Development Level

Tbio 155 | 11,445
Tdark 10 | 6,588
Tclin 5 | 613
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
prolonged QT interval 3 | 38
abnormal kidney morphology 2 | 65
decreased circulating total pr... 2 | 49
decreased total body fat amoun... 2 | 207
abnormal QT variability 1 | 10
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
decreased body length 1 | 101
decreased body weight 1 | 161
decreased cardiac stroke volum... 1 | 6
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased vertical activity 1 | 208
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
prolonged PR interval 1 | 15
prolonged QRS complex duration 1 | 8
prolonged ST segment 1 | 36
thrombocytosis 1 | 27

Disease

ovarian cancer 90 | 8,520
lung cancer 66 | 4,740
Multiple myeloma 51 | 1,332
Carcinoma 50 | 11,493
osteosarcoma 42 | 7,950
psoriasis 42 | 6,694
medulloblastoma, large-cell 37 | 6,241
diabetes mellitus 35 | 1,728
glioblastoma 33 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
Breast cancer 27 | 3,578
malignant mesothelioma 26 | 3,232
Diamond-Blackfan anemia 25 | 31
Waldenstrons macroglobulinemia 24 | 765
group 3 medulloblastoma 22 | 4,104
atypical teratoid / rhabdoid tumor 21 | 5,112
astrocytoma 19 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Cancer 18 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
acute quadriplegic myopathy 17 | 1,158
oligodendroglioma 17 | 2,850
Anemia 16 | 365
Cleft Palate 16 | 271
Uranostaphyloschisis 16 | 167
ependymoma 16 | 4,679
invasive ductal carcinoma 16 | 2,951
HIV Infections 15 | 102
non-small cell lung cancer 15 | 2,890
Fatigue 14 | 182
cystic fibrosis 14 | 1,696
dermatomyositis 14 | 966
Abnormality of the urinary system 13 | 21
Anemia, Diamond-Blackfan 13 | 16
Anemia, Macrocytic 13 | 18
Cardiac Arrhythmia 13 | 103
Cardiac conduction abnormalities 13 | 78
Conduction disorder of the heart 13 | 79
Delayed Puberty 13 | 97
EKG abnormalities 13 | 78
Electrocardiogram abnormal 13 | 81
Electrocardiogram change 13 | 78
Hand deformities 13 | 32
Intermittent migraine headaches 13 | 68
Kidney cancer 13 | 2,613
Migraine Disorders 13 | 76
Pallor 13 | 40
adult high grade glioma 13 | 3,801
genital abnormal 13 | 17
lung adenocarcinoma 13 | 2,716
reproductive system abnormality 13 | 17
acute myeloid leukemia 12 | 783
sonic hedgehog group medulloblastoma 12 | 467
Pick disease 11 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
subependymal giant cell astrocytoma 11 | 2,287
Astrocytoma, Pilocytic 9 | 3,081
Stomach Neoplasms 9 | 300
astrocytic glioma 9 | 2,597
breast carcinoma 9 | 1,638
lung carcinoma 9 | 2,843
Disease Progression 8 | 136
colon cancer 8 | 1,478
group 4 medulloblastoma 8 | 1,855
pancreatic cancer 8 | 2,398
pituitary cancer 8 | 1,972
primitive neuroectodermal tumor 8 | 3,035
Autosomal recessive predisposition 7 | 1,442
Breast Neoplasms 7 | 445
Intellectual disability 7 | 1,016
Mammary Neoplasms 7 | 425
juvenile dermatomyositis 7 | 1,187
mucosa-associated lymphoid tissue lymphoma 7 | 484
primary pancreatic ductal adenocarcinoma 7 | 1,109
Osteoporosis 6 | 363
active Crohn's disease 6 | 922
adrenocortical carcinoma 6 | 1,428
cutaneous lupus erythematosus 6 | 1,057
inflammatory breast cancer 6 | 286
interstitial cystitis 6 | 2,312
non primary Sjogren syndrome sicca 6 | 891
progressive supranuclear palsy 6 | 676
Adenocarcinoma of lung 5 | 142
Animal Mammary Neoplasms 5 | 136
Autistic Disorder 5 | 364
Cognitive delay 5 | 608
Disease Models, Animal 5 | 155
Duchenne muscular dystrophy 5 | 601
Global developmental delay 5 | 608
Hypoplastic mandible condyle 5 | 275
Infantile onset 5 | 238
Liver Cirrhosis, Experimental 5 | 769
Mammary Neoplasms, Experimental 5 | 154
Mandibular hypoplasia 5 | 275
Mental and motor retardation 5 | 608
Micrognathism 5 | 275
Short stature 5 | 531
primary Sjogren syndrome 5 | 735
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819

Tissue

Endocrine System 171 | 18,159
Blood and immune system 167 | 16,909
Digestive Tract 167 | 17,369
Female tissues 166 | 17,400
Male tissues 166 | 17,142
Nervous System 166 | 16,725
Respiratory system 166 | 16,393
Skin and soft tissues 166 | 17,230
Liver and Pancreas 165 | 16,750
Urinary Tract 164 | 16,678
Cardiovascular System 161 | 15,192

Target Family

Non-IDG 122 | 12,091
Enzyme 45 | 4,145
Transcription Factor 6 | 1,400

Reactome Pathway

Regulation of expression of SL... 173 | 173
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
60S ribosomal protein L36 RPL36 Tbio Non-IDG -1.62928 39.9 123
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Roundabout homolog 2 ROBO2 Tbio Non-IDG -1.89275 74.1 161
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A GSPT1 Tbio Enzyme -1.35573 22.8 99
60S ribosomal protein L35 RPL35 Tbio Non-IDG -1.30696 19.1 124