Development Level

Tbio 30 | 11,445
Tchem 22 | 1,598
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal embryo size 4 | 220
decreased total body fat amoun... 4 | 207
decreased circulating choleste... 3 | 93
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal forebrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating free fat... 2 | 31
decreased circulating glucose ... 2 | 126
decreased vertical activity 2 | 208
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
microphthalmia 2 | 26
preweaning lethality, incomple... 2 | 499
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain morphology 1 | 10
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
abnormal stomach morphology 1 | 10
anophthalmia 1 | 33
cataract 1 | 92
decreased body length 1 | 101
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased neutrophil cell numb... 1 | 42
enlarged heart 1 | 210
enlarged uterus 1 | 11
hemorrhage 1 | 23
hyperactivity 1 | 148
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small epididymis 1 | 3
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

ovarian cancer 44 | 8,520
Carcinoma 43 | 11,493
osteosarcoma 41 | 7,950
psoriasis 35 | 6,694
medulloblastoma, large-cell 31 | 6,241
glioblastoma 24 | 5,792
malignant mesothelioma 24 | 3,232
atypical teratoid / rhabdoid tumor 21 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Pick disease 18 | 1,894
Breast cancer 16 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
lung cancer 16 | 4,740
Cancer 15 | 2,499
invasive ductal carcinoma 15 | 2,951
group 3 medulloblastoma 14 | 4,104
adult high grade glioma 13 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Carcinoma, Hepatocellular 12 | 228
Kidney cancer 12 | 2,613
Liver carcinoma 12 | 240
Obesity 12 | 678
active Crohn's disease 12 | 922
ductal carcinoma in situ 12 | 1,745
interstitial cystitis 12 | 2,312
tuberculosis 12 | 2,010
acute quadriplegic myopathy 11 | 1,158
group 4 medulloblastoma 11 | 1,855
pituitary cancer 11 | 1,972
astrocytoma 10 | 1,146
oligodendroglioma 10 | 2,850
pancreatic cancer 10 | 2,398
astrocytic glioma 9 | 2,597
non-small cell lung cancer 9 | 2,890
subependymal giant cell astrocytoma 9 | 2,287
Intellectual disability 8 | 1,016
diabetes mellitus 8 | 1,728
ependymoma 8 | 4,679
primitive neuroectodermal tumor 8 | 3,035
Autosomal recessive predisposition 7 | 1,442
Fatty liver disease 7 | 103
Lipid metabolism disorder 7 | 114
Multiple myeloma 7 | 1,332
Short stature 7 | 531
active ulcerative colitis 7 | 764
aldosterone-producing adenoma 7 | 665
dermatomyositis 7 | 966
lung adenocarcinoma 7 | 2,716
non primary Sjogren syndrome sicca 7 | 891
Astrocytoma, Pilocytic 6 | 3,081
Atherosclerosis 6 | 291
Muscle hypotonia 6 | 571
Prostatic Neoplasms 6 | 495
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
Waldenstrons macroglobulinemia 6 | 765
breast carcinoma 6 | 1,638
cystic fibrosis 6 | 1,696
lung carcinoma 6 | 2,843
pediatric high grade glioma 6 | 1,064
Breast Neoplasms 5 | 445
Cataract 5 | 297
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Epilepsy 5 | 792
Failure to gain weight 5 | 365
Global developmental delay 5 | 608
Kidney Failure, Chronic 5 | 46
Low intelligence 5 | 645
Low set ears 5 | 181
Mammary Neoplasms 5 | 425
Mammary Neoplasms, Experimental 5 | 154
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Pediatric failure to thrive 5 | 365
Poor school performance 5 | 645
Seizures 5 | 596
Small head 5 | 374
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
gastric cancer 5 | 459
Acquired scoliosis 4 | 281
Broad flat nasal bridge 4 | 236
Congenital Epicanthus 4 | 177
Curvature of spine 4 | 282
Hepatomegaly 4 | 285
Hypoplastic mandible condyle 4 | 275
Intrauterine retardation 4 | 176
Lens Opacities 4 | 231
Long philtrum 4 | 137
Nasal bridge wide 4 | 236
atypical teratoid/rhabdoid tumor 4 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
chronic rhinosinusitis 4 | 512
colon cancer 4 | 1,478
hepatocellular carcinoma 4 | 547
spina bifida 4 | 1,074
ulcerative colitis 4 | 1,819

Tissue

Blood and immune system 58 | 16,909
Cardiovascular System 58 | 15,192
Digestive Tract 58 | 17,369
Endocrine System 58 | 18,159
Female tissues 58 | 17,400
Liver and Pancreas 58 | 16,750
Male tissues 58 | 17,142
Nervous System 58 | 16,725
Respiratory system 58 | 16,393
Skin and soft tissues 58 | 17,230
Urinary Tract 58 | 16,678

Target Family

Enzyme 25 | 4,145
Non-IDG 16 | 12,091
Transcription Factor 7 | 1,400
Nuclear Receptor 5 | 48
Epigenetic 4 | 242
Kinase 1 | 634

Reactome Pathway

Regulation of cholesterol bios... 58 | 58
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Insulin-induced gene 2 protein INSIG2 Tbio Non-IDG -1.94599 88.7 78
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177
Metal regulatory transcription factor 1 MTF1 Tbio Transcription Factor -1.98140 101.0 135
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.10571 12.4 88
Sterol regulatory element-binding protein cleavage-activating protein SCAP Tbio Non-IDG -1.85010 73.9 172
Sterol regulatory element-binding protein 2 SREBF2 Tchem Transcription Factor -2.61148 361.0 205
Helicase with zinc finger domain 2 HELZ2 Tdark Enzyme -0.50849 4.27 30