Development Level

Tbio 77 | 10,625
Tchem 31 | 1,890
Tclin 8 | 602
Tdark 6 | 7,003

IMPC Term

preweaning lethality, complete... 13 | 633
preweaning lethality, incomple... 5 | 260
abnormal embryo size 4 | 112
embryonic lethality prior to t... 4 | 187
increased or absent threshold ... 4 | 128
abnormal behavior 3 | 226
abnormal bone structure 3 | 131
decreased total body fat amoun... 3 | 186
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased Ly6C low monocyte nu... 2 | 23
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating alkaline... 2 | 41
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased leukocyte cell numbe... 2 | 54
decreased threshold for audito... 2 | 32
embryonic lethality prior to o... 2 | 148
hypoactivity 2 | 89
increased Ly6C high monocyte n... 2 | 12
increased body weight 2 | 42
abnormal coping response 1 | 12
abnormal craniofacial morpholo... 1 | 12
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal eye posterior chamber... 1 | 3
abnormal forebrain morphology 1 | 4
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal motor capabilities/co... 1 | 4
abnormal placenta size 1 | 10
abnormal respiratory quotient 1 | 9
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal tail bud morphology 1 | 6
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
absent heartbeat 1 | 6
absent optic nerve 1 | 1
anophthalmia 1 | 20
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased anxiety-related resp... 1 | 12
decreased cardiac output 1 | 2
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating amylase ... 1 | 24
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased hemoglobin content 1 | 53
decreased startle reflex 1 | 48
decreased vertical activity 1 | 22
embryonic growth retardation 1 | 28
enlarged heart 1 | 111
hemorrhage 1 | 12
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating phosphat... 1 | 24
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased rib number 1 | 41
increased total body fat amoun... 1 | 57
long tibia 1 | 13
microphthalmia 1 | 15
pale liver 1 | 5
pale yolk sac 1 | 12
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
shortened head 1 | 2
small testis 1 | 37
straub tail 1 | 26
thin ventricular wall 1 | 5

