Development Level

Tbio 22 | 11,445
Tchem 14 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
increased circulating LDL chol... 2 | 13
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal glucose homeostasis 1 | 4
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
embryonic lethality prior to t... 1 | 278
increased cardiac stroke volum... 1 | 1
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
thrombocytosis 1 | 27

Disease

Carcinoma 29 | 11,493
ovarian cancer 28 | 8,520
Cancer 24 | 2,499
osteosarcoma 24 | 7,950
glioblastoma 18 | 5,792
medulloblastoma, large-cell 18 | 6,241
lung cancer 16 | 4,740
psoriasis 16 | 6,694
Breast cancer 15 | 3,578
atypical teratoid / rhabdoid tumor 14 | 5,112
adult high grade glioma 13 | 3,801
group 3 medulloblastoma 12 | 4,104
malignant mesothelioma 12 | 3,232
adrenocortical carcinoma 11 | 1,428
pancreatic cancer 11 | 2,398
astrocytic glioma 9 | 2,597
ependymoma 9 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
primitive neuroectodermal tumor 9 | 3,035
ulcerative colitis 9 | 1,819
Astrocytoma, Pilocytic 8 | 3,081
Breast Neoplasms 8 | 445
Mammary Neoplasms 8 | 425
colon cancer 8 | 1,478
diabetes mellitus 8 | 1,728
Epilepsy 7 | 792
Melanoma 7 | 711
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
oligodendroglioma 7 | 2,850
subependymal giant cell astrocytoma 7 | 2,287
Carcinoma, Hepatocellular 6 | 228
Kidney cancer 6 | 2,613
Liver carcinoma 6 | 240
Pancreatic Neoplasm 6 | 85
Seizures 6 | 596
acute quadriplegic myopathy 6 | 1,158
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
lung adenocarcinoma 6 | 2,716
nasopharyngeal carcinoma 6 | 1,058
Amyotrophic lateral sclerosis 5 | 451
Immune system cancer 5 | 140
Intellectual disability 5 | 1,016
Li-Fraumeni syndrome 5 | 13
Lung Neoplasms 5 | 232
Lymphoid leukemia 5 | 160
Lymphoma 5 | 81
Multiple myeloma 5 | 1,332
Rheumatoid arthritis 5 | 1,191
Stomach Neoplasms 5 | 300
active Crohn's disease 5 | 922
acute myeloid leukemia 5 | 783
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
non-small cell lung cancer 5 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
Anemia 4 | 365
Atopic dermatitis 4 | 952
Autosomal recessive predisposition 4 | 1,442
Bladder Neoplasm 4 | 112
Chronic Lymphocytic Leukemia 4 | 262
Colonic Neoplasms 4 | 142
DOID:2627 4 | 94
Diffuse large B-cell lymphoma 4 | 39
Endometrial cancer 4 | 311
Endometriosis 4 | 540
Glaucoma 4 | 239
Liver cancer 4 | 604
Major Depressive Disorder 4 | 301
Pancreatic Neoplasms 4 | 85
Pick disease 4 | 1,894
Polycystic ovary syndrome 4 | 360
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Skin cancer 4 | 469
Stomach cancer 4 | 30
Unipolar Depression 4 | 250
Urinary Bladder Neoplasms 4 | 114
Vascular disease 4 | 319
Waldenstrons macroglobulinemia 4 | 765
interstitial cystitis 4 | 2,312
juvenile dermatomyositis 4 | 1,187
lung carcinoma 4 | 2,843
non-small cell lung carcinoma 4 | 317
progressive supranuclear palsy 4 | 676
tuberculosis and treatment for 6 months 4 | 409
Adenoma 3 | 167
Alzheimer's disease 3 | 658
Esophageal carcinoma 3 | 16
Hypertension 3 | 396
Kidney disease 3 | 430
Liver Cirrhosis, Experimental 3 | 769
Mouth Neoplasms 3 | 55
astrocytoma 3 | 1,146
cystic fibrosis 3 | 1,696
hepatocellular carcinoma 3 | 547
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074

Tissue

Blood and immune system 36 | 16,909
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678
Cardiovascular System 35 | 15,192

Target Family

Non-IDG 14 | 12,091
Enzyme 11 | 4,145
Kinase 9 | 634
Epigenetic 1 | 242
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

Reactome Pathway

Regulation of TP53 Expression ... 37 | 37
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Proline-rich protein 5 PRR5 Tbio Non-IDG -1.13287 3.70 143
Ubiquitin carboxyl-terminal hydrolase 2 USP2 Tbio Enzyme -1.91393 84.9 300
Serine/threonine-protein kinase Chk2 CHEK2 Tchem Kinase -3.00304 978.7 1374
Target of rapamycin complex 2 subunit MAPKAP1 MAPKAP1 Tbio Non-IDG -2.01676 101.3 244
Cyclin-A1 CCNA1 Tbio Non-IDG -2.02564 107.2 314