 2 | 562

Tissue

Endocrine System 87 | 18,159
Blood and immune system 86 | 16,909
Digestive Tract 86 | 17,369
Female tissues 86 | 17,400
Male tissues 86 | 17,142
Nervous System 86 | 16,725
Respiratory system 86 | 16,393
Urinary Tract 86 | 16,678
Cardiovascular System 85 | 15,192
Liver and Pancreas 85 | 16,750
Skin and soft tissues 85 | 17,230

Target Family

Enzyme 50 | 4,145
Non-IDG 32 | 12,091
Kinase 5 | 634
GPCR 1 | 408

Reactome Pathway

Regulation of mRNA stability b... 88 | 88
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Poly(A)-specific ribonuclease PARN PARN Tbio Enzyme -1.87605 76.4 263
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tbio Enzyme -1.09295 11.9 110
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.22269 15.9 168
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689
MAP kinase-activated protein kinase 2 MAPKAPK2 Tchem Kinase -2.16502 140.7 702
Proteasome activator complex subunit 3 PSME3 Tbio Non-IDG -1.87037 83.7 245
ELAV-like protein 1 ELAVL1 Tchem Non-IDG -2.76074 585.8 338
Exosome complex component CSL4 EXOSC1 Tbio Non-IDG -2.07438 110.2 129