Disease

ovarian cancer 80 | 8,484
osteosarcoma 74 | 7,933
psoriasis 67 | 6,685
medulloblastoma, large-cell 52 | 6,234
glioblastoma 40 | 5,572
malignant mesothelioma 40 | 3,162
atypical teratoid / rhabdoid tumor 37 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,956
Cancer 34 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,289
lung cancer 33 | 4,466
Obesity 30 | 616
diabetes mellitus 30 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,988
Breast cancer 27 | 3,094
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
Pick disease 24 | 1,893
primitive neuroectodermal tumor 23 | 3,031
ulcerative colitis 23 | 2,087
pituitary cancer 22 | 1,972
subependymal giant cell astrocytoma 22 | 2,287
invasive ductal carcinoma 20 | 2,950
oligodendroglioma 20 | 2,849
Rheumatoid Arthritis 19 | 1,160
astrocytoma 19 | 1,493
interstitial cystitis 19 | 2,299
pediatric high grade glioma 19 | 2,712
Carcinoma 18 | 2,147
lung carcinoma 18 | 2,844
pancreatic cancer 18 | 2,300
tuberculosis 18 | 1,557
adrenocortical carcinoma 17 | 1,427
cystic fibrosis 17 | 1,665
ductal carcinoma in situ 17 | 1,745
ependymoma 17 | 2,514
group 3 medulloblastoma 17 | 2,254
acute quadriplegic myopathy 16 | 1,157
astrocytic glioma 16 | 2,241
Metabolic syndrome X 15 | 155
breast carcinoma 15 | 1,614
colon cancer 15 | 1,475
pilocytic astrocytoma 15 | 3,086
spina bifida 15 | 1,064
Mammary Neoplasms 14 | 410
group 4 medulloblastoma 14 | 1,875
Atherosclerosis 13 | 275
Lipid metabolism disorder 13 | 102
adult high grade glioma 13 | 2,148
juvenile dermatomyositis 13 | 1,189
lung adenocarcinoma 13 | 2,713
non-small cell lung cancer 13 | 2,798
primary pancreatic ductal adenocarcinoma 13 | 1,271
Fatty liver disease 12 | 84
Liver carcinoma 12 | 217
posterior fossa group B ependymoma 12 | 1,530
Endometriosis 11 | 535
Prostatic Neoplasms 11 | 471
aldosterone-producing adenoma 11 | 664
sonic hedgehog group medulloblastoma 11 | 1,482
Diabetes Mellitus, Experimental 10 | 106
active Crohn's disease 10 | 918
dermatomyositis 10 | 933
medulloblastoma 10 | 1,524
Coronary artery disease 9 | 240
Heart disease 9 | 279
Liver disease 9 | 219
Waldenstrons macroglobulinemia 9 | 765
gastric carcinoma 9 | 832
Amyotrophic Lateral Sclerosis 8 | 431
Atopic dermatitis 8 | 944
Drug-Induced Liver Injury 8 | 118
Hypertensive disease 8 | 193
IGA Glomerulonephritis 8 | 454
Multiple myeloma 8 | 1,327
acute myeloid leukemia 8 | 780
cutaneous lupus erythematosus 8 | 1,056
fibroadenoma 8 | 557
mucosa-associated lymphoid tissue lymphoma 8 | 480
tuberculosis and treatment for 6 months 8 | 686
Colorectal Neoplasms 7 | 217
Insulin Resistance 7 | 48
Intellectual disability 7 | 573
Kidney Failure, Chronic 7 | 45
Kidney disease 7 | 396
Stomach Neoplasms 7 | 282
active ulcerative colitis 7 | 477
atypical teratoid/rhabdoid tumor 7 | 1,095
non primary Sjogren syndrome sicca 7 | 840
pancreatic carcinoma 7 | 567
posterior fossa group A ependymoma 7 | 1,511
Bipolar Disorder 6 | 266
Hypertension 6 | 287
Inflammation 6 | 109
Peripheral Neuropathy 6 | 303
Polycystic Ovary Syndrome 6 | 332
nasopharyngeal carcinoma 6 | 1,056
Cerebrovascular disease 5 | 231
Myocardial Ischemia 5 | 169
esophageal adenocarcinoma 5 | 737
hepatocellular carcinoma 5 | 532

Tissue

Blood and immune system 122 | 17,995
Digestive Tract 122 | 18,473
Liver and Pancreas 122 | 18,136
Urinary Tract 122 | 18,444
Cardiovascular System 121 | 17,958
Endocrine System 121 | 18,512
Female tissues 121 | 18,647
Male tissues 121 | 17,969
Nervous System 121 | 18,561
Respiratory system 121 | 17,484
Skin and soft tissues 121 | 18,115

Target Family

Enzyme 46 | 4,146
Non-IDG 34 | 11,971
Transcription Factor 21 | 1,400
Epigenetic 7 | 242
Nuclear Receptor 7 | 48
Kinase 3 | 634
Transporter 3 | 473
TF/Epigenetic 1 | 38

Reactome Pathway

Regulation of lipid metabolism... 122 | 122
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Apolipoprotein A-II APOA2 Tbio Non-IDG -2.80284 593.9 352
Peroxisome proliferator-activated receptor gamma coactivator 1-beta PPARGC1B Tbio Non-IDG -2.61803 420.9 51
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.96870 90.3 172
Carnitine O-palmitoyltransferase 1, liver isoform CPT1A Tchem Enzyme -2.30451 203.2 252
Nuclear receptor ROR-alpha RORA Tchem Nuclear Receptor -2.17386 139.2 340
Paired amphipathic helix protein Sin3b SIN3B Tbio Non-IDG -1.25294 18.0 136
Peroxisomal membrane protein 11A PEX11A Tbio Non-IDG -1.69751 54.6 104
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM Tbio Enzyme -2.58670 387.0 269