Development Level

Tbio 15 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
impaired glucose tolerance 2 | 75
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal glucose homeostasis 1 | 4
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
thrombocytosis 1 | 27

Disease

diabetes mellitus 16 | 1,728
Carcinoma 14 | 11,493
Diabetes Mellitus, Non-Insulin-Dependent 11 | 145
Diabetes Mellitus, Type 2 11 | 142
Cancer 9 | 2,499
Hyperglycemia 9 | 137
Diabetes Mellitus, Experimental 8 | 108
maturity-onset diabetes of the young 8 | 32
medulloblastoma, large-cell 8 | 6,241
Diabetes Mellitus, Noninsulin-Dependent 7 | 31
Epilepsy 7 | 792
Seizures 7 | 596
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Autosomal recessive predisposition 6 | 1,442
Hyperinsulinism 6 | 133
Hypoglycemia 6 | 152
Maturity onset diabetes mellitus in young 6 | 11
Obesity 6 | 678
glioblastoma 6 | 5,792
group 3 medulloblastoma 6 | 4,104
Acquired metabolic disease 5 | 336
Breast cancer 5 | 3,578
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Global developmental delay 5 | 608
Glycosuria 5 | 29
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Poor school performance 5 | 645
ependymoma 5 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
pituitary cancer 5 | 1,972
Blepharoptosis 4 | 231
Failure to gain weight 4 | 365
Hyperinsulinemic hypoglycemia 4 | 17
Insulinoma 4 | 24
Liver Cirrhosis, Experimental 4 | 769
Pediatric failure to thrive 4 | 365
Type 2 diabetes mellitus 4 | 272
adult high grade glioma 4 | 3,801
malignant mesothelioma 4 | 3,232
psoriasis 4 | 6,694
Abnormality of the immune system 3 | 18
Adenoma 3 | 167
Anteverted nostril 3 | 191
Arthrogryposis 3 | 54
Astrocytoma, Pilocytic 3 | 3,081
Axial hypotonia 3 | 46
Bilateral ptosis 3 | 9
Congenital Heart Defects 3 | 58
Congenital heart disease 3 | 93
Curvature of digit 3 | 57
Dehydration 3 | 40
Diarrhea 3 | 253
Downturned corners of mouth 3 | 48
Epilepsies, Myoclonic 3 | 32
Generalized myoclonic seizures 3 | 30
Hepatomegaly 3 | 285
Hyperinsulinaemic hypoglycaemia 3 | 16
Hypovolemia 3 | 8
Hypsarrhythmia 3 | 25
Insulin Resistance 3 | 72
Intrauterine retardation 3 | 176
Ketoacidosis 3 | 11
Large for gestational age 3 | 11
Limb contractures 3 | 6
Lipid metabolism disorder 3 | 114
Long philtrum 3 | 137
Low Birth Weights 3 | 69
Motor delay 3 | 147
Muscle Weakness 3 | 170
Myoclonic Epilepsies, Progressive 3 | 44
Neonatal hypoglycemia 3 | 17
Neuropathy 3 | 261
No development of motor milestones 3 | 147
Peripheral Neuropathy 3 | 134
Polycystic ovary syndrome 3 | 360
Prominent metopic ridge 3 | 15
Prostatic Neoplasms 3 | 495
Radially deviated fingers 3 | 38
Retinal Diseases 3 | 55
Short nose 3 | 132
Small for gestational age (disorder) 3 | 69
Small nose 3 | 132
Tachycardia 3 | 43
Tonic - clonic seizures 3 | 44
Weight decreased 3 | 103
colon cancer 3 | 1,478
lung adenocarcinoma 3 | 2,716
lung cancer 3 | 4,740
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
permanent neonatal diabetes mellitus 3 | 9
ulcerative colitis 3 | 1,819

Tissue

Digestive Tract 20 | 17,369
Liver and Pancreas 20 | 16,750
Endocrine System 19 | 18,159
Skin and soft tissues 17 | 17,230
Female tissues 16 | 17,400
Urinary Tract 16 | 16,678
Nervous System 15 | 16,725
Male tissues 14 | 17,142
Blood and immune system 13 | 16,909
Respiratory system 10 | 16,393
Cardiovascular System 7 | 15,192

Target Family

Transcription Factor 11 | 1,400
Kinase 4 | 634
Non-IDG 2 | 12,091
Nuclear Receptor 2 | 48
Transporter 1 | 473

Reactome Pathway

Regulation of gene expression ... 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Paired box protein Pax-6 PAX6 Tbio Transcription Factor -3.16650 1458.6 570
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Transcription factor MafA MAFA Tbio Transcription Factor -1.36099 23.0 195
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.36445 252.7 605
DNA-binding protein RFX6 RFX6 Tbio Transcription Factor -2.57722 368.8 44
Hepatocyte nuclear factor 1-alpha HNF1A Tbio Transcription Factor -2.87439 680.9 0
Islet amyloid polypeptide IAPP Tbio Non-IDG -3.20630 1751.6 330
Homeobox protein Nkx-6.1 NKX6-1 Tbio Transcription Factor -1.86592 62.8 247
Hepatocyte nuclear factor 4-gamma HNF4G Tbio Nuclear Receptor -1.08671 9.11 135