Development Level

Tdark 71 | 6,593
Tbio 51 | 11,651
Tchem 12 | 1,388
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal coat-hair pigmentatio... 3 | 64
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal cornea morphology 2 | 31
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
embryonic lethality prior to t... 2 | 278
increased grip strength 2 | 41
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
small testis 2 | 58
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal iris pigmentation 1 | 4
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
absent urinary bladder 1 | 1
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged kidney 1 | 14
fused cornea and lens 1 | 5
fused phalanges 1 | 1
fusion of vertebral arches 1 | 7
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
male infertility 1 | 123
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
short tibia 1 | 97
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

osteosarcoma 50 | 7,950
Carcinoma 42 | 11,493
ovarian cancer 42 | 8,520
psoriasis 35 | 6,694
medulloblastoma, large-cell 27 | 6,241
Cancer 26 | 2,499
lung cancer 26 | 4,740
glioblastoma 25 | 5,792
interstitial cystitis 24 | 2,312
atypical teratoid / rhabdoid tumor 22 | 5,112
Breast cancer 20 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
tuberculosis 19 | 2,010
ependymoma 18 | 4,679
Multiple myeloma 17 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
lung carcinoma 17 | 2,843
non-small cell lung cancer 17 | 2,890
subependymal giant cell astrocytoma 17 | 2,287
ulcerative colitis 17 | 1,819
Astrocytoma, Pilocytic 16 | 3,081
lung adenocarcinoma 16 | 2,716
Kidney cancer 15 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
pancreatic cancer 15 | 2,398
adult high grade glioma 14 | 3,801
invasive ductal carcinoma 14 | 2,951
oligodendroglioma 14 | 2,850
Waldenstrons macroglobulinemia 12 | 765
Wiskott-Aldrich syndrome 12 | 30
astrocytic glioma 12 | 2,597
cutaneous lupus erythematosus 12 | 1,057
juvenile dermatomyositis 12 | 1,187
periodontitis 12 | 293
primary Sjogren syndrome 12 | 735
primitive neuroectodermal tumor 12 | 3,035
diabetes mellitus 11 | 1,728
Rheumatoid arthritis 10 | 1,191
Schizophrenia 10 | 1,160
group 3 medulloblastoma 10 | 4,104
malignant mesothelioma 10 | 3,232
primary pancreatic ductal adenocarcinoma 10 | 1,109
Pick disease 9 | 1,894
breast carcinoma 9 | 1,638
group 4 medulloblastoma 9 | 1,855
Autosomal recessive predisposition 8 | 1,442
Intellectual disability 8 | 1,016
Liver Cirrhosis, Experimental 8 | 769
chronic lymphosyte leukemia 8 | 204
cystic fibrosis 8 | 1,696
Immunologic Deficiency Syndromes 7 | 113
astrocytoma 7 | 1,146
colon cancer 7 | 1,478
mucosa-associated lymphoid tissue lymphoma 7 | 484
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pediatric high grade glioma 7 | 1,064
Kidney disease 6 | 430
Neoplasm Invasiveness 6 | 161
Thrombocytopenia 6 | 197
acute quadriplegic myopathy 6 | 1,158
cystic fibrosis and chronic rhinosinusitis 6 | 214
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
spina bifida 6 | 1,074
Amebiasis 5 | 21
Arthritis 5 | 290
Breast Neoplasms 5 | 445
Duchenne muscular dystrophy 5 | 601
Melanoma 5 | 711
Neoplasm Metastasis 5 | 168
gastric carcinoma 5 | 807
Alzheimer's disease 4 | 658
Attention deficit hyperactivity disorder 4 | 278
Bipolar Disorder 4 | 666
Chronic otitis media 4 | 52
Dull intelligence 4 | 645
Fatigue 4 | 182
Fever 4 | 138
Leukemia 4 | 104
Liver cancer 4 | 604
Low intelligence 4 | 645
Mammary Neoplasms 4 | 425
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple Sclerosis 4 | 540
Obesity 4 | 678
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Proteinuria 4 | 144
Recurrent respiratory infections 4 | 141
Sensorineural Hearing Loss (disorder) 4 | 284
Short stature 4 | 531
Vascular disease 4 | 319
acute myeloid leukemia 4 | 783
dermatomyositis 4 | 966
ear infection chronic 4 | 52
gastric cancer 4 | 459
medulloblastoma 4 | 720
pancreatic carcinoma 4 | 562
pituitary cancer 4 | 1,972

Tissue

Blood and immune system 60 | 16,909
Cardiovascular System 60 | 15,192
Digestive Tract 60 | 17,369
Endocrine System 60 | 18,159
Male tissues 60 | 17,142
Nervous System 60 | 16,725
Respiratory system 60 | 16,393
Skin and soft tissues 60 | 17,230
Urinary Tract 60 | 16,678
Female tissues 59 | 17,400
Liver and Pancreas 59 | 16,750

Target Family

Non-IDG 127 | 12,091
Kinase 8 | 634
Enzyme 2 | 4,145

Reactome Pathway

Regulation of actin dynamics f... 137 | 137
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
Protein BRICK1 BRK1 Tbio Non-IDG -1.43779 28.1 63
Unconventional myosin-Va MYO5A Tbio Non-IDG -1.77097 54.9 83
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452