Development Level

Tdark 58 | 7,003
Tbio 48 | 10,625
Tchem 14 | 1,890
Tclin 3 | 602

IMPC Phenotype

abnormal coat-hair pigmentatio... 3 | 54
decreased body weight 2 | 174
decreased circulating fructosa... 2 | 31
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal digit morphology 1 | 13
abnormal hair texture 1 | 4
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased Ly6C low monocyte nu... 1 | 23
decreased NK T cell number 1 | 28
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating creatini... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
fused cornea and lens 1 | 4
fused phalanges 1 | 1
fusion of vertebral arches 1 | 7
hyperactivity 1 | 108
impaired pupillary reflex 1 | 14
increased CD4-positive, alpha ... 1 | 15
increased Ly6C high monocyte n... 1 | 12
increased blood urea nitrogen ... 1 | 44
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased mean corpuscular vol... 1 | 91
increased red blood cell distr... 1 | 21
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
preweaning lethality, incomple... 1 | 260
vertebral fusion 1 | 23

Disease

osteosarcoma 48 | 7,933
ovarian cancer 42 | 8,491
psoriasis 33 | 6,685
medulloblastoma, large-cell 27 | 6,234
glioblastoma 25 | 5,572
lung cancer 25 | 4,473
Cancer 24 | 2,346
atypical teratoid / rhabdoid tumor 22 | 4,369
interstitial cystitis 22 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
Multiple myeloma 18 | 1,327
Breast cancer 17 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
lung carcinoma 17 | 2,844
subependymal giant cell astrocytoma 17 | 2,287
ulcerative colitis 17 | 2,087
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
pilocytic astrocytoma 16 | 3,086
tuberculosis 16 | 1,563
ependymoma 15 | 2,514
lung adenocarcinoma 15 | 2,714
non-small cell lung cancer 15 | 2,798
pancreatic cancer 15 | 2,300
invasive ductal carcinoma 14 | 2,950
oligodendroglioma 14 | 2,849
Carcinoma 13 | 2,147
Waldenstrons macroglobulinemia 13 | 764
juvenile dermatomyositis 13 | 1,189
pediatric high grade glioma 13 | 2,712
astrocytic glioma 12 | 2,241
cutaneous lupus erythematosus 12 | 1,056
primary Sjogren syndrome 12 | 788
primary pancreatic ductal adenocarcinoma 12 | 1,271
primitive neuroectodermal tumor 12 | 3,031
periodontitis 11 | 269
Rheumatoid Arthritis 10 | 1,170
Wiskott-Aldrich syndrome 10 | 27
diabetes mellitus 10 | 1,663
IGA Glomerulonephritis 9 | 454
Pick disease 9 | 1,893
malignant mesothelioma 9 | 3,163
medulloblastoma 9 | 1,524
adult high grade glioma 8 | 2,148
breast carcinoma 8 | 1,614
chronic lymphosyte leukemia 8 | 232
Amebiasis 7 | 22
astrocytoma 7 | 1,493
colon cancer 7 | 1,475
cystic fibrosis 7 | 1,670
group 4 medulloblastoma 7 | 1,875
sonic hedgehog group medulloblastoma 7 | 1,482
Leukemia 6 | 88
acute quadriplegic myopathy 6 | 1,157
cystic fibrosis and chronic rhinosinusitis 6 | 213
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
mucosa-associated lymphoid tissue lymphoma 6 | 480
spina bifida 6 | 1,064
Alzheimer's disease 5 | 644
Duchenne muscular dystrophy 5 | 602
Intellectual disability 5 | 573
Kidney disease 5 | 397
Lymphoma 5 | 57
Neoplasm Invasiveness 5 | 127
Neoplasm Metastasis 5 | 138
dermatomyositis 5 | 966
gastric carcinoma 5 | 832
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
tuberculosis and treatment for 6 months 5 | 686
Arthritis 4 | 248
Asthma 4 | 349
Mammary Neoplasms 4 | 410
Multiple Sclerosis 4 | 498
Parkinson's disease 4 | 364
Thrombocytopenia 4 | 105
Vascular disease 4 | 281
acute myeloid leukemia 4 | 785
gastric cancer 4 | 436
non primary Sjogren syndrome sicca 4 | 840
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567
pituitary cancer 4 | 1,972
posterior fossa group A ependymoma 4 | 1,511
Animal Mammary Neoplasms 3 | 135
Atopic dermatitis 3 | 944
Chronic obstructive pulmonary disease 3 | 147
Down syndrome 3 | 548
HIV Infections 3 | 99
Juvenile arthritis 3 | 124
Liver carcinoma 3 | 217
Lung Neoplasms 3 | 171
Major Depressive Disorder 3 | 106
Mammary Neoplasms, Experimental 3 | 149
Prostatic Neoplasms 3 | 471
Sensorineural hearing loss 3 | 107
Squamous cell carcinoma 3 | 96
adrenocortical carcinoma 3 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
group 3 medulloblastoma 3 | 2,254
inflammatory breast cancer 3 | 404

Tissue

Blood and immune system 108 | 17,994
Digestive Tract 108 | 18,472
Female tissues 108 | 18,646
Respiratory system 108 | 17,483
Liver and Pancreas 107 | 18,135
Skin and soft tissues 107 | 18,114
Urinary Tract 107 | 18,443
Cardiovascular System 105 | 17,957
Endocrine System 104 | 18,511
Nervous System 104 | 18,560
Male tissues 102 | 17,968

Target Family

Non-IDG 113 | 11,969
Kinase 8 | 634
Enzyme 2 | 4,146

Reactome Pathway

Regulation of actin dynamics f... 123 | 123
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
WAS/WASL-interacting protein family member 1 WIPF1 Tbio Non-IDG -2.00605 100.9 97
Proto-oncogene vav VAV1 Tchem Non-IDG -2.64007 465.9 479
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.78476 58.3 173
Ig lambda-6 chain C region IGLC6 Tdark Non-IDG -1.81183 228.7 0
Wiskott-Aldrich syndrome protein family member 2 WASF2 Tbio Non-IDG -2.86162 683.7 211
Abl interactor 2 ABI2 Tbio Non-IDG -1.35221 20.4 144
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
NCK-interacting protein with SH3 domain NCKIPSD Tbio Non-IDG -0.98081 14.9 92
Heat shock protein HSP 90-alpha HSP90AA1 Tchem Non-IDG -3.28941 4395.5 921
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.11789 1349.3 1026