Development Level

Tbio 25 | 11,445
Tchem 7 | 1,598

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
decreased bone mineral density 2 | 126
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
fused cornea and lens 1 | 5
impaired pupillary reflex 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased total retina thickne... 1 | 4
iris synechia 1 | 3
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
thrombocytosis 1 | 27

Disease

Carcinoma 22 | 11,493
diabetes mellitus 20 | 1,728
Cancer 13 | 2,499
Diabetes Mellitus, Non-Insulin-Dependent 13 | 145
Diabetes Mellitus, Type 2 13 | 142
maturity-onset diabetes of the young 12 | 32
Hyperglycemia 11 | 137
medulloblastoma, large-cell 11 | 6,241
glioblastoma 9 | 5,792
lung cancer 9 | 4,740
ovarian cancer 9 | 8,520
Diabetes Mellitus, Experimental 8 | 108
Diabetes Mellitus, Noninsulin-Dependent 8 | 31
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
psoriasis 8 | 6,694
Autosomal recessive predisposition 7 | 1,442
Epilepsy 7 | 792
Failure to gain weight 7 | 365
Maturity onset diabetes mellitus in young 7 | 11
Pediatric failure to thrive 7 | 365
Seizures 7 | 596
osteosarcoma 7 | 7,950
Astrocytoma, Pilocytic 6 | 3,081
Breast cancer 6 | 3,578
Glycosuria 6 | 29
Hyperinsulinism 6 | 133
Hypoglycemia 6 | 152
Obesity 6 | 678
Type 2 diabetes mellitus 6 | 272
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
malignant mesothelioma 6 | 3,232
pituitary cancer 6 | 1,972
Acquired metabolic disease 5 | 336
Breast Neoplasms 5 | 445
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Global developmental delay 5 | 608
Insulin Resistance 5 | 72
Insulinoma 5 | 24
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mammary Neoplasms 5 | 425
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Poor school performance 5 | 645
Prostatic Neoplasms 5 | 495
adult high grade glioma 5 | 3,801
colon cancer 5 | 1,478
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
Alzheimer's disease 4 | 658
Blepharoptosis 4 | 231
Cataract 4 | 297
Dehydration 4 | 40
Diarrhea 4 | 253
Hyperinsulinemic hypoglycemia 4 | 17
Liver Cirrhosis, Experimental 4 | 769
Neuropathy 4 | 261
Pancreatic agenesis 4 | 17
atypical teratoid / rhabdoid tumor 4 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
ulcerative colitis 4 | 1,819
Abnormality of the immune system 3 | 18
Adenoma 3 | 167
Anteverted nostril 3 | 191
Elevated hepatic transaminases 3 | 81
Endometriosis 3 | 540
Hepatic enzyme increased 3 | 81
Hepatomegaly 3 | 285
Kidney disease 3 | 430
Lipid metabolism disorder 3 | 114
Liver Dysfunction 3 | 99
Liver enzymes abnormal 3 | 81
Liver function test increased 3 | 81
Liver function tests abnormal finding 3 | 81
Long philtrum 3 | 137
Melanoma 3 | 711
Motor delay 3 | 147
No development of motor milestones 3 | 147
Polycystic ovary syndrome 3 | 360
Prostate cancer 3 | 175
Short nose 3 | 132
Small nose 3 | 132
Strabismus 3 | 270
Subclinical abnormal liver function tests 3 | 81
Tachycardia 3 | 43
Transaminases increased 3 | 81
Vomiting 3 | 116
acute quadriplegic myopathy 3 | 1,158
cystic fibrosis 3 | 1,696
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
tuberculosis 3 | 2,010

Tissue

Digestive Tract 32 | 17,369
Endocrine System 30 | 18,159
Liver and Pancreas 30 | 16,750
Skin and soft tissues 27 | 17,230
Nervous System 26 | 16,725
Female tissues 25 | 17,400
Male tissues 24 | 17,142
Urinary Tract 24 | 16,678
Blood and immune system 22 | 16,909
Respiratory system 17 | 16,393
Cardiovascular System 13 | 15,192

Target Family

Transcription Factor 20 | 1,400
Kinase 4 | 634
Non-IDG 4 | 12,091
Nuclear Receptor 3 | 48
Transporter 1 | 473

Reactome Pathway

Regulation of beta-cell develo... 32 | 32
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Paired box protein Pax-6 PAX6 Tbio Transcription Factor -3.16650 1458.6 570
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Pancreas transcription factor 1 subunit alpha PTF1A Tbio Transcription Factor -2.60800 401.4 317
Transcription factor MafA MAFA Tbio Transcription Factor -1.36099 23.0 195
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.36445 252.7 605
DNA-binding protein RFX6 RFX6 Tbio Transcription Factor -2.57722 368.8 44
One cut domain family member 3 ONECUT3 Tbio Transcription Factor -1.90980 77.6 118
Hepatocyte nuclear factor 1-beta HNF1B Tbio Transcription Factor -2.63510 401.5 403
Hepatocyte nuclear factor 1-alpha HNF1A Tbio Transcription Factor -2.87439 680.9 0