Development Level

Tbio 54 | 10,625
Tchem 24 | 1,890
Tclin 6 | 602
Tdark 2 | 7,003

Collection

GPCR: IDG Consortium (Targets) 1 | 128

IMPC Phenotype

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 3 | 148
abnormal retina morphology 2 | 100
embryonic lethality prior to t... 2 | 187
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat-hair pigmentatio... 1 | 54
abnormal heart morphology 1 | 51
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal optic disc morphology 1 | 10
abnormal skin morphology 1 | 23
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating iron lev... 1 | 25
decreased leukocyte cell numbe... 1 | 54
decreased lymphocyte cell numb... 1 | 9
decreased neutrophil cell numb... 1 | 37
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
increased body length 1 | 20
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased heart rate 1 | 17
increased leukocyte cell numbe... 1 | 37
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
shortened RR interval 1 | 19

Disease

ovarian cancer 61 | 8,491
osteosarcoma 40 | 7,933
lung cancer 39 | 4,473
Multiple myeloma 35 | 1,327
glioblastoma 33 | 5,572
psoriasis 32 | 6,685
medulloblastoma, large-cell 24 | 6,234
Cancer 22 | 2,346
Waldenstrons macroglobulinemia 18 | 764
dermatomyositis 18 | 966
atypical teratoid / rhabdoid tumor 17 | 4,369
Breast cancer 16 | 3,098
astrocytoma 16 | 1,493
HIV Infections 15 | 99
group 3 medulloblastoma 15 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
oligodendroglioma 14 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
lung adenocarcinoma 13 | 2,714
ependymoma 12 | 2,514
invasive ductal carcinoma 12 | 2,950
malignant mesothelioma 12 | 3,163
pancreatic cancer 12 | 2,300
subependymal giant cell astrocytoma 12 | 2,287
lung carcinoma 11 | 2,844
non-small cell lung cancer 11 | 2,798
pediatric high grade glioma 11 | 2,712
pilocytic astrocytoma 11 | 3,086
astrocytic glioma 10 | 2,241
diabetes mellitus 10 | 1,663
juvenile dermatomyositis 10 | 1,189
primitive neuroectodermal tumor 10 | 3,031
group 4 medulloblastoma 9 | 1,875
Pick disease 8 | 1,893
acute myeloid leukemia 8 | 785
acute quadriplegic myopathy 8 | 1,157
colon cancer 8 | 1,475
ulcerative colitis 8 | 2,087
Carcinoma 7 | 2,147
breast carcinoma 7 | 1,614
posterior fossa group A ependymoma 7 | 1,511
Alzheimer's disease 6 | 644
Parkinson's disease 6 | 364
medulloblastoma 6 | 1,524
non primary Sjogren syndrome sicca 6 | 840
primary Sjogren syndrome 6 | 788
primary pancreatic ductal adenocarcinoma 6 | 1,271
progressive supranuclear palsy 6 | 674
Mantle cell lymphoma 5 | 20
Vascular disease 5 | 281
cystic fibrosis 5 | 1,670
esophageal adenocarcinoma 5 | 737
spina bifida 5 | 1,064
Amyotrophic Lateral Sclerosis 4 | 432
Duchenne muscular dystrophy 4 | 602
IGA Glomerulonephritis 4 | 454
Neurodegenerative disease 4 | 383
Obesity 4 | 616
Rheumatoid Arthritis 4 | 1,170
active Crohn's disease 4 | 918
adrenocortical carcinoma 4 | 1,427
aldosterone-producing adenoma 4 | 664
gastric carcinoma 4 | 832
hepatocellular carcinoma 4 | 550
pituitary cancer 4 | 1,972
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 3 months 4 | 327
tuberculosis and treatment for 6 months 4 | 686
Arthritis 3 | 248
Cardiomyopathies 3 | 90
Crohn's disease 3 | 304
Down syndrome 3 | 548
Hyperplasia 3 | 26
Myocardial Ischemia 3 | 169
Osteoporosis 3 | 259
Squamous cell carcinoma 3 | 96
Stomach Neoplasms 3 | 282
adult high grade glioma 3 | 2,148
atypical teratoid/rhabdoid tumor 3 | 1,095
inflammatory breast cancer 3 | 404
interstitial cystitis 3 | 2,299
relapsing-remitting multiple sclerosis 3 | 18
tuberculosis 3 | 1,563
Bladder Neoplasm 2 | 109
Cholestasis 2 | 93
Contact Dermatitis 2 | 80
Heart disease 2 | 279
Leukemia 2 | 88
Lung disease 2 | 136
Multiple Sclerosis 2 | 498
Peripheral Neuropathy 2 | 303
Reperfusion Injury 2 | 84
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
fibroadenoma 2 | 557
limb girdle muscular dystrophy 2I 2 | 56
mucosa-associated lymphoid tissue lymphoma 2 | 480
non-small cell lung carcinoma 2 | 413
pancreatic carcinoma 2 | 567

Tissue

Blood and immune system 86 | 17,994
Digestive Tract 86 | 18,472
Endocrine System 86 | 18,511
Female tissues 86 | 18,646
Liver and Pancreas 86 | 18,135
Male tissues 86 | 17,968
Nervous System 86 | 18,560
Urinary Tract 86 | 18,443
Cardiovascular System 85 | 17,957
Respiratory system 84 | 17,483
Skin and soft tissues 84 | 18,114

Target Family

Enzyme 49 | 4,146
Non-IDG 30 | 11,969
Kinase 6 | 634
GPCR 1 | 408

Reactome Pathway

Regulation of mRNA stability b... 86 | 86
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.55872 362.3 648
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
Exosome complex component RRP4 EXOSC2 Tdark Non-IDG -0.28065 2.13 102
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 ENPP2 Tchem Enzyme -2.58707 432.7 278
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.95716 939.2 1717
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162
ELAV-like protein 1 ELAVL1 Tchem Non-IDG -2.72340 539.1 274
Protein kinase C alpha type PRKCA Tchem Kinase -2.39992 212.2 774
Poly(A)-specific ribonuclease PARN PARN Tbio Enzyme -1.84496 71.5 141
Mitogen-activated protein kinase 11 MAPK11 Tchem Kinase -2.03896 96.9 275